Identification and characterization of IL-10/IFN-γ–producing effector-like T cells with regulatory function in human blood

doi:10.1084/jem.20082238

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J Exp Med. 2009 May 11; 206(5): 1009–1017.

doi: 10.1084/jem.20082238

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Figure 2.

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Low expansion potential of IL-7R⁻ T cells in response to TCR stimulation and homeostatic cytokines. (A) Proliferative response of subsets purified according to CD25 and IL-7Rα expression in response to anti-CD3 antibodies in the absence or presence of exogenous IL-2 or co-stimulatory anti-CD28 antibodies. CFSE dilution of viable cells was assessed on day 4. One representative donor out of three is shown. (B) Proliferative response of subsets purified according to CCR7 and IL-7Rα expression in response to 25 ng/ml IL-7 or IL-15 on day 7. One representative donor out of four is shown. (C) The recovered number of cells after stimulation with IL-7, IL-15, or anti-CD3/28. Horizontal bars represent means. *, P < 0.05.

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