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Interleukin-1 is an astroglial growth factor in the developing brain.

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  • 1. Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
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    • Giulian D 1
    (1 author)

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 01 Feb 1988, 8(2):709-714
https://doi.org/10.1523/jneurosci.08-02-00709.1988 PMID: 3257519 PMCID: PMC6569312

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Abstract 

The immunomodulator interleukin-1 (IL-1) is found to be an astroglial growth factor during development of the mammalian brain. In vitro studies indicate that ameboid microglia, a class of brain mononuclear phagocytes, are the likely source of IL-1. Examination of different brain regions during development shows IL-1 production only after the appearance of ameboid microglia. These observations suggest that brain mononuclear phagocytes secrete growth factors that regulate normal growth and development of the CNS.

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Logo of jneurosciThis ArticleAbout the JournalFor AuthorsSign up for AlertsThe Journal of NeuroscienceSociety for Neuroscience
J Neurosci. 1988 Feb 1; 8(2): 709–714.
PMCID: PMC6569312
PMID: 3257519

Interleukin-1 is an astroglial growth factor in the developing brain

D Giulian, DG Young, J Woodward, DC Brown, and LB Lachman
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Abstract

The immunomodulator interleukin-1 (IL-1) is found to be an astroglial growth factor during development of the mammalian brain. In vitro studies indicate that ameboid microglia, a class of brain mononuclear phagocytes, are the likely source of IL-1. Examination of different brain regions during development shows IL-1 production only after the appearance of ameboid microglia. These observations suggest that brain mononuclear phagocytes secrete growth factors that regulate normal growth and development of the CNS.

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Funding 

Funders who supported this work.

NEI NIH HHS (1)

NINDS NIH HHS (2)