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Table 2.

qtphase scan of the eight markers associated with an increase in autoantibody titers, conditioning on DR3
Haplotypes†
HLA-DR 82-3 TNFd TNFb C1-2-C MIB HLA-B8 C1-4-4 C2-4-5 Frequencies Mean of log10 titers Individual P Overall P
1 1 1 1 0.49 1.378 0.10 0.0028
1 2 2 2 0.08 2.051 0.0016
2 2 2 2 0.24 1.482 0.81
1 1 1 1 0.52 1.247 0.0035 0.00080
1 2 2 2 0.07 1.984 0.0013
2 2 2 2 0.27 1.448 0.62
1 1 1 1 0.49 1.317 0.023 0.00035
1 2 2 2 0.08 2.168 0.00010
2 2 2 2 0.26 1.433 0.79
1 1 1 1 0.49 1.354 0.13 0.0000088
1 2 2 2 0.09 2.221 0.0000047
2 2 2 2 0.28 1.429 0.96
1 1 1 1 0.53 1.394 0.094 0.000020
1 2 2 2 0.08 2.357 0.000018
2 2 2 2 0.27 1.461 0.81
1 1 1 1 0.29 1.242 0.016 0.000063
1 2 2 2 0.09 2.218 0.000050
2 2 2 2 0.26 1.451 0.92
1 1 1 1 1 1 1 1 1 0.20 1.210 0.036 0.00042
1 2 2 2 2 2 2 2 2 0.06 2.443 0.000094
2 2 2 2 2 2 2 2 2 0.22 1.416 0.75
†Alleles were recoded; 1 refers to the absence and 2 to the presence of the 8.1-associated allele at the marker considered. The three most characteristic haplotypes are displayed