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Search life-sciences literature (45,103,589 articles, preprints and more)

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Population pharmacokinetic modelling of cetirizine concentrations in human breast milk-A contribution from the ConcePTION project.
Melander E, Nielsen EI, Lindqvist A, Hovd M, Gandia P, Panchaud A, Guidi M, Annaert P, Baranczewski P, Spigset O, Nordeng H
Basic Clin Pharmacol Toxicol, 04 Nov 2024
Cited by: 0 articles | PMID: 39497323
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AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1.
Díaz-Holguín A, Saarinen M, Vo DD, Sturchio A, Branzell N, Cabeza de Vaca I, Hu H, Mitjavila-Domènech N, Lindqvist A, Baranczewski P, Millan MJ, Yang Y, Carlsson J, Svenningsson P
Sci Adv, 10(32):eadn1524, 07 Aug 2024
Cited by: 0 articles | PMID: 39110804 | PMCID: PMC11305387
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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Huseby DL, Cao S, Zamaratski E, Sooriyaarachchi S, Ahmad S, Bergfors T, Krasnova L, Pelss J, Ikaunieks M, Loza E, Katkevics M, Bobileva O, Cirule H, Gukalova B, Grinberga S, Backlund M, Simoff I, Leber AT, Berruga-Fernández T, [...] Karlén A
Proc Natl Acad Sci U S A, 121(15):e2317274121, 05 Apr 2024
Cited by: 2 articles | PMID: 38579010 | PMCID: PMC11009625
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Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project.
Nordeng H, Wegler C, Lindqvist A, Melander E, Magnusson M, Gandia P, Panchaud A, Baranczewski P, Spigset O
Basic Clin Pharmacol Toxicol, 134(1):153-164, 13 Nov 2023
Cited by: 0 articles | PMID: 37811726
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Simple and rapid quantification of cetirizine, venlafaxine, and O-desmethylvenlafaxine in human breast milk, and metformin in human milk and plasma with UHPLC-MS/MS.
Wegler C, Saleh A, Lindqvist A, Nordeng H, Smeraglia J, Baranczewski P
J Chromatogr B Analyt Technol Biomed Life Sci, 1205:123340, 16 Jun 2022
Cited by: 1 article | PMID: 35732105
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Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt Adrian J, Calvopiña K, Turrientes MC, Kavanagh ME, Lubriks D, [...] Schofield CJ
Nat Chem, 14(1):15-24, 13 Dec 2021
Cited by: 23 articles | PMID: 34903857
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ENABLE: an engine for European antibacterial drug discovery and development.
Olliver M, Griestop L, Hughes D, Belfrage AK, Gising J, Baranczewski P, Vingsbo Lundberg C, Karlén A
Nat Rev Drug Discov, 20(6):407-408, 01 Jun 2021
Cited by: 4 articles | PMID: 33948003
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A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research.
Matsson P, Baranczewski P, Giacomini KM, Andersson TB, Palm J, Palm K, Charman WN, Bergström CAS
J Pharm Sci, 110(1):2-11, 21 Oct 2020
Cited by: 0 articles | PMID: 33096136
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Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Page BDG, Valerie NCK, Wright RHG, Wallner O, Isaksson R, Carter M, Rudd SG, Loseva O, Jemth AS, Almlöf I, Font-Mateu J, Llona-Minguez S, Baranczewski P, Jeppsson F, Homan E, Almqvist H, Axelsson H, Regmi S, Gustavsson AL, [...] Helleday T
Nat Commun, 10(1):5050, 01 Nov 2019
Cited by: 2 articles | PMID: 31676755 | PMCID: PMC6825185
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Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations.
Filppula AM, Parvizi R, Mateus A, Baranczewski P, Artursson P
Sci Rep, 9(1):5850, 10 Apr 2019
Cited by: 6 articles | PMID: 30971754 | PMCID: PMC6458156
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Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Visnes T, Cázares-Körner A, Hao W, Wallner O, Masuyer G, Loseva O, Mortusewicz O, Wiita E, Sarno A, Manoilov A, Astorga-Wells J, Jemth AS, Pan L, Sanjiv K, Karsten S, Gokturk C, Grube M, Homan EJ, Hanna BMF, [...] Helleday T
Science, 362(6416):834-839, 01 Nov 2018
Cited by: 105 articles | PMID: 30442810 | PMCID: PMC6645780
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Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound.
