Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression

PMC full text:

Published online 2018 Jul 3. doi: 10.1186/s13045-018-0632-2

Copyright/LicenseRequest permission to reuse: Copyright © The Author(s). 2018
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Table 3

Univariate and multivariate Cox regression analyses of clinicopathological features association with prognosis of 53 CRC patients (cohort 1)

Variables	Subset	Univariate analysis		Multivariate analysis
Variables	Subset	HR (95% CI)	P value	HR (95% CI)	P value
Age (years)	<60 vs. ≥60	1.379(0.525–2.484)	0.495	–	–
Gender	Male vs. female	1.514(0.701–2.916)	0.410	–	–
Tumor size	<5 cm vs. ≥5 cm	2.438(1.003–5.105)	0.062	–	–
Tumor location	Colon vs. rectum	1.028(0.712–1.582)	0.875	–	–
Histologic grade	Well/moderately vs. poorly/others	1.847(0.571–2.896)	0.289	–	–
Depth of invasion	T1,T2 vs. T3,T4	2.561(0.911–4.616)	0.124	–	–
Lymphatic metastasis	Absent vs. Present	3.054(1.008–5.531)	0.028*	2.313(0.869–4.012)	0.045*
Venous invasion	Absent vs. Present	1.478(0.491–3.292)	0.353	–	–
Distant metastasis	Absent vs. Present	3.681(1.308–5.928)	0.004*	3.163(1.586–5.275)	0.011*
Tumor stage	I-II vs. III-IV	4.422(1.849–8.241)	<0.001*	3.549(1.301–6.684)	0.002*
SNHG7 expression	Low vs. high	3.317(1.331–5.609)	0.008*	2.924(1.035–5.268)	0.030*

HR hazard ratio, CI confidence interval

*P<0.05