Figure 5

The inward rectifier K⁺ current (I _K1) recorded from the ventricular cells of control and H/M-Sod2 ^−/− mice and influences of chronic AP intake. (a) Representative traces of I _K1 recorded from the left ventricular cells of each group. (b) Densities of I _K1 of the left ventricular cells of each group. The density of I _K1 was measured at the end of a hyperpolarizing pulse to –50mV from a holding potential of –40mV. Note that the density of I _K1 in H/M-Sod2 ^−/− ventricular cells was significantly smaller than that in control cells and that the reduction in I _K1 density in H/M-Sod2 ^−/− cells was improved by chronic AP intake. Values are mean ± SEM, control, n = 32; control + AP, n = 31; H/M-Sod2 ^−/−, n = 32; and H/M-Sod2 ^−/− + AP, n = 32. Differences between groups, *P < 0.05.