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Mutant of Bordetella pertussis which lacks ability to produce filamentous hemagglutinin.

Infection and Immunity, 01 Mar 1982, 35(3):1018-1023
https://doi.org/10.1128/iai.35.3.1018-1023.1982 PMID: 6279510 PMCID: PMC351149

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Abstract 

Mutant cultures that lacked the ability to produce filamentous hemagglutinin were obtained by UV irradiation of Bordetella pertussis strain 18-323. Various biological activities of these mutants were compared with those of the parent culture. It was found that the leukocytosis-promoting, histamine-sensitizing, and mouse-protecting activities of the mutants were similar to those of the parent strain but that the virulence to mice was lower. The results seemed to rule out fimbrial hemagglutinin as a protective antigen when the ability to protect mice was measured by the intracerebral challenge test.

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Infect Immun. 1982 Mar; 35(3): 1018–1023.
PMCID: PMC351149
PMID: 6279510

Mutant of Bordetella pertussis which lacks ability to produce filamentous hemagglutinin.

M Watanabe and Y Nakase
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Abstract

Mutant cultures that lacked the ability to produce filamentous hemagglutinin were obtained by UV irradiation of Bordetella pertussis strain 18-323. Various biological activities of these mutants were compared with those of the parent culture. It was found that the leukocytosis-promoting, histamine-sensitizing, and mouse-protecting activities of the mutants were similar to those of the parent strain but that the virulence to mice was lower. The results seemed to rule out fimbrial hemagglutinin as a protective antigen when the ability to protect mice was measured by the intracerebral challenge test.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Arai H, Sato Y. Separation and characterization of two distinct hemagglutinins contained in purified leukocytosis-promoting factor from Bordetella pertussis. Biochim Biophys Acta. 1976 Oct 22;444(3):765–782. [Abstract] [Google Scholar]
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