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Exceptionally potent and broadly cross-reactive, bispecific multivalent HIV-1 inhibitors based on single human CD4 and antibody domains.

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Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population.

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Development of Small-Molecule MERS-CoV Inhibitors.

Liang R, Wang L, Zhang N, Deng X, Su M, Su Y, Hu L, He C, Ying T, Jiang S, Yu F

Viruses, 10(12):E721, 17 Dec 2018

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A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin.

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Cell Host Microbe, 22(4):471-483.e5, 28 Sep 2017

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Front Med, 11(4):462-470, 20 Nov 2017

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A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia.

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Front Oncol, 8:539, 22 Nov 2018

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Engineered soluble monomeric IgG1 CH3 domain: generation, mechanisms of function, and implications for design of biological therapeutics.

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J Biol Chem, 288(35):25154-25164, 18 Jul 2013

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Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections.

Ying T, Li H, Lu L, Dimitrov DS, Jiang S

Microbes Infect, 17(2):142-148, 29 Nov 2014

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A Human DPP4-Knockin Mouse's Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV.

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Viruses, 10(9):E448, 23 Aug 2018

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Engineered Fc based antibody domains and fragments as novel scaffolds.

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Biochim Biophys Acta, 1844(11):1977-1982, 02 May 2014

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Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III.

Wu Y, Li S, Du L, Wang C, Zou P, Hong B, Yuan M, Ren X, Tai W, Kong Y, Zhou C, Lu L, Zhou X, Jiang S, Ying T

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Bardhi A, Wu Y, Chen W, Li W, Zhu Z, Zheng JH, Wong H, Jeng E, Jones J, Ochsenbauer C, Kappes JC, Dimitrov DS, Ying T, Goldstein H

J Virol, 91(20):e00937-17, 27 Sep 2017

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A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants.

Yang Z, Wang Y, Jin Y, Zhu Y, Wu Y, Li C, Kong Y, Song W, Tian X, Zhan W, Huang A, Zhou S, Xia S, Tian X, Peng C, Chen C, Shi Y, Hu G, Du S, [...] Ying T

Signal Transduct Target Ther, 6(1):378, 03 Nov 2021

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A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III.

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PLoS Pathog, 15(6):e1007836, 26 Jun 2019

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Immune Repertoire Diversity Correlated with Mortality in Avian Influenza A (H7N9) Virus Infected Patients.

Hou D, Ying T, Wang L, Chen C, Lu S, Wang Q, Seeley E, Xu J, Xi X, Li T, Liu J, Tang X, Zhang Z, Zhou J, Bai C, Wang C, Byrne-Steele M, Qu J, Han J, Song Y

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Discovery of T-Cell Infection and Apoptosis by Middle East Respiratory Syndrome Coronavirus.

Ying T, Li W, Dimitrov DS

J Infect Dis, 213(6):877-879, 22 Jul 2015

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Fucoidan Extracted from the New Zealand Undaria pinnatifida-Physicochemical Comparison against Five Other Fucoidans: Unique Low Molecular Weight Fraction Bioactivity in Breast Cancer Cell Lines.

Lu J, Shi KK, Chen S, Wang J, Hassouna A, White LN, Merien F, Xie M, Kong Q, Li J, Ying T, White WL, Nie S

Mar Drugs, 16(12):E461, 22 Nov 2018

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Li H, Ying T, Yu F, Lu L, Jiang S

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Development of Small-Molecule Inhibitors Against Zika Virus Infection.

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Front Microbiol, 10:2725, 06 Dec 2019

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Interactions of IgG1 CH2 and CH3 Domains with FcRn.

Ying T, Ju TW, Wang Y, Prabakaran P, Dimitrov DS

Front Immunol, 5:146, 02 Apr 2014

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Monomeric IgG1 Fc molecules displaying unique Fc receptor interactions that are exploitable to treat inflammation-mediated diseases.

Ying T, Feng Y, Wang Y, Chen W, Dimitrov DS

MAbs, 6(5):1201-1210, 01 Jan 2014

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One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells.

Li W, Wu Y, Kong D, Yang H, Wang Y, Shao J, Feng Y, Chen W, Ma L, Ying T, Dimitrov DS

Sci Rep, 7(1):9130, 22 Aug 2017

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An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter gene.

Sun Z, Zhu Y, Wang Q, Ye L, Dai Y, Su S, Yu F, Ying T, Yang C, Jiang S, Lu L

Emerg Microbes Infect, 5:e65, 22 Jun 2016

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In-Depth Analysis of Human Neonatal and Adult IgM Antibody Repertoires.

