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Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence.

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Proceedings of the National Academy of Sciences of the United States of America, 01 Dec 1980, 77(12):7024-7028
https://doi.org/10.1073/pnas.77.12.7024 PMID: 6938951 PMCID: PMC350433

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Abstract 

A single-point mutation, consisting of a T-to-G transversion, was made in the third nucleotide of the conalbumin gene T-A-T-A-A-A-A homology sequence (the T-A-T-A or Goldberg-Hogness box). In an in vitro system, specific transcription of the mutant DNA was drastically decreased compared to the normal gene. This down-mutation is consistent with the idea that the T-A-T-A box is an important element for specific initiation of transcription.

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Proc Natl Acad Sci U S A. 1980 Dec; 77(12): 7024–7028.
PMCID: PMC350433
PMID: 6938951

Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence.

B Wasylyk, R Derbyshire, A Guy, D Molko, A Roget, R Téoule, and P Chambon
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Abstract

A single-point mutation, consisting of a T-to-G transversion, was made in the third nucleotide of the conalbumin gene T-A-T-A-A-A-A homology sequence (the T-A-T-A or Goldberg-Hogness box). In an in vitro system, specific transcription of the mutant DNA was drastically decreased compared to the normal gene. This down-mutation is consistent with the idea that the T-A-T-A box is an important element for specific initiation of transcription.

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Selected References

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