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The involvement of endothelial progenitor cells in tumor angiogenesis.

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  • 1. Department of Human Anatomy and Histology, University of Bari Medical School, Bari I-70124, Italy.
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    • Ribatti D 1
    (1 author)

Journal of Cellular and Molecular Medicine, 01 Jul 2004, 8(3):294-300
https://doi.org/10.1111/j.1582-4934.2004.tb00319.x PMID: 15491505 PMCID: PMC6740146

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Abstract 

Endothelial progenitor cells (EPCs) have been isolated from peripheral blood CD34, VEGFR-2, or AC 133 (CD133) antigen-positive cells, which may home to site of neovascularization and differentiate into endothelial cells in situ. Endothelial cells contribute to tumor angiogenesis, and can originate from sprouting or co-option of neighbouring pre-existing vessels. Emerging evidence indicate that bone marrow-derived circulating EPCs can contribute to tumor angiogenesis and growth of certain tumors. This review article will summarize the literature data concerning this new role played by EPCs in tumor angiogenesis.

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J Cell Mol Med. 2004 Jul; 8(3): 294–300.
PMCID: PMC6740146
PMID: 15491505

The involvement of endothelial progenitor cells in tumor angiogenesis

Domenico Ribatti 1
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Abstract

Endothelial progenitor cells (EPCs) have been isolated from peripheral blood CD34, VEGFR‐2, or AC 133 (CD133) antigen‐positive cells, which may home to site of neovascularization and differentiate into endothelial cells in situ. Endothelial cells contribute to tumor angiogenesis, and can originate from sprouting or co‐option of neighbouring pre‐existing vessels. Emerging evidence indicate that bone marrow‐derived circulating EPCs can contribute to tumor angiogenesis and growth of certain tumors. This review article will summarize the literature data concerning this new role played by EPCs in tumor angiogenesis.

Keywords: angiogenesis, endothelial progenitor cells, tumor

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