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Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies.
Mullins SR, Vasilakos JP, Deschler K, Grigsby I, Gillis P, John J, Elder MJ, Swales J, Timosenko E, Cooper Z, Dovedi SJ, Leishman AJ, Luheshi N, Elvecrog J, Tilahun A, Goodwin R, Herbst R, Tomai MA, Wilkinson RW
J Immunother Cancer, 7(1):244, 11 Sep 2019
Cited by: 94 articles | PMID: 31511088 | PMCID: PMC6739946
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Further Advances in Cancer Immunotherapy: Going Beyond Checkpoint Blockade.
Wilkinson RW, Leishman AJ
Front Immunol, 9:1082, 01 Jun 2018
Cited by: 12 articles | PMID: 29910800 | PMCID: PMC5992967
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Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141⁺ Subset.
Sachamitr P, Leishman AJ, Davies TJ, Fairchild PJ
Front Immunol, 8:1935, 08 Jan 2018
Cited by: 27 articles | PMID: 29358940 | PMCID: PMC5766641
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Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy.
Williams GS, Mistry B, Guillard S, Ulrichsen JC, Sandercock AM, Wang J, González-Muñoz A, Parmentier J, Black C, Soden J, Freeth J, Jovanović J, Leyland R, Al-Lamki RS, Leishman AJ, Rust SJ, Stewart R, Jermutus L, Bradley JR, [...] Wilkinson RW
Oncotarget, 7(42):68278-68291, 01 Oct 2016
Cited by: 32 articles | PMID: 27626702 | PMCID: PMC5356554
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Harnessing the immunomodulatory capacity of dendritic cells differentiated from human induced pluripotent stem cells and the therapeutic potential of dendritic cell-derived exosomes for the treatment of lysosomal storage diseases
Leishman AJ
University of Oxford, 01 Jan 2015
Cited by: 0 articles | ETH: 730559
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Mechanism of action of inhibition of allergic immune responses by a novel antedrug TLR7 agonist.
Matsui H, Tomizawa H, Eiho K, Kashiwazaki Y, Edwards S, Biffen M, Bell JP, Bahl A, Leishman AJ, Murray CM, Takaku H, Ueda Y
J Immunol, 189(11):5194-5205, 02 Nov 2012
Cited by: 13 articles | PMID: 23125414
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Harnessing the immonomodulatory capacity of dendritic cells differentiated from human induced pluripotent stem cells and the therapeutic potential of dendritic cell-derived exosomes for the treatment of lysosomal storage diseases
Leishman AJ
University of Oxford, 01 Jan 2014
Cited by: 0 articles | ETH: 711748
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An anti-human ICAM-1 antibody inhibits rhinovirus-induced exacerbations of lung inflammation.
Traub S, Nikonova A, Carruthers A, Dunmore R, Vousden KA, Gogsadze L, Hao W, Zhu Q, Bernard K, Zhu J, Dymond M, McLean GR, Walton RP, Glanville N, Humbles A, Khaitov M, Wells T, Kolbeck R, Leishman AJ, [...] Johnston SL
PLoS Pathog, 9(8):e1003520, 01 Aug 2013
Cited by: 51 articles | PMID: 23935498 | PMCID: PMC3731244
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TLR7 stimulation of APCs results in inhibition of IL-5 through type I IFN and Notch signaling pathways in human peripheral blood mononuclear cells.
Edwards S, Jones C, Leishman AJ, Young BW, Matsui H, Tomizawa H, Murray CM, Biffen M
J Immunol, 190(6):2585-2592, 04 Feb 2013
Cited by: 13 articles | PMID: 23382558
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Intratracheal and oral administration of SM-276001: a selective TLR7 agonist, leads to antitumor efficacy in primary and metastatic models of cancer.
Koga-Yamakawa E, Dovedi SJ, Murata M, Matsui H, Leishman AJ, Bell J, Ferguson D, Heaton SP, Oki T, Tomizawa H, Bahl A, Takaku H, Wilkinson RW, Harada H
Int J Cancer, 132(3):580-590, 11 Jul 2012
Cited by: 19 articles | PMID: 22733292
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Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity.
Biffen M, Matsui H, Edwards S, Leishman AJ, Eiho K, Holness E, Satterthwaite G, Doyle I, Wada H, Fraser NJ, Hawkins SL, Aoki M, Tomizawa H, Benjamin AD, Takaku H, McInally T, Murray CM
Br J Pharmacol, 166(2):573-586, 01 May 2012
Cited by: 24 articles | PMID: 22122192 | PMCID: PMC3417490
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Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype.
