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Table 2

Transcriptomic and Proteomic Integrative Analysis.

Canonical PathwayRNA-SeqProteomicsScoreCategory
EIF2 Signaling 0.509 5.84 6.349 Growth
Regulation of eIF4 and p70S6K Signaling 0.209 5.53 5.739 Growth
tRNA Charging 1.57 3.87 5.44 Growth
CD28 Signaling in T Helper Cells 1.17 3.47 4.64 Immune
Integrin Signaling 0.527 3.64 4.167 Migration
fMLP Signaling in Neutrophils 0.471 3.56 4.031 Immune
Actin Nucleation by ARP-WASP Complex 0.62 3.4 4.02 Migration
Role of PKR in Interferon Induction and Antiviral Response 1.51 2.31 3.82 Immune
IL-17A Signaling in Fibroblasts 3.57 0.198 3.768 Immune
IL-6 Signaling 2.24 1.37 3.61 Immune
Regulation of IL-2 Expr in Activated and Anergic T Lymphocytes 2.66 0.732 3.392 Immune
Actin Cytoskeleton Signaling 0.756 2.58 3.336 Immune
RhoGDI Signaling 0.26 3.01 3.27 Migration
Acute Phase Response Signaling 1.18 2.03 3.21 Immune
Ephrin Receptor Signaling 0.209 3 3.209 Migration
Superpathway of Cholesterol Biosynthesis 2.94 0.198 3.138 Growth
Dendritic Cell Maturation 0.209 2.86 3.069 Immune
JAK/Stat Signaling 1.3 1.72 3.02 Growth
PI3K Signaling in B Lymphocytes 2.81 0.198 3.008 Immune
Rac Signaling 0.514 2.49 3.004 Migration
PKCθ Signaling in T Lymphocytes 1.64 1.35 2.99 Immune
mTOR Signaling 0.209 2.76 2.969 Growth
PPAR Signaling 2.28 0.665 2.945 Growth
CD27 Signaling in Lymphocytes 2.73 0.198 2.928 Immune
4-1BB Signaling in T Lymphocytes 2.72 0.198 2.918 Immune
Protein Ubiquitination Pathway 0.549 2.33 2.879 Growth
EGF Signaling 0.979 1.88 2.859 Growth
VEGF Signaling 0.209 2.65 2.859 Growth
Signaling by Rho Family GTPases 0.403 2.44 2.843 Growth
PDGF Signaling 1.19 1.65 2.84 Growth
Selenocysteine Biosynthesis II (Archaea and Eukaryotes) 1.02 1.82 2.84 Growth
Oncostatin M Signaling 0.36 2.47 2.83 Immune
Cdc42 Signaling 0.603 2.16 2.763 Migration
Fatty Acid β-oxidation I 0.209 2.52 2.729 Growth
Estrogen-Dependent Breast Cancer Signaling 0.861 1.78 2.641 Growth
Role of NFAT in Regulation of the Immune Response 0.71 1.93 2.64 Immune
IL-17 Signaling 1.86 0.708 2.568 Immune
Th1 Pathway 0.209 2.32 2.529 Immune

Signaling pathways associated with growth, immune, and migration are highlighted in orange, green, and blue colors, respectively.