Heparan sulfate proteoglycans and their modification as promising anticancer targets in hepatocellular carcinoma

PMC full text:

Published online 2021 Jan 4. doi: 10.3892/ol.2021.12434

Copyright/LicenseRequest permission to reuse: Copyright : © Alshehri et al.
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Table III.

Summary of studies that assessed sulfatase-2 inhibitors in the treatment of HCC.

Model	Summary	Cell type	(Refs.)
Human	2,4-Disulfonylphenyl-tert-butylnitrone (OKN-007) produces antitumor effects against HCC by suppressing TGF-β1/SMAD2 and Hedgehog/GLI1 signaling	Huh7	(36)
Rats	Adiponectin inhibits sulfatase-2 activity, leading to hepatoprotective and chemoprotective effects	Liver cells	(35)
	Sodium ascorbate produces cytotoxic effects against HCC, which can be explained by the inhibition of sulfatase-2	Liver cells	(81)
Mice	Silencing sulfatase-2 signaling inhibits angiogenesis and tumor growth by inhibiting TGF-β1/SMAD	Liver cells	(82)

HCC, hepatocellular carcinoma.