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Search life-sciences literature (45,104,145 articles, preprints and more)

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Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
Konteatis Z, Travins J, Gross S, Marjon K, Barnett A, Mandley E, Nicolay B, Nagaraja R, Chen Y, Sun Y, Liu Z, Yu J, Ye Z, Jiang F, Wei W, Fang C, Gao Y, Kalev P, Hyer ML, [...] Marks KM
J Med Chem, 64(8):4430-4449, 08 Apr 2021
Cited by: 23 articles | PMID: 33829783
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An allosteric mechanism for potent inhibition of human ATP-citrate lyase.
Wei J, Leit S, Kuai J, Therrien E, Rafi S, Harwood HJ, DeLaBarre B, Tong L
Nature, 568(7753):566-570, 03 Apr 2019
Cited by: 61 articles | PMID: 30944472
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AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.
Kung C, Hixon J, Kosinski PA, Cianchetta G, Histen G, Chen Y, Hill C, Gross S, Si Y, Johnson K, DeLaBarre B, Luo Z, Gu Z, Yao G, Tang H, Fang C, Xu Y, Lv X, Biller S, [...] Dang L
Blood, 130(11):1347-1356, 31 Jul 2017
Cited by: 43 articles | PMID: 28760888 | PMCID: PMC5609468
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AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
Yen K, Travins J, Wang F, David MD, Artin E, Straley K, Padyana A, Gross S, DeLaBarre B, Tobin E, Chen Y, Nagaraja R, Choe S, Jin L, Konteatis Z, Cianchetta G, Saunders JO, Salituro FG, Quivoron C, [...] Su SM
Cancer Discov, 7(5):478-493, 13 Feb 2017
Cited by: 239 articles | PMID: 28193778
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Action at a distance: allostery and the development of drugs to target cancer cell metabolism.
DeLaBarre B, Hurov J, Cianchetta G, Murray S, Dang L
Chem Biol, 21(9):1143-1161, 01 Sep 2014
Cited by: 26 articles | PMID: 25237859
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Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.
Ulanet DB, Couto K, Jha A, Choe S, Wang A, Woo HK, Steadman M, DeLaBarre B, Gross S, Driggers E, Dorsch M, Hurov JB
PLoS One, 9(12):e115144, 12 Dec 2014
Cited by: 26 articles | PMID: 25502225 | PMCID: PMC4264947
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.
Davis MI, Gross S, Shen M, Straley KS, Pragani R, Lea WA, Popovici-Muller J, DeLaBarre B, Artin E, Thorne N, Auld DS, Li Z, Dang L, Boxer MB, Simeonov A
J Biol Chem, 289(20):13717-13725, 25 Mar 2014
Cited by: 50 articles | PMID: 24668804 | PMCID: PMC4022846
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Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition
Ulanet D, Jha A, Couto K, Choe S, Wang A, Woo H, Steadman M, DeLaBarre B, Gross S, Driggers E, Dorsch M, Hurov J
Cancer Metab, 2(suppl 1):P78-P78, 01 Jan 2014
Cited by: 0 articles | PMCID: PMC4072977
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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.
Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E, Straley K, Kernytsky A, Liu W, Gliser C, Yang H, Gross S, Artin E, Saada V, Mylonas E, Quivoron C, Popovici-Muller J, Saunders JO, Salituro FG, [...] Yen KE
Science, 340(6132):622-626, 04 Apr 2013
Cited by: 521 articles | PMID: 23558173
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Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.
Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, DeLaBarre B, Cianchetta G, Sethumadhavan S, Wang X, Yan S, Gao Y, Fang C, Wei W, Jiang F, Wang S, Qian K, Saunders J, Driggers E, [...] Dang L
Chem Biol, 19(9):1187-1198, 01 Sep 2012
Cited by: 103 articles | PMID: 22999886 | PMCID: PMC3775715
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Full-length human glutaminase in complex with an allosteric inhibitor.
DeLaBarre B, Gross S, Fang C, Gao Y, Jha A, Jiang F, Song J J, Wei W, Hurov JB
Biochemistry, 50(50):10764-10770, 18 Nov 2011
Cited by: 91 articles | PMID: 22049910
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X-ray structure determination at low resolution.
Brunger AT, DeLaBarre B, Davies JM, Weis WI
Acta Crystallogr D Biol Crystallogr, 65(pt 2):128-133, 20 Jan 2009
Cited by: 27 articles | PMID: 19171967 | PMCID: PMC2631637
