Figure 8

Fibrosis in the heart, diaphragm and abdominal muscles is modified by a locus on chromosome 2. Genome-wide association was examined for fibrosis in Sgcg^MRL/D2 progeny in the (A) cardiac muscle (n = 65), (B) diaphragm (n = 78) and (C) abdominal muscle (n = 78). Chromosomes are plotted on the x axis, and the informative SNPs tested (n = 1,707) are displayed as open circles that alternate color by chromosome; LOD scores are represented on the y axis. Overlapping regions on chromosome 2 showed suggestive (p < 0.63) association with fibrosis in heart, diaphragm and abdominal muscle.