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Search life-sciences literature (45,103,589 articles, preprints and more)

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A Human Brain-Chip for Modeling Brain Pathologies and Screening Blood-Brain Barrier Crossing Therapeutic Strategies.
Chim SM, Howell K, Kokkosis A, Zambrowicz B, Karalis K, Pavlopoulos E
Pharmaceutics, 16(10):1314, 10 Oct 2024
Cited by: 0 articles | PMID: 39458643 | PMCID: PMC11510380
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Transferrin receptor targeting chimeras for membrane protein degradation.
Zhang D, Duque-Jimenez J, Facchinetti F, Brixi G, Rhee K, Feng WW, Jänne PA, Zhou X
Nature, 25 Sep 2024
Cited by: 4 articles | PMID: 39322661
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The diagnosis and management of mucopolysaccharidosis type II.
Mao SJ, Chen QQ, Dai YL, Dong GP, Zou CC
Ital J Pediatr, 50(1):207, 08 Oct 2024
Cited by: 0 articles | PMID: 39380047 | PMCID: PMC11463001
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Targeting Neurological Aspects of Mucopolysaccharidosis Type II: Enzyme Replacement Therapy and Beyond.
Zanetti A, Tomanin R
BioDrugs, 38(5):639-655, 23 Aug 2024
Cited by: 0 articles | PMID: 39177874 | PMCID: PMC11358193
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Engineered Antibodies to Improve Efficacy against Neurodegenerative Disorders.
Niazi SK, Mariam Z, Magoola M
Int J Mol Sci, 25(12):6683, 18 Jun 2024
Cited by: 2 articles | PMID: 38928395
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Molecular therapy and nucleic acid adeno-associated virus-based gene therapy delivering combinations of two growth-associated genes to MPS IVA mice.
Rintz E, Celik B, Fnu N, Herreño-Pachón AM, Khan S, Benincore-Flórez E, Tomatsu S
Mol Ther Nucleic Acids, 35(2):102211, 07 May 2024
Cited by: 0 articles | PMID: 38831899 | PMCID: PMC11145352
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α-L-iduronidase fused with humanized anti-human transferrin receptor antibody (lepunafusp alfa) for mucopolysaccharidosis type I: A phase 1/2 trial.
Harmatz P, Giugliani R, Martins AM, Hamazaki T, Kubo T, Kira R, Minami K, Ikeda T, Moriuchi H, Kawashima S, Takasao N, So S, Sonoda H, Hirato T, Tanizawa K, Schmidt M, Sato Y
Mol Ther, 32(3):609-618, 10 Jan 2024
Cited by: 1 article | PMID: 38204164
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Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood-brain barrier and interacts with amyloid β.
Faresjö R, Sjöström EO, Dallas T, Berglund MM, Eriksson J, Sehlin D, Syvänen S
MAbs, 16(1):2410968, 01 Jan 2024
Cited by: 0 articles | PMID: 39358860 | PMCID: PMC11451328
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Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery.
Porro GM, Lorandi I, Liu X, Kataoka K, Battaglia G, Gonzalez-Carter D
Fluids Barriers CNS, 20(1):88, 06 Dec 2023
Cited by: 0 articles | PMID: 38053174 | PMCID: PMC10699038
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Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the Blood-Retinal Barrier and Improves Retinopathy in Mucopolysaccharidosis II Mice.
Imakiire A, Morimoto H, Suzuki H, Masuda T, Yoden E, Inoue A, Morioka H, Konaka T, Mori A, Shirasaka R, Kato R, Hirato T, Sonoda H, Minami K
Mol Pharm, 20(11):5901-5909, 20 Oct 2023
Cited by: 1 article | PMID: 37860991 | PMCID: PMC10630942
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Enhanced osteoblastic differentiation of parietal bone in a novel murine model of mucopolysaccharidosis type II.
Yamazaki N, Ohira M, Takada S, Ohtake A, Onodera M, Nakanishi M, Okuyama T, Mashima R
Mol Genet Metab Rep, 37:101021, 11 Nov 2023
Cited by: 0 articles | PMID: 38053930 | PMCID: PMC10694741
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Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs.
Pornnoppadol G, Bond LG, Lucas MJ, Zupancic JM, Kuo YH, Zhang B, Greineder CF, Tessier PM
Cell Chem Biol, 31(2):361-372.e8, 26 Oct 2023
Cited by: 8 articles | PMID: 37890480
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Bringing enzymes to the proximity party.
Tender GS, Bertozzi CR
RSC Chem Biol, 4(12):986-1002, 29 Sep 2023
Cited by: 5 articles | PMID: 38033727 | PMCID: PMC10685825
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Proteomic alterations in the brain and blood-brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer's disease.