Hong B, Wu Y, Li W, Wang X, Wen Y, Jiang S, Dimitrov DS, Ying T

Front Immunol, 9:128, 05 Feb 2018

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Bispecific engineered antibody domains (nanoantibodies) that interact noncompetitively with an HIV-1 neutralizing epitope and FcRn.

Gong R, Wang Y, Ying T, Dimitrov DS

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Ying T, Zhong F, Xie J, Feng Y, Wang ZH, Huang ZX, Tan X

J Bioenerg Biomembr, 41(3):251-257, 01 Jun 2009

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Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer.

Zhan W, Tian X, Zhang X, Xing S, Song W, Liu Q, Hao A, Hu Y, Zhang M, Ying T, Chen Z, Lan F, Sun L

J Virol, 96(16):e0048022, 04 Aug 2022

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Preparation, Characterization, and Immuno-Enhancing Activity of Polysaccharides from Glycyrrhiza uralensis.

Aipire A, Yuan P, Aimaier A, Cai S, Mahabati M, Lu J, Ying T, Zhang B, Li J

Biomolecules, 10(1):E159, 19 Jan 2020

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Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn.

Ying T, Wang Y, Feng Y, Prabakaran P, Gong R, Wang L, Crowder K, Dimitrov DS

MAbs, 7(5):922-930, 01 Jan 2015

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Antibody-based candidate therapeutics against HIV-1: implications for virus eradication and vaccine design.

Chen W, Ying T, Dimitrov DS

Expert Opin Biol Ther, 13(5):657-671, 07 Jan 2013

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Purification, characterization and bioactivities of polysaccharides from Pleurotus ferulae.

Li J, Yuan P, Wang X, Aipire A, Li M, Yang J, Tao H, Ying T, Fu C, Wei X, Zhang F, Li J

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Improving the CH1-CK heterodimerization and pharmacokinetics of 4Dm2m, a novel potent CD4-antibody fusion protein against HIV-1.

Chen W, Bardhi A, Feng Y, Wang Y, Qi Q, Li W, Zhu Z, Dyba MA, Ying T, Jiang S, Goldstein H, Dimitrov DS

MAbs, 8(4):761-774, 10 Mar 2016

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Discovery of novel candidate therapeutics and diagnostics based on engineered human antibody domains.

Chen W, Gong R, Ying T, Prabakaran P, Zhu Z, Feng Y, Dimitrov DS

Curr Drug Discov Technol, 11(1):28-40, 01 Mar 2014

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A native-like bispecific antibody suppresses the inflammatory cytokine response by simultaneously neutralizing tumor necrosis factor-alpha and interleukin-17A.

Xu T, Ying T, Wang L, Zhang XD, Wang Y, Kang L, Huang T, Cheng L, Wang L, Zhao Q

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Tyrosine-67 in cytochrome c is a possible apoptotic trigger controlled by hydrogen bonds via a conformational transition.

Ying T, Wang ZH, Lin YW, Xie J, Tan X, Huang ZX

Chem Commun (Camb), (30):4512-4514, 29 Jun 2009

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N-terminal truncation of an isolated human IgG1 CH2 domain significantly increases its stability and aggregation resistance.

Gong R, Wang Y, Ying T, Feng Y, Streaker E, Prabakaran P, Dimitrov DS

Mol Pharm, 10(7):2642-2652, 29 May 2013

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A Single Dose of Anti-HBsAg Antibody-Encoding mRNA-LNPs Suppressed HBsAg Expression: a Potential Cure of Chronic Hepatitis B Virus Infection.

Chen B, Chen Y, Li J, Wang C, Song W, Wen Y, Lin J, Wu Y, Ying T

mBio, 13(4):e0161222, 07 Jul 2022

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Structural basis for cytochrome c Y67H mutant to function as a peroxidase.

Lan W, Wang Z, Yang Z, Ying T, Zhang X, Tan X, Liu M, Cao C, Huang ZX

PLoS One, 9(9):e107305, 11 Sep 2014

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Efficient expression of human soluble guanylate cyclase in Escherichia coli and its signaling-related interaction with nitric oxide.

Zhong F, Wang H, Ying T, Huang ZX, Tan X

Amino Acids, 39(2):399-408, 09 Jan 2010

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Engineering a Novel Antibody-Peptide Bispecific Fusion Protein Against MERS-CoV.

Wang L, Xu J, Kong Y, Liang R, Li W, Li J, Lu J, Dimitrov DS, Yu F, Wu Y, Ying T

Antibodies (Basel), 8(4):E53, 04 Nov 2019

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Engineered Soluble Monomeric IgG1 Fc with Significantly Decreased Non-Specific Binding.

