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FIGURE 9.

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IFNαβR knockout affects LPS-stimulated IL-6 but not TNF-α or IL-12 production. Wild-type or IL-10 knockout BMDMs were pretreated with 0.5 μM Ruxolitinib where indicated and then stimulated with 100 ng/ml LPS for the indicated times. Levels of TNF-α (A), IL-12p70 (B), IL-12p40 (C), and IL-6 (D) secreted into the media were determined by Luminex-based multiplex assay (left panels). Levels of TNF-α (A), IL-12p35 (B), IL-12p40 (C), and IL-6 (D) mRNA were determined by Q-PCR (right panels). Error bars represent the SD of independent BMDM cultures from four mice per genotype.

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