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PMC full text:
Nature. Author manuscript; available in PMC 2019 Oct 16.
Published in final edited form as:
Nature. 2015 Feb 26; 518(7540): 556–559.
Published online 2014 Dec 15. doi: 10.1038/nature13994

Figure 1

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Distinct sets of enhancers activate transcription from the hkCP and dCP in S2 cells.

a, STARR-seq setup using the hkCP housekeeping (RpS12; purple) and dCP developmental core promoter (DSCP11; brown) b, Genome browser screenshot depicting STARR-seq tracks for both core promoters. c, Overlap of hkCP and dCP enhancers. d, hkCP versus dCP STARR-seq enrichments at enhancers (insets show replicates for hkCP and dCP; dCP data from ref. 12). e, hkCP, dCP, or shared enhancers that activate luciferase (>1.5-fold & P<0.05 [one-sided t-test]; n=3; Extended Data Figs 3 and ​and5)5) from hkCP (purple) or dCP (brown; numbers: positive/tested).

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