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Therapeutic potential of the latest oxygen affinity-modifying agent, GBT021601, for treating sickle cell disease is questionable.
Alaimo B, Metaferia B, Cellmer T, Thein SL, Bunn HF, Eaton WA
Br J Haematol, 06 Nov 2024
Cited by: 0 articles | PMID: 39503354
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Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease.
D'Alessandro A, Le K, Lundt M, Li Q, Dunkelberger EB, Cellmer T, Worth AJ, Patil S, Huston C, Grier A, Dzieciatkowska M, Stephenson D, Eaton WA, Thein SL
Haematologica, 109(8):2639-2652, 01 Aug 2024
Cited by: 2 articles | PMID: 38450513
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In vivo measurement of RBC survival in patients with sickle cell disease before or after hematopoietic stem cell transplantation.
Leonard AK, Furstenau D, Inam Z, Luckett C, Chu R, Demirci S, Essawi K, Gudmundsdottir B, Hinds M, DiNicola J, Li Q, Eaton WA, Cellmer T, Wang X, Thein SL, Macari ER, VanNest S, Hsieh MM, Bonner M, [...] Tisdale JF
Blood Adv, 8(7):1806-1816, 01 Apr 2024
Cited by: 1 article | PMID: 38181784 | PMCID: PMC11006808
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Recent developments in the use of pyruvate kinase activators as a new approach for treating sickle cell disease.
Parekh DS, Eaton WA, Thein SL
Blood, 143(10):866-871, 01 Mar 2024
Cited by: 2 articles | PMID: 38118071
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Drug discovery by a basic research scientist.
Eaton WA
Front Mol Biosci, 9:1062346, 03 Nov 2022
Cited by: 0 articles | PMID: 36406264 | PMCID: PMC9669753
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A retrospective on statistical mechanical models for hemoglobin allostery.
Eaton WA
J Chem Phys, 157(18):184104, 01 Nov 2022
Cited by: 6 articles | PMID: 36379793 | PMCID: PMC9830738
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A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease.
Xu JZ, Conrey A, Frey I, Gwaabe E, Menapace LA, Tumburu L, Lundt M, Lequang T, Li Q, Glass K, Dunkelberger EB, Iyer V, Mangus H, Kung C, Dang L, Kosinski PA, Hawkins P, Jeffries N, Eaton WA, Lay Thein S
Blood, 140(19):2053-2062, 01 Nov 2022
Cited by: 21 articles | PMID: 35576529 | PMCID: PMC9837441
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Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease.
Metaferia B, Cellmer T, Dunkelberger EB, Li Q, Henry ER, Hofrichter J, Staton D, Hsieh MM, Conrey AK, Tisdale JF, Chatterjee AK, Thein SL, Eaton WA
Proc Natl Acad Sci U S A, 119(40):e2210779119, 26 Sep 2022
Cited by: 10 articles | PMID: 36161945 | PMCID: PMC9546543
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Phenotypic screening of the ReFrame Drug Repurposing Library to discover new drugs for treating sickle cell disease
Metaferia B, Cellmer T, Dunkelberger EB, Li Q, Henry ER, Hofrichter J, Staton D, Hsieh MM, Conrey AK, Tisdale JF, Chatterjee AK, Thein SL, Eaton WA
bioRxiv, 26 Jun 2022
Cited by: 0 articles | PPR: PPR511045
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Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model.
Quezado ZMN, Kamimura S, Smith M, Wang X, Heaven MR, Jana S, Vogel S, Zerfas P, Combs CA, Almeida LEF, Li Q, Quezado M, Horkayne-Szakaly I, Kosinski PA, Yu S, Kapadnis U, Kung C, Dang L, Wakim P, [...] Thein SL
Blood Cells Mol Dis, 95:102660, 12 Mar 2022
Cited by: 8 articles | PMID: 35366607 | PMCID: PMC9148618
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Impact of Conformational Substates and Energy Landscapes on Understanding Hemoglobin Kinetics and Function.
Eaton WA
J Biol Phys, 47(4):337-353, 11 Nov 2021
Cited by: 3 articles | PMID: 34762226 | PMCID: PMC8603986
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Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin.
