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Search life-sciences literature (45,103,589 articles, preprints and more)

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Overexpression of Il-6 in Bleomycin-Treated Balb/C Mice Provides a New Model of Lung Fibrosis: Transcriptomic Comparison to Human Ipf
Richards CD, Ayaub E, Botelho F, Dvorkin-Gheva A, Vierhout M, Naiel S, Abed S, Kolb M, Ask K
Preprints.org, 30 Jul 2024
Cited by: 0 articles | PPR: PPR895799
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Myeloid-specific deletion of activating transcription factor 6 alpha increases CD11b⁺ macrophage subpopulations and aggravates lung fibrosis.
Mekhael O, Revill SD, Hayat AI, Cass SP, MacDonald K, Vierhout M, Ayoub A, Reihani A, Padwal M, Imani J, Ayaub E, Yousof T, Dvorkin-Gheva A, Rullo A, Hirota JA, Richards CD, Bridgewater D, Stämpfli MR, Hambly N, [...] Ask K
Immunol Cell Biol, 101(5):412-427, 04 Apr 2023
Cited by: 1 article | PMID: 36862017
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Serum proteomic profiling of rheumatoid arthritis-interstitial lung disease with a comparison to idiopathic pulmonary fibrosis.
Wu X, Jeong Y, Poli de Frías S, Easthausen I, Hoffman K, Oromendia C, Taheri S, Esposito AJ, Quesada Arias L, Ayaub EA, Maurer R, Gill RR, Hatabu H, Nishino M, Frits ML, Iannaccone CK, Weinblatt ME, Shadick NA, Dellaripa PF, [...] Doyle TJ
Thorax, 77(10):1041-1044, 30 Jul 2022
Cited by: 6 articles | PMID: 35907639 | PMCID: PMC9976796
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Characterization of the COPD alveolar niche using single-cell RNA sequencing.
Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, [...] Rosas IO
Nat Commun, 13(1):494, 25 Jan 2022
Cited by: 72 articles | PMID: 35078977 | PMCID: PMC8789871
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Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection.
Lee AJ, Feng E, Chew MV, Balint E, Poznanski SM, Giles E, Zhang A, Marzok A, Revill SD, Vahedi F, Dubey A, Ayaub E, Jimenez-Saiz R, McGrath JJC, Ritchie TM, Jordana M, Jonigk DD, Ackermann M, Ask K, [...] Ashkar AA
PLoS Pathog, 18(5):e1010471, 05 May 2022
Cited by: 4 articles | PMID: 35512020 | PMCID: PMC9113601
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Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation.
Han J, Shi Y, Willis G, Imani J, Kwon MY, Li G, Ayaub E, Ghanta S, Ng J, Hwang N, Tsoyi K, El-Chemaly S, Kourembanas S, Mitsialis SA, Rosas IO, Liu X, Perrella MA
FEBS J, 289(2):417-435, 15 Aug 2021
Cited by: 11 articles | PMID: 34355516 | PMCID: PMC8766882
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Cell-Specific Transcriptome of the COPD Alveolar Niche
Sauler M, McDonough J, Adams T, Kotahpalli N, Schupp J, Barnthaler T, Robertson M, Coarfa CC, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub E, Chu S, Jensen K, Timshel P, Gomez J, Britto C, [...] Rosas I
Research Square, 11 Mar 2021
Cited by: 0 articles | PPR: PPR296267
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FK506-Binding Protein 13 Expression Is Upregulated in Interstitial Lung Disease and Correlated with Clinical Severity. A Potentially Protective Role.
Tat V, Ayaub EA, Ayoub A, Vierhout M, Naiel S, Padwal MK, Abed S, Mekhael O, Tandon K, Revill SD, Yousof T, Bellaye PS, Kolb PS, Dvorkin-Gheva A, Naqvi A, Cutz JC, Hambly N, Kato J, Vaughan M, [...] Ask K
Am J Respir Cell Mol Biol, 64(2):235-246, 01 Feb 2021
Cited by: 7 articles | PMID: 33253593 | PMCID: PMC8017597
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Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis
Ayaub E, Poli S, Ng J, Adams T, Schupp J, Quesada-Arias L, Poli F, Cosme C, Robertson M, Martinez-Manzano J, Liang X, Villalba J, Lederer J, Chu S, Raby B, Washko G, Coarfa C, Perrella M, El-Chemaly S, [...] Rosas I
bioRxiv, 05 Jan 2021
Cited by: 0 articles | PPR: PPR261903
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IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M.
Botelho F, Dubey A, Ayaub EA, Park R, Yip A, Humbles A, Kolbeck R, Richards CD
Mediators Inflamm, 2020:4087315, 28 Nov 2020
Cited by: 10 articles | PMID: 33376451 | PMCID: PMC7744230
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Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models.
Hettiarachchi SU, Li YH, Roy J, Zhang F, Puchulu-Campanella E, Lindeman SD, Srinivasarao M, Tsoyi K, Liang X, Ayaub EA, Nickerson-Nutter C, Rosas IO, Low PS
Sci Transl Med, 12(567):eaay3724, 01 Oct 2020
Cited by: 38 articles | PMID: 33115948
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Single-cell RNA sequencing identifies aberrant transcriptional profiles of cellular populations and altered alveolar niche signalling networks in Chronic Obstructive Pulmonary Disease (COPD)
Sauler M, McDonough J, Adams T, Kothapalli N, Schupp J, Nouws J, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub E, Chu S, Jensen K, Gomez-Villalobos J, Britto C, Raredon M, Timshel P, Kaminski N, Rosas I
medRxiv, 14 Sep 2020
Cited by: 0 articles | PPR: PPR213725
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The importance of interventional timing in the bleomycin model of pulmonary fibrosis.
