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Search life-sciences literature (45,100,050 articles, preprints and more)

Suggested authors matching "AUTH:Abell C" with an ORCID

Chris Abell
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Fragment-based development of small molecule inhibitors targetingMycobacterium tuberculosischolesterol metabolism
Kavanagh ME, McLean KJ, Gilbert SH, Amadi C, Snee M, Tunnicliffe RB, Arora K, Boshoff HI, Fanourakis A, Rebello-Lopez MJ, Ortega-Muro F, Levy CW, Munro AW, Leys D, Abell C, Coyne AG
bioRxiv, 31 Oct 2024
Cited by: 0 articles | PPR: PPR933415
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Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents.
Stockwell SR, Scott DE, Fischer G, Guarino E, Rooney TPC, Feng TS, Moschetti T, Srinivasan R, Alza E, Asteian A, Dagostin C, Alcaide A, Rocaboy M, Blaszczyk B, Higueruelo A, Wang X, Rossmann M, Perrior TR, Blundell TL, [...] Hyvönen M
J Med Chem, 67(17):15521-15536, 27 Aug 2024
Cited by: 0 articles | PMID: 39190548 | PMCID: PMC11403621
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A Fragment-Based Competitive ¹⁹F LB-NMR Platform For Hotspot-Directed Ligand Profiling.
McCarthy WJ, Thomas SE, Olaleye T, Boland JA, Floto RA, Williams G, Blundell TL, Coyne AG, Abell C
Angew Chem Int Ed Engl, 63(37):e202406846, 12 Aug 2024
Cited by: 0 articles | PMID: 38896426
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Fragment-Merging Strategies with Known Pyrimidine Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
Kirkman T, Fun Tan S, Chavez-Pacheco SM, Hammer A, Abell C, Tosin M, Coyne AG, Dias MVB
ChemMedChem, 18(15):e202300240, 06 Jun 2023
Cited by: 0 articles | PMID: 37195570
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Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Katariya MM, Snee M, Tunnicliffe RB, Kavanagh ME, Boshoff HIM, Amadi CN, Levy CW, Munro AW, Abell C, Leys D, Coyne AG, McLean KJ
Chemistry, 29(29):e202203868, 12 Apr 2023
Cited by: 3 articles | PMID: 36912255 | PMCID: PMC10205683
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Selective Aurora A-TPX2 interaction inhibitors havein vivoefficacy as targeted anti-mitotic agents
Stockwell SR, Scott DE, Fischer G, Guarino E, Rooney TPC, Feng T, Moschetti T, Srinivasan R, Alza E, Asteian A, Dagostin C, Alcaide A, Rocaboy M, Blaszczyk B, Higueruelo A, Wang X, Rossmann M, Perrior TR, Blundell TL, [...] Hyvönen M
bioRxiv, 22 Mar 2023
Cited by: 0 articles | PPR: PPR634859
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Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.
El Bakali J, Blaszczyk M, Evans JC, Boland JA, McCarthy WJ, Fathoni I, Dias MVB, Johnson EO, Coyne AG, Mizrahi V, Blundell TL, Abell C, Spry C
Angew Chem Int Ed Engl, 62(17):e202300221, 13 Mar 2023
Cited by: 6 articles | PMID: 36757665 | PMCID: PMC10947119
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Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target.
Howieson VM, Zeng J, Kloehn J, Spry C, Marchetti C, Lunghi M, Varesio E, Soper A, Coyne AG, Abell C, van Dooren GG, Saliba KJ
Int J Parasitol Drugs Drug Resist, 22:1-8, 15 Mar 2023
Cited by: 0 articles | PMID: 37004488 | PMCID: PMC10102396
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Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.
El Bakali J, Blaszczyk M, Evans JC, Boland JA, McCarthy WJ, Fathoni I, Dias MVB, Johnson EO, Coyne AG, Mizrahi V, Blundell TL, Abell C, Spry C
Angew Chem Weinheim Bergstr Ger, 135(17):e202300221, 13 Mar 2023
Cited by: 0 articles | PMID: 38515507 | PMCID: PMC10952327
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Microfluidic preparation of composite hydrogel microparticles for the staining of microalgal cells.
Leontidou T, Yu Z, Hess J, Geisler K, Smith AG, Coyne A, Abell C
Colloids Surf B Biointerfaces, 221:113026, 15 Nov 2022
Cited by: 1 article | PMID: 36410191
