HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development

doi:10.1038/srep21884

PMC full text:

Sci Rep. 2016; 6: 21884.

Published online 2016 Feb 22. doi: 10.1038/srep21884

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This article has been retracted. Retraction in: Sci Rep. 2022 April 8; 12: 5931 See also: PMC Retraction Policy

Figure 3

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HMGB1 Facilitated Macrophage Reprogramming towards M1-like dependent on PI3Kγ- Erk1/2 pathway.

(A,B) HMGB1 activated the PI3Kγ/Erk1/2 in ANA-1. ANA-1 was treated by 100ng/ml rHMGB1. At the points indicated, cells was harvested; phosphorylated PI3Kγ and Erk1/2 levels were assessed by western blot. Representative blots were shown above and densitometric analyses below. (C) iNOS and Arg-1 mRNA expression in HMGB1-treated ANA-1 macrophages with/without AS605240 or U0126 pre-exposure for 1h. Values were expressed as iNOS and Arg-1 compared with 18s. Data were means±SD from three independent experiments. p-values were calculated using the paired t-test. p<0.05 was considered statistically significant.

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