Henry ER, Metaferia B, Li Q, Harper J, Best RB, Glass KE, Cellmer T, Dunkelberger EB, Conrey A, Thein SL, Bunn HF, Eaton WA
Blood, 138(13):1172-1181, 01 Sep 2021
Cited by: 27 articles | PMID: 34197597 | PMCID: PMC8570057
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Impact of hemoglobin biophysical studies on molecular pathogenesis and drug therapy for sickle cell disease.
Eaton WA
Mol Aspects Med, 84:100971, 14 Jul 2021
Cited by: 8 articles | PMID: 34274158 | PMCID: PMC8758802
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MWC allosteric model explains unusual hemoglobin-oxygen binding curves from sickle cell drug binding.
Henry ER, Harper J, Glass KE, Metaferia B, Louis JM, Eaton WA
Biophys J, 120(12):2543-2551, 29 Apr 2021
Cited by: 10 articles | PMID: 33932439 | PMCID: PMC8390878
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Modern Kinetics and Mechanism of Protein Folding: A Retrospective.
Eaton WA
J Phys Chem B, 125(14):3452-3467, 16 Mar 2021
Cited by: 13 articles | PMID: 33724035 | PMCID: PMC8054241
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Estimating computational limits on theoretical descriptions of biological cells.
Netz RR, Eaton WA
Proc Natl Acad Sci U S A, 118(6):e2022753118, 01 Feb 2021
Cited by: 6 articles | PMID: 33495364 | PMCID: PMC8017709
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Physics of virus transmission by speaking droplets.
Netz RR, Eaton WA
Proc Natl Acad Sci U S A, 117(41):25209-25211, 24 Sep 2020
Cited by: 27 articles | PMID: 32973098 | PMCID: PMC7568337
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Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.
Henry ER, Cellmer T, Dunkelberger EB, Metaferia B, Hofrichter J, Li Q, Ostrowski D, Ghirlando R, Louis JM, Moutereau S, Galactéros F, Thein SL, Bartolucci P, Eaton WA
Proc Natl Acad Sci U S A, 117(26):15018-15027, 11 Jun 2020
Cited by: 21 articles | PMID: 32527859 | PMCID: PMC7334536
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Physics of Virus Transmission by Speaking Droplets
Eaton WA, Bax A, Netz RR
medRxiv, 16 May 2020
Cited by: 0 articles | PPR: PPR163710
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Treating sickle cell anemia.
Tisdale JF, Thein SL, Eaton WA
Science, 367(6483):1198-1199, 01 Mar 2020
Cited by: 29 articles | PMID: 32165573 | PMCID: PMC7299198
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Hemoglobin S polymerization and sickle cell disease: A retrospective on the occasion of the 70th anniversary of Pauling's Science paper.
Eaton WA
Am J Hematol, 95(2):205-211, 31 Dec 2019
Cited by: 19 articles | PMID: 31763707 | PMCID: PMC7003899
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Interactions of an Anti-Sickling Drug with Hemoglobin in Red Blood Cells from a Patient with Sickle Cell Anemia.
Strader MB, Liang H, Meng F, Harper J, Ostrowski DA, Henry ER, Shet AS, Eaton WA, Thein SL, Alayash AI
Bioconjug Chem, 30(3):568-571, 28 Feb 2019
Cited by: 7 articles | PMID: 30794381 | PMCID: PMC9148702
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Autobiography of William A. Eaton.
Eaton WA
J Phys Chem B, 122(49):10974-10980, 01 Dec 2018
Cited by: 2 articles | PMID: 30986083
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Voxelotor treatment of a patient with sickle cell disease and very severe anemia.
Shet AS, Mendelsohn L, Harper J, Ostrowski D, Henry ER, Gwaabe E, Nichols J, Alayash AI, Eaton WA, Thein SL
Am J Hematol, 94(4):E88-E90, 08 Jan 2019
Cited by: 3 articles | PMID: 30592074 | PMCID: PMC6408257
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Publications of William A. Eaton.
Eaton WA
J Phys Chem B, 122(49):10983-10988, 01 Dec 2018
Cited by: 0 articles | PMID: 30986082
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