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Relationship of carotid intima-media thickness, pulse wave velocity, and ankle brachial index to the severity of coronary artery atherosclerosis.

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Affiliations

  • 1. Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan.
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    • Matsushima Y 1
    (1 author)

ORCIDs linked to this article

Clinical Cardiology, 01 Nov 2004, 27(11):629-634
https://doi.org/10.1002/clc.4960271110 PMID: 15562933 PMCID: PMC6654351

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Abstract 

Background

Carotid intima-media thickness (IMT), pulse wave velocity (PWV), and the ankle brachial index (ABI) are widely used noninvasive modalities for evaluating atherosclerosis.

Hypothesis

The aim of this study was to determine the relationship of carotid IMT, PWV, and ABI with the severity of coronary artery disease (CAD), expressed as the Gensini score, and the presence of coronary risk factors.

Methods

We examined 205 consecutive patients (mean age 65 +/- 12 years) who were clinically suspected of having CAD and were scheduled to undergo coronary angiography. Carotid intima-media thickness, brachial-ankle PWV (baPWV), and ABI were measured in all subjects before they underwent coronary angiography.

Results

Of the 205 patients, 124 patients were diagnosed as having CAD based on the presence of >50% stenosis in a major coronary artery; the remaining 81 patients did not have CAD. A relatively good correlation was obtained between carotid IMT and the Gensini score (R = 0.411, p < 0.0001), whereas baPWV correlated only weakly with the Gensini score (R = 0.203, p = 0.0035), and ABI did not correlate with it. A multiple regression analysis revealed that the Gensini score correlated significantly and independently with age, male gender, and carotid IMT.

Conclusions

Of the three noninvasive methods, carotid IMT may be more useful for determining coronary artery atherosclerosis than baPWV or ABI.

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Logo of clincardiolLink to Publisher's site
Clin Cardiol. 2004 Nov; 27(11): 629–634.
Published online 2006 Dec 5. https://doi.org/10.1002/clc.4960271110
PMCID: PMC6654351
PMID: 15562933

Relationship of carotid intima‐media thickness, pulse wave velocity, and ankle brachial index to the severity of coronary artery atherosclerosis

Yoshihiro Matsushima, M.D.,corresponding author 1 Hiroaki Kawano, M.D., 1 Yuji Koide, M.D., 1 Takeshi Baba, M.D., 1 Genji Toda, M.D., 1 Shinji Seto, M.D., 1 and Katsusuke Yano, M.D. 1
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Abstract

Background: Carotid intima‐media thickness (IMT), pulse wave velocity (PWV), and the ankle brachial index (ABI) are widely used noninvasive modalities for evaluating atherosclerosis.

Hypothesis: The aim of this study was to determine the relationship of carotid IMT, PWV, and ABI with the severity of coronary artery disease (CAD), expressed as the Gensini score, and the presence of coronary risk factors.

Methods: We examined 205 consecutive patients (mean age 65 ± 12 years) who were clinically suspected of having CAD and were scheduled to undergo coronary angiography. Carotid intima‐media thickness, brachial‐ankle PWV (baPWV), and ABI were measured in all subjects before they underwent coronary angiography.

Results: Of the 205 patients, 124 patients were diagnosed as having CAD based on the presence of > 50% stenosis in a major coronary artery; the remaining 81 patients did not have CAD. A relatively good correlation was obtained between carotid IMT and the Gensini score (R = 0.411, p < 0.0001), whereas baPWV correlated only weakly with the Gensini score (R = 0.203, p = 0.0035), and ABI did not correlate with it. A multiple regression analysis revealed that the Gensini score correlated significantly and independently with age, male gender, and carotid IMT.

Conclusions: Of the three noninvasive methods, carotid IMT may be more useful for determining coronary artery atherosclerosis than baPWV or ABI.

Keywords: atherosclerosis, intima‐media thickness, pulse wave velocity, ankle‐brachial index, coronary artery disease

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Selected References

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