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Development of potent inhibitors by fragment-linking strategies.
Bedwell EV, McCarthy WJ, Coyne AG, Abell C
Chem Biol Drug Des, 100(4):469-486, 16 Aug 2022
Cited by: 2 articles | PMID: 35854428
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Structural-guided fragment-based drug discovery applied to antitoxin, MAB3862 opens a new possibility of exploring the Toxin and Antitoxin for antibiotics
Kim SY, Eun H, Lee J, Lee W, Thomas SE, Brear P, Vedithi SC, Abell C, Lee B, Blundell TL
bioRxiv, 15 May 2022
Cited by: 0 articles | PPR: PPR504249
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Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design.
Thomas SE, McCarthy WJ, El Bakali J, Brown KP, Kim SY, Blaszczyk M, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL
Front Mol Biosci, 9:880432, 30 May 2022
Cited by: 4 articles | PMID: 35712348 | PMCID: PMC9197168
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Increasing computational protein design literacy through cohort-based learning for undergraduate students
Yang EC, Divine R, Kang CS, Chan S, Arenas E, Subol Z, Tinker P, Manninen H, Feichtenbiner A, Mustafa T, Hallowell J, Orr I, Haddox H, Koepnick B, O’Connor J, Haydon IC, Herpoldt K, Van Wormer K, Abell C, [...] King NP
bioRxiv, 25 May 2022
Cited by: 0 articles | PPR: PPR498076
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Author Correction: Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles.
Abalde-Cela S, Taladriz-Blanco P, de Oliveira MG, Abell C
Sci Rep, 12(1):6559, 21 Apr 2022
Cited by: 0 articles | PMID: 35449184 | PMCID: PMC9023446
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Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility.
Douthwaite JA, Brown CA, Ferdinand JR, Sharma R, Elliott J, Taylor MA, Malintan NT, Duvoisin H, Hill T, Delpuech O, Orton AL, Pitt H, Kuenzi F, Fish S, Nicholls DJ, Cuthbert A, Richards I, Ratcliffe G, Upadhyay A, [...] Clark R
Sci Rep, 12(1):3114, 24 Feb 2022
Cited by: 2 articles | PMID: 35210470 | PMCID: PMC8873195
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Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.
Aggarwal D, Warne B, Jahun AS, Hamilton WL, Fieldman T, du Plessis L, Hill V, Blane B, Watkins E, Wright E, Hall G, Ludden C, Myers R, Hosmillo M, Chaudhry Y, Pinckert ML, Georgana I, Izuagbe R, Leek D, [...] Goodfellow IG
Nat Commun, 13(1):751, 08 Feb 2022
Cited by: 23 articles | PMID: 35136068 | PMCID: PMC8826310
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Potential therapeutic targets from Mycobacterium abscessus (Mab): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections.
Addison W, Frederickson M, Coyne AG, Abell C
RSC Med Chem, 13(4):392-404, 10 Mar 2022
Cited by: 1 article | PMID: 35647542 | PMCID: PMC9020770
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Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
Charoensutthivarakul S, Thomas SE, Curran A, Brown KP, Belardinelli JM, Whitehouse AJ, Acebrón-García-de-Eulate M, Sangan J, Gramani SG, Jackson M, Mendes V, Floto RA, Blundell TL, Coyne AG, Abell C
ACS Infect Dis, 8(2):296-309, 17 Jan 2022
Cited by: 7 articles | PMID: 35037462 | PMCID: PMC7614835
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A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).
Frederickson M, Selvam IR, Evangelopoulos D, McLean KJ, Katariya MM, Tunnicliffe RB, Campbell B, Kavanagh ME, Charoensutthivarakul S, Blankley RT, Levy CW, de Carvalho LPS, Leys D, Munro AW, Coyne AG, Abell C
Eur J Med Chem, 230:114105, 11 Jan 2022
Cited by: 2 articles | PMID: 35065413 | PMCID: PMC8856928
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Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.
Acebrón-García-de-Eulate M, Mayol-Llinàs J, Holland MTO, Kim SY, Brown KP, Marchetti C, Hess J, Di Pietro O, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL
J Med Chem, 65(3):2149-2173, 26 Jan 2022
Cited by: 2 articles | PMID: 35080396 | PMCID: PMC7614804