Wang C, Wu Y, Wang L, Hong B, Jin Y, Hu D, Chen G, Kong Y, Huang A, Hua G, Ying T

Front Immunol, 8:1545, 13 Nov 2017

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From therapeutic antibodies to chimeric antigen receptors (CARs): making better CARs based on antigen-binding domain.

Wu Y, Jiang S, Ying T

Expert Opin Biol Ther, 16(12):1469-1478, 19 Sep 2016

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Lu L, Xia S, Ying T, Jiang S

Emerg Microbes Infect, 4:e37, 17 Jun 2015

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Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants.

Hao A, Song W, Li C, Zhang X, Tu C, Wang X, Wang P, Wu Y, Ying T, Sun L

Signal Transduct Target Ther, 8(1):269, 08 Jul 2023

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A defucosylated bispecific multivalent molecule exhibits broad HIV-1-neutralizing activity and enhanced antibody-dependent cellular cytotoxicity against reactivated HIV-1 latently infected cells.

Kong D, Wang Y, Ji P, Li W, Ying T, Huang J, Wang C, Wu Y, Wang Y, Chen W, Hao Y, Hong K, Shao Y, Dimitrov DS, Jiang S, Ma L

AIDS, 32(13):1749-1761, 01 Aug 2018

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New Directions for Half-Life Extension of Protein Therapeutics: The Rise of Antibody Fc Domains and Fragments.

Wang L, Ying T

Curr Pharm Biotechnol, 17(15):1348-1352, 01 Jan 2016

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Recent Progress on Neutralizing Antibodies against Hepatitis B Virus and its Implications.

Hong B, Wen Y, Ying T

Infect Disord Drug Targets, 19(3):213-223, 01 Jan 2019

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Escape from humoral immunity is associated with treatment failure in HIV-1-infected patients receiving long-term antiretroviral therapy.

Ouyang Y, Yin Q, Li W, Li Z, Kong D, Wu Y, Hong K, Xing H, Shao Y, Jiang S, Ying T, Ma L

Sci Rep, 7(1):6222, 24 Jul 2017

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Evaluation of antiviral - passive - active immunization ("sandwich") therapeutic strategy for functional cure of chronic hepatitis B in mice.

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EBioMedicine, 49:247-257, 01 Nov 2019

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Rapid Elimination of Broadly Neutralizing Antibodies Correlates with Treatment Failure in the Acute Phase of Simian-Human Immunodeficiency Virus Infection.

Wu Y, Xue J, Wang C, Li W, Wang L, Chen W, Prabakaran P, Kong D, Jin Y, Hu D, Wang Y, Lei C, Yu D, Tu C, Bardhi A, Sidorov I, Ma L, Goldstein H, Qin C, [...] Ying T

J Virol, 93(20):e01077-19, 30 Sep 2019

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Distinct mechanisms for the pro-apoptotic conformational transition and alkaline transition in cytochrome c.

Ying T, Wang ZH, Zhong F, Tan X, Huang ZX

Chem Commun (Camb), 46(20):3541-3543, 09 Apr 2010

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Single-Domain Antibodies as Therapeutics for Respiratory RNA Virus Infections.

Huang K, Ying T, Wu Y

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The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2.

Tian X, Zhu X, Song W, Yang Z, Wu Y, Ying T

Emerg Microbes Infect, 11(1):1186-1190, 01 Dec 2022

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Investigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand Undaria pinnatifida in Combination with GroA Therapy in Prostate Cancer Cell Lines.

Yang X, Wang S, Trangle SS, Li Y, White WL, Li J, Ying T, Kong Q, Zhao Y, Lu J

Mar Drugs, 16(11):E454, 18 Nov 2018

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Conformational toggling of yeast iso-1-cytochrome C in the oxidized and reduced states.

Lan W, Wang Z, Yang Z, Zhu J, Ying T, Jiang X, Zhang X, Wu H, Liu M, Tan X, Cao C, Huang ZX

PLoS One, 6(11):e27219, 08 Nov 2011

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A novel insight into the heme and NO/CO binding mechanism of the alpha subunit of human soluble guanylate cyclase.

Zhong F, Pan J, Liu X, Wang H, Ying T, Su J, Huang ZX, Tan X

J Biol Inorg Chem, 16(8):1227-1239, 02 Jul 2011

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Probing the role of the bridging C509 between the [Fe4S4] cubane and the [Ni(p)Ni(d)] centre in the A-cluster of acetyl-coenzyme A synthase.

Liu Y, Zhu X, Wang F, Ying T, Li P, Huang ZX, Tan X

Chem Commun (Camb), 47(4):1291-1293, 22 Nov 2010

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High Glucose Promotes Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance and Invasion through Modulating ROS/MMP-3 Signaling Pathway.

