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Hemin utilization is related to virulence of Streptococcus pneumoniae.

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  • 1. Department of Microbiology, Howard University, Washington, D.C. 20059.
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    • Tai SS 1
    (1 author)

Infection and Immunity, 01 Dec 1993, 61(12):5401-5405
https://doi.org/10.1128/iai.61.12.5401-5405.1993 PMID: 8225615 PMCID: PMC281331

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Abstract 

Streptococcus pneumoniae is a causative agent for bacterial pneumonia, otitis media, meningitis, and bacteremia. Mechanisms for acquisition of iron by this organism under low-iron conditions were investigated. Siderophore production was not detected by either chemical or biological methods. Its utilization of iron-containing compounds found in human hosts was tested. Both hemin and hemoglobin supported the full growth of S. pneumoniae in a culture lacking other iron sources, while lactoferrin and transferrin failed to do so. A mutant defective in hemin utilization was isolated and was less virulent than wild-type S. pneumoniae in experimental animals.

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Infect Immun. 1993 Dec; 61(12): 5401–5405.
PMCID: PMC281331
PMID: 8225615

Hemin utilization is related to virulence of Streptococcus pneumoniae.

S S Tai, C J Lee, and R E Winter
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Abstract

Streptococcus pneumoniae is a causative agent for bacterial pneumonia, otitis media, meningitis, and bacteremia. Mechanisms for acquisition of iron by this organism under low-iron conditions were investigated. Siderophore production was not detected by either chemical or biological methods. Its utilization of iron-containing compounds found in human hosts was tested. Both hemin and hemoglobin supported the full growth of S. pneumoniae in a culture lacking other iron sources, while lactoferrin and transferrin failed to do so. A mutant defective in hemin utilization was isolated and was less virulent than wild-type S. pneumoniae in experimental animals.

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Selected References

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