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An iteratively optimised process for improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility
Douthwaite JA, Brown CA, Ferdinand JR, Sharma R, Elliott J, Taylor M, Malintan NT, Duvoisin H, Hill T, Delpuech O, Orton AL, Pitt H, Kuenzi F, Fish S, Nicholls DJ, Cuthbert A, Richards I, Ratcliffe G, Upadhyay A, [...] Clark R
Research Square, 29 Jun 2021
Cited by: 0 articles | PPR: PPR363257
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A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.
Gupta P, Thomas SE, Zaidan SA, Pasillas MA, Cory-Wright J, Sebastián-Pérez V, Burgess A, Cattermole E, Meghir C, Abell C, Coyne AG, Jacobs WR, Blundell TL, Tiwari S, Mendes V
Comput Struct Biotechnol J, 19:3491-3506, 04 Jun 2021
Cited by: 12 articles | PMID: 34194673 | PMCID: PMC8220418
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Droplet-based microfluidic screening and sorting of microalgal populations for strain engineering applications.
Yu Z, Geisler K, Leontidou T, Young REB, Vonlanthen SE, Purton S, Abell C, Smith AG
Algal Res, 56:None, 01 Jun 2021
Cited by: 9 articles | PMID: 34084707 | PMCID: PMC8139872
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Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4'-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity.
Evans JC, Murugesan D, Post JM, Mendes V, Wang Z, Nahiyaan N, Lynch SL, Thompson S, Green SR, Ray PC, Hess J, Spry C, Coyne AG, Abell C, Boshoff HIM, Wyatt PG, Rhee KY, Blundell TL, Barry CE, Mizrahi V
ACS Infect Dis, 7(6):1666-1679, 03 May 2021
Cited by: 2 articles | PMID: 33939919 | PMCID: PMC8205227
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Search life-sciences literature (45,100,050 articles, preprints and more)

Suggested authors matching "AUTH:Abell C" with an ORCID

Search results

Fragment-based development of small molecule inhibitors targetingMycobacterium tuberculosischolesterol metabolism

Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents.

A Fragment-Based Competitive ¹⁹F LB-NMR Platform For Hotspot-Directed Ligand Profiling.

Fragment-Merging Strategies with Known Pyrimidine Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.

Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.

Selective Aurora A-TPX2 interaction inhibitors havein vivoefficacy as targeted anti-mitotic agents

Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.

Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target.

Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.

Microfluidic preparation of composite hydrogel microparticles for the staining of microalgal cells.

Development of potent inhibitors by fragment-linking strategies.

Structural-guided fragment-based drug discovery applied to antitoxin, MAB3862 opens a new possibility of exploring the Toxin and Antitoxin for antibiotics

Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design.

Increasing computational protein design literacy through cohort-based learning for undergraduate students

Author Correction: Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles.

Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility.

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.

Potential therapeutic targets from Mycobacterium abscessus (Mab): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections.

Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).

Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.

An iteratively optimised process for improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility

A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.

Droplet-based microfluidic screening and sorting of microalgal populations for strain engineering applications.

Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4'-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity.

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