mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations

doi:10.1016/j.vaccine.2022.08.024

PMC full text:

Vaccine. 2022 Oct 6; 40(42): 6114–6124.

Published online 2022 Sep 15. doi: 10.1016/j.vaccine.2022.08.024

Copyright/LicenseRequest permission to reuse: Copyright © 2022 Published by Elsevier Ltd.
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

Table 2

Geometric means of AUC and AUC fold change for each ELISA antigen.

		Geometric mean AUCs		Geometric mean AUC fold change
	Timepoint/ vaccine	BNT162b2 G.M. AUC	mRNA-1273 G.M. AUC	BNT162b2 (G.M.F.I)	mRNA-1273 (G.M.F.I)
Spike	Prime	1569.32	2043.64	313.86	408.73
Spike	Boost	7405.92	7974.32	1481.18	1594.86
BNT162b2 LNP	Prime	0.54	1.54	0.92	2.25
BNT162b2 LNP	Boost	0.58	7.04	1.07	4.28
mRNA-1273 LNP	Prime	0.55	1.84	1.1	2.6
mRNA-1273 LNP	Boost	0.66	8.62	1.32	12.2
Nonspecific LNP	Prime	8.98	27.44	1.1	3.54
Nonspecific LNP	Boost	9.6	49.39	1.07	2.12
PEGylated BSA	Prime	10.01	49.64	1.26	5.06
PEGylated BSA	Boost	8.87	169.14	1.11	17.25
Low molecular weight PEG	Prime	0.5	0.89	1	1.78
Low molecular weight PEG	Boost	0.61	1.78	1.22	9.29
BSA	Prime	5.43	5.38	0.92	0.96
BSA	Boost	5.78	8.06	0.98	1.44

Geometric mean (G.M.) of all the area under the curve (AUC) values measured after the prime or the boost are shown in the left panels. Geometric mean of fold induction (G.M.F.I) values, expressed as the ratio between prime or boost AUCs and the baseline AUC for each of the participants is shown in the right panels. Prime: First SARS-CoV-2 vaccine dose; Boost: Second SARS-CoV-2 vaccine dose.