| PMC full text: | Alcohol Clin Exp Res. Author manuscript; available in PMC 2012 Apr 1. Published in final edited form as: Alcohol Clin Exp Res. 2011 Apr; 35(4): 735–746. Published online 2011 Jan 11. doi: 10.1111/j.1530-0277.2010.01391.x |
Table 1
Function and Biology of genes with their DNA methylation altered by alcohol during differentiation in adult rat DRG stem cells validated by Sequenom.
| Gene Symbol | Description | Methylation altered by Alcohol | Function | Biology |
|---|---|---|---|---|
| Cutl2 (Cux2) | cut-like 2 (Drosophila) (predicted) | Down | Transcription factor | Regulates cell cycle progression in neural progenitor cells during spinal cord neurogenesis, dorsal interneuron formation. |
| Igf1 | insulin-like growth factor 1 | Down | Growth factor | Mediates neuron like differentiation of adipose derived stem cells, progenitor cell proliferation, inhibits cell death and promotes recovery of differentiated neurons. |
| Tnf | tumor necrosis factor (TNF superfamily, member 2) | Down | Cytokine | Mediates downregulation of GLT1 and neuronal death in brainstem and cervical motor neurons, proinflammation in adult neural stem/progenitor cells |
| Pou4f3 | POU domain, class 4, transcription factor 3 (predicted) | Down | Transcription factor | Retinal neuron specification, differentiation and survival, autoregulation of inner ear and CNS sensory neurons. |
| Lim2 | lens intrinsic membrane protein 2 | Down | Receptor | Lens development |
| Sox7 | SRY-box containing gene 7 (predicted) | Down | Transcription factor | Activator of FGF-3 transcription in embryonal stem cells |
| Smarca2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | Up | Chromatin remodeling complex | Essential for differentiation, cell growth control, cell growth inhibitory activity cyclin D3 through C/EBP alpha and Brm complex |
| Efemp1 | epidermal growth factor-containing fibulin-like extracellular matrix protein 1 | Down | Extracellular matrix protein with EGF domain | Tumor growth |
| Hal | histidine ammonia lyase | Down | Cytosolic enzyme | Histidine catabolism |
| Dgcr2 | DiGeorge syndrome critical region gene 2 | Up | Adhesion receptor protein | Developmental deficits |
| Pard6a | par-6 (partitioning defective 6,) homolog alpha (C. elegans) | Up | Asymmetrical cell division and cell polarization | Migration of immature granule neurons, neuroblast cell polarity |