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Platelet inhibition with Ticlopidine in atherosclerotic intermittent claudication.

Journal of Clinical Pathology, 01 Jul 1982, 35(7):740-743
https://doi.org/10.1136/jcp.35.7.740 PMID: 7047575 PMCID: PMC497768

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Abstract 

Fifty-one men with atherosclerotic intermittent claudication and haemorheological abnormalities completed a double-blind, one-year randomised trial of Ticlopidine (500 mg/day), a new antiplatelet agent. Ticlopidine caused significant inhibition of platelet aggregation but did not fully correct abnormalities of coagulation, viscosity, and fibrinolysis. There was no significant improvement in walking ability, Doppler ankle-pressure indices, or calf blood flow. Sustained platelet inhibition for 12 months was insufficient to correct the prothrombotic abnormality of extensive atherosclerosis.

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J Clin Pathol. 1982 Jul; 35(7): 740–743.
PMCID: PMC497768
PMID: 7047575

Platelet inhibition with Ticlopidine in atherosclerotic intermittent claudication.

A Aukland, R A Hurlow, A J George, and J Stuart
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Abstract

Fifty-one men with atherosclerotic intermittent claudication and haemorheological abnormalities completed a double-blind, one-year randomised trial of Ticlopidine (500 mg/day), a new antiplatelet agent. Ticlopidine caused significant inhibition of platelet aggregation but did not fully correct abnormalities of coagulation, viscosity, and fibrinolysis. There was no significant improvement in walking ability, Doppler ankle-pressure indices, or calf blood flow. Sustained platelet inhibition for 12 months was insufficient to correct the prothrombotic abnormality of extensive atherosclerosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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