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Table 1

Participant characteristics from five European birth cohorts.

CharacteristicBAMSEGINIplusLISAplusMASPIAMA
CountrySwedenGermanyGermanyGermanyThe Netherlands
Years of recruitment1994–19961995–19981997–199919901996–1997
Number of children at recruitment4,0895,9913,0941,3143,963
Number of children included in final study population, n (%)3,112 (76.1)2,956 (49.3)1,456 (47.1)560 (42.6)2,519 (63.6)
Number of children with complete information on all selected covariatesa, n (%)2,928 (71.6)2,254 (37.6)733 (23.7)427 (32.5)2,423 (61.1)
Maternal smoking during pregnancy, n (%)     
 Yes379 (12.2)352 (12.0)183 (13.0)106 (20.1)362 (14.5)
 No2,732 (87.8)2,589 (88.0)1,229 (87.0)421 (79.9)2,140 (85.5)
 Missing (n)115443317
SHS during infancy, n (%)     
 Yes631 (20.4)289 (17.2)215 (15.6)224 (42.9)536 (21.4)
 No2,463 (79.6)1,396 (82.8)1,161 (84.4)298 (57.1)1974 (78.6)
 Missing (n)181,27180389
Male sex, n (%)     
 Male1,530 (49.2)1,468 (49.7)744 (51.1)292 (52.1)1,267 (50.3)
 Female1,582 (50.8)1,488 (50.3)712 (48.9)268 (47.9)1,252 (49.7)
 Missing (n)00000
Mean birth weight (g), mean ± SD3,530±5613,466±4643,483±4483,398±4623,531±532
 Missing (n)2996038
Mean gestation age (wk), mean ± SD39.8 ± 2.039.8 ± 1.539.9 ± 1.240.0 ± 1.539.9 ± 1.6
 Missing (n)036624135
Parental education, n (%)
 Low514 (16.5)231 (8.2)49 (3.4)38 (7.5)263 (10.5)
 Medium884 (28.4)793 (28.1)352 (24.4)174 (34.7)866 (34.5)
 High1,710 (55.1)1,802 (63.7)1,044 (72.2)290 (57.8)1,384 (55.0)
 Missing (n)413011586
Parental allergyb, n (%)     
 Yes944 (30.6)1,303 (46.2)713 (52.3)270 (50.3)1,064 (42.7)
 No2,138 (69.4)1,520 (53.8)651 (47.7)267 (49.7)1,427 (57.3)
 Missing (n)30133922328
Older siblings, n (%)     
 Yes1,472 (47.3)1469 (50.3)652 (44.8)219 (39.1)1234 (49.0)
 No1640 (52.7)1450 (49.7)803 (55.2)341 (60.9)1285 (51.0)
 Missing (n)037100
Breastfeeding, n (%)     
  ≥ 4 mo2442 (80.3)2031 (70.9)1138 (82.7)338 (60.4)990 (39.6)
  < 4 mo600 (19.7)835 (29.1)238 (17.3)222 (39.6)1508 (60.4)
 Missing (n)709080021
Early mold or dampness in dwelling (0–2 y), n (%)     
 Yes785 (25.3)447 (26.1)559 (39.0)74 (14.2)1049 (45.8)
 No2319 (74.7)1264 (73.9)875 (61.0)444 (85.8)1242 (54.2)
 Missing (n)8172242228
Early day care (0–2 y), n (%)     
 Yes2548 (84.3)126 (4.7)384 (44.6)145 (29.0)1,472 (59.2)
 No476 (15.7)2,586 (95.3)478 (55.4)355 (71.0)1,013 (40.8)
 Missing (n)882445946034

Note: Based on children with information about smoke exposure during pregnancy or infancy and at least one health outcome at 14–16 y of age. BAMSE, Children, Allergy, Milieu, Stockholm, Epidemiology; GINIplus, German Infant Nutritional Intervention; LISAplus, Influences of Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood; MAS, Multicentre Allergy Study; PIAMA, Prevention and Incidence of Asthma and Mite Allergy; SD, standard deviation; SHS, secondhand smoke.

aParticipants in the final study population with complete information on the following covariates: maternal smoking during pregnancy, SHS exposure during infancy, sex, birth weight, gestational age, parental education, parental allergy, older siblings, breastfeeding, early mold or dampness in dwelling, and early day-care attendance.
bMother and/or father with asthma and/or hay fever.