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Do cells cycle?

Proceedings of the National Academy of Sciences of the United States of America, 01 Apr 1973, 70(4):1263-1267
https://doi.org/10.1073/pnas.70.4.1263 PMID: 4515625 PMCID: PMC433472

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Abstract 

We propose that a cell's life is divided into two fundamentally different parts. Some time after mitosis all cells enter a state (A) in which their activity is not directed towards replication. A cell may remain in the A-state for any lenght of time, throughout which its probability of leaving A-state remains constant. On leaving A-state, cells enter B-phase in which their activities are deterministic, and directed towards replication. Initiation of cell replication processes is thus random, in the sense that radioactive decay is random. Cell population growth rates are determined by the probability with which cells leave the A-state, the duration of the B-phase, and the rate of cell death. Knowledge of these parameters permits precise calculation of the distribution of intermitotic times within populations, the behavior of synchronized cell cultures, and the shape of labeled mitosis curves.

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Proc Natl Acad Sci U S A. 1973 Apr; 70(4): 1263–1267.
PMCID: PMC433472
PMID: 4515625

Do Cells Cycle?

J. A. Smith and L. Martin
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Abstract

We propose that a cell's life is divided into two fundamentally different parts. Some time after mitosis all cells enter a state (A) in which their activity is not directed towards replication. A cell may remain in the A-state for any lenght of time, throughout which its probability of leaving A-state remains constant. On leaving A-state, cells enter B-phase in which their activities are deterministic, and directed towards replication. Initiation of cell replication processes is thus random, in the sense that radioactive decay is random. Cell population growth rates are determined by the probability with which cells leave the A-state, the duration of the B-phase, and the rate of cell death. Knowledge of these parameters permits precise calculation of the distribution of intermitotic times within populations, the behavior of synchronized cell cultures, and the shape of labeled mitosis curves.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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