Deng J, Guo Y, Hu X, Du J, Gu J, Kong L, Tao B, Fu D, Ying T, Li J

Oxid Med Cell Longev, 2022:3243647, 29 Sep 2022

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A route to novel functional metalloproteins via hybrids of cytochrome P450 and cytochrome c.

Ying T, Zhong F, Wang ZH, Li W, Tan X, Huang ZX

Chembiochem, 12(5):707-710, 03 Feb 2011

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Potent Therapeutic Strategies for COVID-19 with Single-Domain Antibody Immunoliposomes Neutralizing SARS-CoV-2 and Lip/cGAMP Enhancing Protective Immunity.

Zhou Y, Lu X, Wang X, Ying T, Tan X

Int J Mol Sci, 24(4):4068, 17 Feb 2023

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Generation of novel functional metalloproteins via hybrids of cytochrome c and peroxidase.

Ying T, Zhong F, Wang ZH, Xie J, Tan X, Huang ZX

Protein Eng Des Sel, 26(6):401-407, 20 Mar 2013

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Single-domain antibodies as therapeutics for solid tumor treatment.

Wang M, Ying T, Wu Y

Acta Pharm Sin B, 14(7):2854-2868, 15 Mar 2024

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Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers.

Yin D, Zhong Y, Ling S, Lu S, Wang X, Jiang Z, Wang J, Dai Y, Tian X, Huang Q, Wang X, Chen J, Li Z, Li Y, Xu Z, Jiang H, Wu Y, Shi Y, Wang Q, [...] Cai Y

Nat Biomed Eng, 07 May 2024

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Design of a Novel Fab-Like Antibody Fragment with Enhanced Stability and Affinity for Clinical use.

Wang C, Hong J, Yang Z, Zhou X, Yang Y, Kong Y, Chen B, Wu H, Qian BZ, Dimitrov DS, Zhou X, Wu Y, Ying T

Small Methods, 6(2):e2100966, 28 Nov 2021

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Editorial: Antibody Fc Engineering: Towards Better Therapeutics.

Lei C, Gong R, Ying T

Front Immunol, 9:2450, 24 Oct 2018

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A systems approach to HIV-1 vaccines.

Ying T, Prabakaran P, Dimitrov DS

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Germlining of the HIV-1 broadly neutralizing antibody domain m36.

Chen W, Li W, Ying T, Wang Y, Feng Y, Dimitrov DS

Antiviral Res, 116:62-66, 09 Feb 2015

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Manganese superoxide dismutase from human pathogen Clostridium difficile.

Li W, Wang H, Lei C, Ying T, Tan X

Amino Acids, 47(5):987-995, 06 Feb 2015

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Pretrainable geometric graph neural network for antibody affinity maturation.

Cai H, Zhang Z, Wang M, Zhong B, Li Q, Zhong Y, Wu Y, Ying T, Tang J

Nat Commun, 15(1):7785, 06 Sep 2024

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Efficacy and safety of novel multifunctional M10 CAR-T cells in HIV-1-infected patients: a phase I, multicenter, single-arm, open-label study.

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Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

Tian X, Li C, Huang A, Xia S, Lu S, Shi Z, Lu L, Jiang S, Yang Z, Wu Y, Ying T

bioRxiv, 28 Jan 2020

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Fc Engineering: Tailored Synthetic Human IgG1-Fc Repertoire for High-Affinity Interaction with FcRn at pH 6.0.

Saxena A, Bai B, Hou SC, Jiang L, Ying T, Miersch S, Sidhu SS, Wu D

Methods Mol Biol, 1827:399-417, 01 Jan 2018

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N-Butanol Subfraction of Brassica Rapa L. Promotes Reactive Oxygen Species Production and Induces Apoptosis of A549 Lung Adenocarcinoma Cells via Mitochondria-Dependent Pathway.

Aipire A, Chen Q, Cai S, Li J, Fu C, Ying T, Lu J, Li J

Molecules, 23(7):E1687, 11 Jul 2018

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Precision immunomedicine.

Ying T, Wen Y, Dimitrov DS

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No evidence for a superior platform to develop therapeutic antibodies rapidly in response to MERS-CoV and other emerging viruses.

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Proc Natl Acad Sci U S A, 112(37):E5115, 28 Aug 2015

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Author Correction: Pretrainable geometric graph neural network for antibody affinity maturation.

Cai H, Zhang Z, Wang M, Zhong B, Li Q, Zhong Y, Wu Y, Ying T, Tang J

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