Islam MK, Strand M, Saleeb M, Svensson R, Baranczewski P, Artursson P, Wadell G, Ahlm C, Elofsson M, Evander M
Sci Rep, 8(1):1925, 31 Jan 2018
Cited by: 10 articles | PMID: 29386590 | PMCID: PMC5792431
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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Page BDG, Valerie NCK, Wright RHG, Wallner O, Isaksson R, Carter M, Rudd SG, Loseva O, Jemth AS, Almlöf I, Font-Mateu J, Llona-Minguez S, Baranczewski P, Jeppsson F, Homan E, Almqvist H, Axelsson H, Regmi S, Gustavsson AL, [...] Helleday T
Nat Commun, 9(1):250, 17 Jan 2018
Cited by: 31 articles | PMID: 29343827 | PMCID: PMC5772648
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Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
Llona-Minguez S, Höglund A, Ghassemian A, Desroses M, Calderón-Montaño JM, Burgos Morón E, Valerie NCK, Wiita E, Almlöf I, Koolmeister T, Mateus A, Cazares-Körner C, Sanjiv K, Homan E, Loseva O, Baranczewski P, Darabi M, Mehdizadeh A, Fayezi S, [...] Helleday T
J Med Chem, 60(17):7614, 01 Sep 2017
Cited by: 0 articles | PMID: 28862438
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Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
Llona-Minguez S, Höglund A, Ghassemian A, Desroses M, Calderón-Montaño JM, Burgos Morón E, Valerie NCK, Wiita E, Almlöf I, Koolmeister T, Mateus A, Cazares-Körner C, Sanjiv K, Homan E, Loseva O, Baranczewski P, Darabi M, Mehdizadeh A, Fayezi S, [...] Helleday T
J Med Chem, 60(10):4279-4292, 16 May 2017
Cited by: 7 articles | PMID: 28508636
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Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines.
Llona-Minguez S, Ghassemian A, Baranczewski P, Desroses M, Koolmeister T, Artursson P, Scobie M, Helleday T
Medchemcomm, 8(7):1553-1560, 04 Jul 2017
Cited by: 1 article | PMID: 30108867 | PMCID: PMC6072423
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Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, [...] Ulrika Warpman Berglund &Thomas Helleday
Nature, 544(7651):508, 01 Apr 2017
Cited by: 4 articles | PMID: 28447629
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Validation and development of MTH1 inhibitors for treatment of cancer.
Warpman Berglund U, Sanjiv K, Gad H, Kalderén C, Koolmeister T, Pham T, Gokturk C, Jafari R, Maddalo G, Seashore-Ludlow B, Chernobrovkin A, Manoilov A, Pateras IS, Rasti A, Jemth AS, Almlöf I, Loseva O, Visnes T, Einarsdottir BO, [...] Helleday T
Ann Oncol, 27(12):2275-2283, 08 Nov 2016
Cited by: 67 articles | PMID: 27827301
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Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.
Llona-Minguez S, Höglund A, Wiita E, Almlöf I, Mateus A, Calderón-Montaño JM, Cazares-Körner C, Homan E, Loseva O, Baranczewski P, Jemth AS, Häggblad M, Martens U, Lundgren B, Artursson P, Lundbäck T, Jenmalm Jensen A, Warpman Berglund U, Scobie M, Helleday T
J Med Chem, 60(5):2148-2154, 15 Feb 2017
Cited by: 8 articles | PMID: 28145708
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Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
Llona-Minguez S, Höglund A, Jacques SA, Johansson L, Calderón-Montaño JM, Claesson M, Loseva O, Valerie NCK, Lundbäck T, Piedrafita J, Maga G, Crespan E, Meijer L, Morón EB, Baranczewski P, Hagbjörk AL, Svensson R, Wiita E, Almlöf I, [...] Helleday T
J Med Chem, 59(3):1140-1148, 27 Jan 2016
Cited by: 19 articles | PMID: 26771665 | PMCID: PMC4753678
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Optimizing DMPK Properties: Experiences from a Big Pharma DMPK Department.
Sohlenius-Sternbeck AK, Janson J, Bylund J, Baranczewski P, Breitholtz-Emanuelsson A, Hu Y, Tsoi C, Lindgren A, Gissberg O, Bueters T, Briem S, Juric S, Johansson J, Bergh M, Hoogstraate J
Curr Drug Metab, 17(3):253-270, 01 Jan 2016
Cited by: 4 articles | PMID: 26651977
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, [...] Helleday T
Nature, 508(7495):215-221, 02 Apr 2014
Cited by: 275 articles | PMID: 24695224
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Assessment of interaction potential of AZD2066 using in vitro metabolism tools, physiologically based pharmacokinetic modelling and in vivo cocktail data.
Nordmark A, Andersson A, Baranczewski P, Wanag E, Ståhle L
Eur J Clin Pharmacol, 70(2):167-178, 02 Nov 2013
Cited by: 11 articles | PMID: 24186263
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Effect of solvents on the time-dependent inhibition of CYP3A4 and the biotransformation of AZD3839 in human liver microsomes and hepatocytes.
Aasa J, Hu Y, Eklund G, Lindgren A, Baranczewski P, Malmquist J, Turek D, Bueters T
Drug Metab Dispos, 41(1):159-169, 16 Oct 2012
Cited by: 5 articles | PMID: 23073735
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Characterization of niflumic acid as a selective inhibitor of human liver microsomal UDP-glucuronosyltransferase 1A9: application to the reaction phenotyping of acetaminophen glucuronidation.
Miners JO, Bowalgaha K, Elliot DJ, Baranczewski P, Knights KM
Drug Metab Dispos, 39(4):644-652, 18 Jan 2011
Cited by: 62 articles | PMID: 21245288
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