Ito S, Yagi R, Ogata S, Masuda T, Saito T, Saido T, Ohtsuki S
Fluids Barriers CNS, 20(1):66, 14 Sep 2023
Cited by: 3 articles | PMID: 37705104 | PMCID: PMC10500766
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Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody.
Esparza TJ, Su S, Francescutti CM, Rodionova E, Kim JH, Brody DL
Fluids Barriers CNS, 20(1):64, 24 Aug 2023
Cited by: 2 articles | PMID: 37620930 | PMCID: PMC10463325
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Receptor-mediated drug delivery of bispecific therapeutic antibodies through the blood-brain barrier.
Pardridge WM
Front Drug Deliv, 3:1227816, 10 Jul 2023
Cited by: 4 articles | PMID: 37583474 | PMCID: PMC10426772
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Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics.
Rué L, Jaspers T, Degors IMS, Noppen S, Schols D, De Strooper B, Dewilde M
Pharmaceutics, 15(6):1748, 16 Jun 2023
Cited by: 3 articles | PMID: 37376196 | PMCID: PMC10300862
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A novel mucopolysaccharidosis type II mouse model with an iduronate-2-sulfatase-P88L mutation.
Mashima R, Ohira M, Okuyama T, Onodera M, Takada S
Sci Rep, 13(1):7865, 15 May 2023
Cited by: 1 article | PMID: 37188686 | PMCID: PMC10185571
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Enzyme replacement with transferrin receptor-targeted α-L-iduronidase rescues brain pathology in mucopolysaccharidosis I mice.
Kida S, Koshimura Y, Yoden E, Yoshioka A, Morimoto H, Imakiire A, Tanaka N, Tanaka S, Mori A, Ito J, Inoue A, Yamamoto R, Minami K, Hirato T, Takahashi K, Sonoda H
Mol Ther Methods Clin Dev, 29:439-449, 12 May 2023
Cited by: 9 articles | PMID: 37251981 | PMCID: PMC10220318
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Characterization of a HIR-Fab-IDS, Novel Iduronate 2-Sulfatase Fusion Protein for the Treatment of Neuropathic Mucopolysaccharidosis Type II (Hunter Syndrome).
Gusarova VD, Smolov MA, Lyagoskin IV, Degterev MB, Rechetnik EV, Rodionov AV, Pantyushenko MS, Shukurov RR
BioDrugs, 37(3):375-395, 04 Apr 2023
Cited by: 0 articles | PMID: 37014547
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Mechanisms of Resistance and Current Treatment Options for Glioblastoma Multiforme (GBM).
Yalamarty SSK, Filipczak N, Li X, Subhan MA, Parveen F, Ataide JA, Rajmalani BA, Torchilin VP
Cancers (Basel), 15(7):2116, 01 Apr 2023
Cited by: 31 articles | PMID: 37046777 | PMCID: PMC10093719
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Individual Treatment Trials-Do Experts Know and Use This Option to Improve the Treatability of Mucopolysaccharidosis?
Wiesinger AM, Strobl H, Lagler FB
Pharmaceuticals (Basel), 16(3):416, 09 Mar 2023
Cited by: 2 articles | PMID: 36986515 | PMCID: PMC10058611
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Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct.
Gehrlein A, Udayar V, Anastasi N, Morella ML, Ruf I, Brugger D, von der Mark S, Thoma R, Rufer A, Heer D, Pfahler N, Jochner A, Niewoehner J, Wolf L, Fueth M, Ebeling M, Villaseñor R, Zhu Y, Deen MC, [...] Jagasia R
Nat Commun, 14(1):2057, 12 Apr 2023
Cited by: 12 articles | PMID: 37045813 | PMCID: PMC10097658
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CDR3 Variants of the TXB2 Shuttle with Increased TfR1 Association Rate and Enhanced Brain Penetration.
Stocki P, Szary J, Demydchuk M, Northall L, Rasmussen CLM, Logan DB, Gauhar A, Thei L, Coker SF, Moos T, Walsh FS, Rutkowski JL
Pharmaceutics, 15(3):739, 23 Feb 2023
Cited by: 3 articles | PMID: 36986599 | PMCID: PMC10051654
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Application of Antisense Conjugates for the Treatment of Myotonic Dystrophy Type 1.
Stoodley J, Vallejo-Bedia F, Seone-Miraz D, Debasa-Mouce M, Wood MJA, Varela MA
Int J Mol Sci, 24(3):2697, 31 Jan 2023
Cited by: 4 articles | PMID: 36769018 | PMCID: PMC9916419
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