Abstract
Free full text
A mutant of Saccharomyces cerevisiae defective for nuclear fusion.
Abstract
A mutant unable to fuse nuclei during mating has been isolated from standard wild-type Saccharomyces cerevisiae. Tetrad analysis of the mutation responsible for this defect (kar1-1) shows that it segregates as a single Mendelian factor. The defect kn kaf1-1 appears to be nuclear limited. Cytological and genetic evidence shows that in this mutant the events associated with zygote formation are normal until the point of nuclear fusion. The consequence of this defect is the formation of a multinucleate zygote which in subsequent divisions can segregate heterokaryons and haploid heterplasmons.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.2M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Wright RE, Lederberg J. EXTRANUCLEAR TRANSMISSION IN YEAST HETEROKARYONS. Proc Natl Acad Sci U S A. 1957 Oct 15;43(10):919–923. [Europe PMC free article] [Abstract] [Google Scholar]
- Aigle M, Lacroute F. Genetical aspects of [URE3], a non-mitochondrial, cytoplasmically inherited mutation in yeast. Mol Gen Genet. 1975;136(4):327–335. [Abstract] [Google Scholar]
- Hartwell LH, Culotti J, Reid B. Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A. 1970 Jun;66(2):352–359. [Europe PMC free article] [Abstract] [Google Scholar]
- Slater ML. Rapid nuclear staining method for Saccharomyces cerevisiae. J Bacteriol. 1976 Jun;126(3):1339–1341. [Europe PMC free article] [Abstract] [Google Scholar]
- Hartwell LH. Synchronization of haploid yeast cell cycles, a prelude to conjugation. Exp Cell Res. 1973 Jan;76(1):111–117. [Abstract] [Google Scholar]
- Byers B, Goetsch L. Behavior of spindles and spindle plaques in the cell cycle and conjugation of Saccharomyces cerevisiae. J Bacteriol. 1975 Oct;124(1):511–523. [Europe PMC free article] [Abstract] [Google Scholar]
- Fink GR, Styles CA. Curing of a killer factor in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1972 Oct;69(10):2846–2849. [Europe PMC free article] [Abstract] [Google Scholar]
- Burton EG, Metzenberg RL. Novel mutation causing derepression of several enzymes of sulfur metabolism in Neurospora crassa. J Bacteriol. 1972 Jan;109(1):140–151. [Europe PMC free article] [Abstract] [Google Scholar]
Associated Data
Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences
Full text links
Read article at publisher's site: https://doi.org/10.1073/pnas.73.10.3651
Read article for free, from open access legal sources, via Unpaywall:
https://europepmc.org/articles/pmc431176?pdf=render
Citations & impact
Impact metrics
Citations of article over time
Alternative metrics
Discover the attention surrounding your research
https://www.altmetric.com/details/134502138
Article citations
The middle domain of Hsp104 can ensure substrates are functional after processing.
PLoS Genet, 20(10):e1011424, 03 Oct 2024
Cited by: 0 articles | PMID: 39361717 | PMCID: PMC11478891
Methodological advances enabled by the construction of a synthetic yeast genome.
Cell Rep Methods, 4(4):100761, 01 Apr 2024
Cited by: 1 article | PMID: 38653205 | PMCID: PMC11046031
Frequent horizontal chromosome transfer between asexual fungal insect pathogens.
Proc Natl Acad Sci U S A, 121(11):e2316284121, 05 Mar 2024
Cited by: 1 article | PMID: 38442176 | PMCID: PMC10945790
Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast <i>synIX</i> strains.
Cell Genom, 3(11):100419, 09 Nov 2023
Cited by: 4 articles | PMID: 38020974 | PMCID: PMC10667316
Detection of Primary DNA Lesions by Transient Changes in Mating Behavior in Yeast Saccharomyces cerevisiae Using the Alpha-Test.
Int J Mol Sci, 24(15):12163, 29 Jul 2023
Cited by: 1 article | PMID: 37569542 | PMCID: PMC10418631
Go to all (318) article citations
Data
Similar Articles
To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.
Bud selection and apoptosis-like degradation of nuclei in yeast heterokaryons: a KAR1 effect.
Mol Genet Genomics, 274(4):419-427, 14 Sep 2005
Cited by: 2 articles | PMID: 16160851
Nuclear fusion-defective phenocopies in Chlamydomonas reinhardtii: mating-type functions for meiosis can act through the cytoplasm.
Proc Natl Acad Sci U S A, 85(11):3946-3950, 01 Jun 1988
Cited by: 6 articles | PMID: 3375248 | PMCID: PMC280337
Physiology of mating in three yeasts.
Adv Microb Physiol, 15:307-398, 01 Jan 1977
Cited by: 22 articles | PMID: 333877
Nuclear fusion in the yeast Saccharomyces cerevisiae.
Annu Rev Cell Dev Biol, 12:663-695, 01 Jan 1996
Cited by: 69 articles | PMID: 8970740
Review