Silk KM, Leishman AJ, Nishimoto KP, Reddy A, Fairchild PJ
J Biomed Biotechnol, 2012:172420, 07 Feb 2012
Cited by: 3 articles | PMID: 22505805 | PMCID: PMC3303870
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Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.
Silk KM, Silk JD, Ichiryu N, Davies TJ, Nolan KF, Leishman AJ, Carpenter L, Watt SM, Cerundolo V, Fairchild PJ
Gene Ther, 19(10):1035-1040, 10 Nov 2011
Cited by: 35 articles | PMID: 22071967
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Pharmacological manipulation of dendritic cells in the pursuit of transplantation tolerance.
Leishman AJ, Silk KM, Fairchild PJ
Curr Opin Organ Transplant, 16(4):372-378, 01 Aug 2011
Cited by: 8 articles | PMID: 21666481
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Emerging small molecule and biological therapeutic approaches for the treatment of autoimmunity.
Leishman AJ, Sims GP, Sleeman M, Braddock M
Expert Opin Investig Drugs, 20(1):23-39, 01 Dec 2010
Cited by: 2 articles | PMID: 21118058
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An investigation of the impact of the location and timing of antigen-specific T cell division on airways inflammation.
Hutchison S, Choo-Kang BS, Gibson VB, Bundick RV, Leishman AJ, Brewer JM, McInnes IB, Garside P
Clin Exp Immunol, 155(1):107-116, 01 Jan 2009
Cited by: 7 articles | PMID: 19076834
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CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans.
Campbell JD, Cho Y, Foster ML, Kanzler H, Kachura MA, Lum JA, Ratcliffe MJ, Sathe A, Leishman AJ, Bahl A, McHale M, Coffman RL, Hessel EM
J Clin Invest, 119(9):2564-2576, 10 Aug 2009
Cited by: 45 articles | PMID: 19726873 | PMCID: PMC2735936
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CD4+ CD25+ regulatory T cells: a therapeutic target for liver diseases.
Zheng MH, Gu DN, Braddock M, Leishman AJ, Jin C, Wen JS, Gong YW, Chen YP
Expert Opin Ther Targets, 12(3):313-326, 01 Mar 2008
Cited by: 5 articles | PMID: 18269341
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Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritis.
Nickdel MB, Conigliaro P, Valesini G, Hutchison S, Benson R, Bundick RV, Leishman AJ, McInnes IB, Brewer JM, Garside P
Ann Rheum Dis, 68(6):1059-1066, 17 Jul 2008
Cited by: 21 articles | PMID: 18635595
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Tumour necrosis factor-alpha blockade suppresses murine allergic airways inflammation.
Hutchison S, Choo-Kang BS, Bundick RV, Leishman AJ, Brewer JM, McInnes IB, Garside P
Clin Exp Immunol, 151(1):114-122, 11 Oct 2007
Cited by: 36 articles | PMID: 17931392
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7th EFIS Tatra Immunology Conference. Molecular determinants of T-cell immunity. 24-28 June 2006, High Tatra Mountains, Slovakia.
Leishman AJ
Expert Opin Investig Drugs, 15(10):1283-1289, 01 Oct 2006
Cited by: 0 articles | PMID: 16989603
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TNF-blocking therapies: an alternative mode of action?
Choo-Kang BS, Hutchison S, Nickdel MB, Bundick RV, Leishman AJ, Brewer JM, McInnes IB, Garside P
Trends Immunol, 26(10):518-522, 01 Oct 2005
Cited by: 30 articles | PMID: 16087401
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Immunology: turning basic research into a therapy.
Leishman AJ, Bundick RV
Immunol Lett, 99(1):1-7, 12 Jan 2005
Cited by: 0 articles | PMID: 15894103
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NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells.
Elewaut D, Shaikh RB, Hammond KJ, De Winter H, Leishman AJ, Sidobre S, Turovskaya O, Prigozy TI, Ma L, Banks TA, Lo D, Ware CF, Cheroutre H, Kronenberg M
J Exp Med, 197(12):1623-1633, 01 Jun 2003
Cited by: 91 articles | PMID: 12810685 | PMCID: PMC2193960
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Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides.
Leishman AJ, Gapin L, Capone M, Palmer E, MacDonald HR, Kronenberg M, Cheroutre H
Immunity, 16(3):355-364, 01 Mar 2002
Cited by: 145 articles | PMID: 11911821
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