Figure 3

Analysis of p53 polymorphisms in patients with ACC. Genotypes were determined by using four markers, including two intragenic p53 polymorphisms. Their positions relative to the p53 gene and their order on chromosome 17 are shown next to an ideogram of chromosome 17. Allelic order of the boxed markers was determined by studies of at least one parent or sibling. Because the markers clearly differed even among patients for whom the allelic order could not be confirmed, a founder effect is highly unlikely to account for the presence of the mutation. D17S1832 and D17S786 = dinucleotide repeat markers; p53(AAAAT)_n = intragenic p53 pentanucleotide polymorphism located in intron 1; p53(CA)_n = intragenic p53 dinucleotide polymorphism located in codon 213.