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Crystal structure of a hyperactive Escherichia coli glycerol kinase mutant Gly230 --> Asp obtained using microfluidic crystallization devices.
Anderson MJ, DeLabarre B, Raghunathan A, Palsson BO, Brunger AT, Quake SR
Biochemistry, 46(19):5722-5731, 19 Apr 2007
Cited by: 15 articles | PMID: 17441732
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Considerations for the refinement of low-resolution crystal structures.
DeLaBarre B, Brunger AT
Acta Crystallogr D Biol Crystallogr, 62(pt 8):923-932, 18 Jul 2006
Cited by: 43 articles | PMID: 16855310
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Central pore residues mediate the p97/VCP activity required for ERAD.
DeLaBarre B, Christianson JC, Kopito RR, Brunger AT
Mol Cell, 22(4):451-462, 01 May 2006
Cited by: 160 articles | PMID: 16713576
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Nucleotide dependent motion and mechanism of action of p97/VCP.
DeLaBarre B, Brunger AT
J Mol Biol, 347(2):437-452, 01 Mar 2005
Cited by: 120 articles | PMID: 15740751
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Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains.
DeLaBarre B, Brunger AT
Nat Struct Biol, 10(10):856-863, 31 Aug 2003
Cited by: 252 articles | PMID: 12949490
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Dimerization of recombinant tobacco mosaic virus movement protein.
Brill LM, Dechongkit S, DeLaBarre B, Stroebel J, Beachy RN, Yeager M
J Virol, 78(7):3372-3377, 01 Apr 2004
Cited by: 20 articles | PMID: 15016859 | PMCID: PMC371043
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NSF and p97/VCP: similar at first, different at last.
Brunger AT, DeLaBarre B
FEBS Lett, 555(1):126-133, 01 Nov 2003
Cited by: 59 articles | PMID: 14630332
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Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle.
Rouiller I, DeLaBarre B, May AP, Weis WI, Brunger AT, Milligan RA, Wilson-Kubalek EM
Nat Struct Biol, 9(12):950-957, 01 Dec 2002
Cited by: 143 articles | PMID: 12434150
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Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases.
DeLaBarre B, Thompson PR, Wright GD, Berghuis AM
Nat Struct Biol, 7(3):238-244, 01 Mar 2000
Cited by: 27 articles | PMID: 10700284
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Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae.
DeLaBarre B, Jacques SL, Pratt CE, Ruth DA, Wright GD, Berghuis AM
Acta Crystallogr D Biol Crystallogr, 54(pt 3):413-415, 01 May 1998
Cited by: 1 article | PMID: 9761913
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1-22 of 22 results

Search life-sciences literature (45,104,145 articles, preprints and more)

Search results

Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.

An allosteric mechanism for potent inhibition of human ATP-citrate lyase.

AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.

Action at a distance: allostery and the development of drugs to target cancer cell metabolism.

Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.

Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.

Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.

Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.

Full-length human glutaminase in complex with an allosteric inhibitor.

X-ray structure determination at low resolution.

Crystal structure of a hyperactive Escherichia coli glycerol kinase mutant Gly230 --> Asp obtained using microfluidic crystallization devices.

Considerations for the refinement of low-resolution crystal structures.

Central pore residues mediate the p97/VCP activity required for ERAD.

Nucleotide dependent motion and mechanism of action of p97/VCP.

Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains.

Dimerization of recombinant tobacco mosaic virus movement protein.

NSF and p97/VCP: similar at first, different at last.

Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle.

Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases.

Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae.

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