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Search life-sciences literature (45,105,671 articles, preprints and more)

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The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, Ludwig A
J Immunol, 172(10):6362-6372, 01 May 2004
Cited by: 278 articles | PMID: 15128827
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CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.
Berkhout TA, Blaney FE, Bridges AM, Cooper DG, Forbes IT, Gribble AD, Groot PH, Hardy A, Ife RJ, Kaur R, Moores KE, Shillito H, Willetts J, Witherington J
J Med Chem, 46(19):4070-4086, 01 Sep 2003
Cited by: 46 articles | PMID: 12954060
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The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A
Blood, 102(4):1186-1195, 24 Apr 2003
Cited by: 470 articles | PMID: 12714508
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CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound.
Forbes IT, Cooper DG, Dodds EK, Hickey DM, Ife RJ, Meeson M, Stockley M, Berkhout TA, Gohil J, Groot PH, Moores K
Bioorg Med Chem Lett, 10(16):1803-1806, 01 Aug 2000
Cited by: 35 articles | PMID: 10969972
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The role of fractalkine in the recruitment of monocytes to the endothelium.
Chapman GA, Moores KE, Gohil J, Berkhout TA, Patel L, Green P, Macphee CH, Stewart BR
Eur J Pharmacol, 392(3):189-195, 01 Mar 2000
Cited by: 57 articles | PMID: 10762673
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Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1).
Berkhout TA, Gohil J, Gonzalez P, Nicols CL, Moores KE, Macphee CH, White JR, Groot PH
Biochem Pharmacol, 59(5):591-596, 01 Mar 2000
Cited by: 7 articles | PMID: 10660125
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The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076.
Pearce NJ, Yates JW, Berkhout TA, Jackson B, Tew D, Boyd H, Camilleri P, Sweeney P, Gribble AD, Shaw A, Groot PH
Biochem J, 334 ( Pt 1):113-119, 01 Aug 1998
Cited by: 77 articles | PMID: 9693110 | PMCID: PMC1219669
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Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B.
Berkhout TA, Sarau HM, Moores K, White JR, Elshourbagy N, Appelbaum E, Reape RJ, Brawner M, Makwana J, Foley JJ, Schmidt DB, Imburgia C, McNulty D, Matthews J, O'Donnell K, O'Shannessy D, Scott M, Groot PH, Macphee C
J Biol Chem, 272(26):16404-16413, 01 Jun 1997
Cited by: 50 articles | PMID: 9195948
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SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis.
Berkhout TA, Simon HM, Jackson B, Yates J, Pearce N, Groot PH, Bentzen C, Niesor E, Kerns WD, Suckling KE
Atherosclerosis, 133(2):203-212, 01 Sep 1997
Cited by: 12 articles | PMID: 9298680
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Induction of cytochrome P4503A by the antiglucocorticoid mifepristone and a novel hypocholesterolaemic drug.
Williams JA, Chenery RJ, Berkhout TA, Hawksworth GM
Drug Metab Dispos, 25(6):757-761, 01 Jun 1997
Cited by: 9 articles | PMID: 9193879
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The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Berkhout TA, Simon HM, Patel DD, Bentzen C, Niesor E, Jackson B, Suckling KE
J Biol Chem, 271(24):14376-14382, 01 Jun 1996
Cited by: 22 articles | PMID: 8662919
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Separation of immunomodulatory and cholesterol-lowering activities of heterocyclic azaspiranes.
Albrightson CR, Bugelski PJ, Berkhout TA, Jackson B, Kerns WD, Organ AJ, Badger AM
J Pharmacol Exp Ther, 272(2):689-698, 01 Feb 1995
Cited by: 4 articles | PMID: 7853183
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Effects of a novel lanosterol 14 alpha-demethylase inhibitor on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hep G2 cells.
Mayer RJ, Adams JL, Bossard MJ, Berkhout TA
J Biol Chem, 266(30):20070-20078, 01 Oct 1991
Cited by: 16 articles | PMID: 1657912
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The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2.
Berkhout TA, Havekes LM, Pearce NJ, Groot PH
Biochem J, 272(1):181-186, 01 Nov 1990
Cited by: 32 articles | PMID: 2176080 | PMCID: PMC1149674
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Preferential lipid association and mode of penetration of apocytochrome c in mixed model membranes as monitored by tryptophanyl fluorescence quenching using brominated phospholipids.
Berkhout TA, Rietveld A, de Kruijff B
Biochim Biophys Acta, 897(1):1-4, 01 Feb 1987
Cited by: 21 articles | PMID: 3026475
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Coupling of photoactivatable glycolipid probes to apolipoproteins A-I and A-II in human high density lipoproteins 2 and 3.
Berkhout TA, Groot PH, van Belzen R, Wirtz KW
J Lipid Res, 26(8):964-969, 01 Aug 1985
Cited by: 1 article | PMID: 3930643
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Preferential association of apocytochrome c with negatively charged phospholipids in mixed model membranes.
Rietveld A, Berkhout TA, Roenhorst A, Marsh D, de Kruijff B
Biochim Biophys Acta, 858(1):38-46, 01 Jun 1986
Cited by: 15 articles | PMID: 3011094
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Identification of membrane proteins of human blood platelets with a hydrophobic photolabel.
Berkhout TA, Schiphorst ME, Wirtz KW, Sixma JJ
Biochim Biophys Acta, 778(2):298-304, 01 Dec 1984
Cited by: 2 articles | PMID: 6498194
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The lipid binding site of the phosphatidylcholine transfer protein from bovine liver.
van Loon D, Berkhout TA, Demel RA, Wirtz KW
Chem Phys Lipids, 38(1-2):29-39, 01 Aug 1985
Cited by: 3 articles | PMID: 4064223
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Static and time-resolved fluorescence studies of fluorescent phosphatidylcholine bound to the phosphatidylcholine transfer protein of bovine liver.
Berkhout TA, Visser AJ, Wirtz KW
Biochemistry, 23(7):1505-1513, 01 Mar 1984
Cited by: 11 articles | PMID: 6722104
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Labeling of phospholipids in vesicles and human erythrocytes by photoactivable fatty acid derivatives.
Berkhout TA, van Amerongen A, Wirtz KW
Eur J Biochem, 142(1):91-97, 01 Jul 1984
Cited by: 5 articles | PMID: 6745269
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Analysis of histones from the yeast Saccharomyces carlsbergensis.
Pastink A, Berkhout TA, Mager WH, Planta RJ
Biochem J, 177(3):917-923, 01 Mar 1979
Cited by: 7 articles | PMID: 220954 | PMCID: PMC1186458
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