Kolb P, Upagupta C, Vierhout M, Ayaub E, Bellaye PS, Gauldie J, Shimbori C, Inman M, Ask K, Kolb MRJ
Eur Respir J, 55(6):1901105, 11 Jun 2020
Cited by: 62 articles | PMID: 32165401
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Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis.
Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N
Sci Adv, 6(28):eaba1983, 08 Jul 2020
Cited by: 567 articles | PMID: 32832599 | PMCID: PMC7439502
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Reprogramming of profibrotic macrophages for treatment of bleomycin-induced pulmonary fibrosis.
Zhang F, Ayaub EA, Wang B, Puchulu-Campanella E, Li YH, Hettiarachchi SU, Lindeman SD, Luo Q, Rout S, Srinivasarao M, Cox A, Tsoyi K, Nickerson-Nutter C, Rosas IO, Low PS
EMBO Mol Med, 12(8):e12034, 29 Jun 2020
Cited by: 39 articles | PMID: 32597014 | PMCID: PMC7411553
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Palmitic Acid-Rich High-Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress.
Chu SG, Villalba JA, Liang X, Xiong K, Tsoyi K, Ith B, Ayaub EA, Tatituri RV, Byers DE, Hsu FF, El-Chemaly S, Kim EY, Shi Y, Rosas IO
Am J Respir Cell Mol Biol, 61(6):737-746, 01 Dec 2019
Cited by: 50 articles | PMID: 31461627 | PMCID: PMC6890409
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FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity: a potentially protective role
Tat V, Ayaub E, Ayoub A, Vierhout M, Naiel S, Padwal M, Abed S, Mekhael O, Tandon K, Revill S, Yousof T, Bellaye P, Kolb P, Dvorkin-Gheva A, Naqvi A, Cutz J, Hambly N, Kato J, Vaughan M, [...] Ask K
bioRxiv, 15 Dec 2019
Cited by: 0 articles | PPR: PPR105380
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Single Cell RNA-seq reveals ectopic and aberrant lung resident cell populations in Idiopathic Pulmonary Fibrosis
Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N
bioRxiv, 06 Sep 2019
Cited by: 3 articles | PPR: PPR91357
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Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy.
Van Krieken R, Mehta N, Wang T, Zheng M, Li R, Gao B, Ayaub E, Ask K, Paton JC, Paton AW, Austin RC, Krepinsky JC
J Biol Chem, 294(19):7755-7768, 26 Mar 2019
Cited by: 23 articles | PMID: 30914477 | PMCID: PMC6514638
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Mechanical stress-induced mast cell degranulation activates TGF-β1 signalling pathway in pulmonary fibrosis.
Shimbori C, Upagupta C, Bellaye PS, Ayaub EA, Sato S, Yanagihara T, Zhou Q, Ognjanovic A, Ask K, Gauldie J, Forsythe P, Kolb MRJ
Thorax, 74(5):455-465, 26 Feb 2019
Cited by: 42 articles | PMID: 30808717
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IL-6 mediates ER expansion during hyperpolarization of alternatively activated macrophages.
Ayaub EA, Tandon K, Padwal M, Imani J, Patel H, Dubey A, Mekhael O, Upagupta C, Ayoub A, Dvorkin-Gheva A, Murphy J, Kolb PS, Lhotak S, Dickhout JG, Austin RC, Kolb MRJ, Richards CD, Ask K
Immunol Cell Biol, 97(2):203-217, 14 Nov 2018
Cited by: 10 articles | PMID: 30298952 | PMCID: PMC7379543
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Separate roles of IL-6 and oncostatin M in mouse macrophage polarization in vitro and in vivo.
Dubey A, Izakelian L, Ayaub EA, Ho L, Stephenson K, Wong S, Kwofie K, Austin RC, Botelho F, Ask K, Richards CD
Immunol Cell Biol, 96(3):257-272, 26 Dec 2017
Cited by: 16 articles | PMID: 29363180
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Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis.
Ayaub EA, Dubey A, Imani J, Botelho F, Kolb MRJ, Richards CD, Ask K
Sci Rep, 7(1):13281, 16 Oct 2017
Cited by: 47 articles | PMID: 29038604 | PMCID: PMC5643520
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GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis.
Ayaub EA, Kolb PS, Mohammed-Ali Z, Tat V, Murphy J, Bellaye PS, Shimbori C, Boivin FJ, Lai R, Lynn EG, Lhoták Š, Bridgewater D, Kolb MR, Inman MD, Dickhout JG, Austin RC, Ask K
J Pathol, 239(4):411-425, 07 Jun 2016
Cited by: 69 articles | PMID: 27135434
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Disruption of Calcium Signaling in Fibroblasts and Attenuation of Bleomycin-Induced Fibrosis by Nifedipine.
Mukherjee S, Ayaub EA, Murphy J, Lu C, Kolb M, Ask K, Janssen LJ
Am J Respir Cell Mol Biol, 53(4):450-458, 01 Oct 2015
Cited by: 33 articles | PMID: 25664495
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