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Search life-sciences literature (45,105,671 articles, preprints and more)

Suggested authors matching "AUTH:Erbel P" with an ORCID

Paulus Erbel
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Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition.
Dekker C, Mattes H, Wright M, Boettcher A, Hinniger A, Hughes N, Kapps-Fouthier S, Eder J, Erbel P, Stiefl N, Mackay A, Farady CJ
J Mol Biol, 433(24):167309, 20 Oct 2021
Cited by: 50 articles | PMID: 34687713
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Pharmacological inhibition of IKKβ dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1.
Unterreiner A, Rubert J, Kauffmann M, Fruhauf A, Heiser D, Erbel P, Schlapbach A, Eder J, Bodendorf U, Boettcher A, Farady CJ, Bornancin F
Biochem Biophys Res Commun, 545:177-182, 06 Feb 2021
Cited by: 9 articles | PMID: 33561652
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Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.
Pissot Soldermann C, Simic O, Renatus M, Erbel P, Melkko S, Wartmann M, Bigaud M, Weiss A, McSheehy P, Endres R, Santos P, Blank J, Schuffenhauer A, Bold G, Buschmann N, Zoller T, Altmann E, Manley PW, Dix I, [...] Régnier CH
J Med Chem, 63(23):14576-14593, 30 Nov 2020
Cited by: 4 articles | PMID: 33252239
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Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.
Quancard J, Simic O, Pissot Soldermann C, Aichholz R, Blatter M, Renatus M, Erbel P, Melkko S, Endres R, Sorge M, Kieffer L, Wagner T, Beltz K, Mcsheehy P, Wartmann M, Régnier CH, Calzascia T, Radimerski T, Bigaud M, [...] Schlapbach A
J Med Chem, 63(23):14594-14608, 20 Nov 2020
Cited by: 5 articles | PMID: 33216547
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Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
Mainolfi N, Ehara T, Karki RG, Anderson K, Mac Sweeney A, Liao SM, Argikar UA, Jendza K, Zhang C, Powers J, Klosowski DW, Crowley M, Kawanami T, Ding J, April M, Forster C, Serrano-Wu M, Capparelli M, Ramqaj R, [...] Adams CM
J Med Chem, 63(11):5697-5722, 19 Feb 2020
Cited by: 16 articles | PMID: 32073845
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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Schubart A, Anderson K, Mainolfi N, Sellner H, Ehara T, Adams CM, Mac Sweeney A, Liao SM, Crowley M, Littlewood-Evans A, Sarret S, Wieczorek G, Perrot L, Dubost V, Flandre T, Zhang Y, Smith RJH, Risitano AM, Karki RG, [...] Eder J
Proc Natl Acad Sci U S A, 116(16):7926-7931, 29 Mar 2019
Cited by: 86 articles | PMID: 30926668 | PMCID: PMC6475383
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.
Quancard J, Klein T, Fung SY, Renatus M, Hughes N, Israël L, Priatel JJ, Kang S, Blank MA, Viner RI, Blank J, Schlapbach A, Erbel P, Kizhakkedathu J, Villard F, Hersperger R, Turvey SE, Eder J, Bornancin F, Overall CM
Nat Chem Biol, 15(3):304-313, 28 Jan 2019
Cited by: 24 articles | PMID: 30692685
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N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.
Schlapbach A, Revesz L, Pissot Soldermann C, Zoller T, Régnier CH, Bornancin F, Radimerski T, Blank J, Schuffenhauer A, Renatus M, Erbel P, Melkko S, Heng R, Simic O, Endres R, Wartmann M, Quancard J
Bioorg Med Chem Lett, 28(12):2153-2158, 09 May 2018
Cited by: 7 articles | PMID: 29759726
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Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.
Vulpetti A, Ostermann N, Randl S, Yoon T, Mac Sweeney A, Cumin F, Lorthiois E, Rüdisser S, Erbel P, Maibaum J
ACS Med Chem Lett, 9(5):490-495, 24 Apr 2018
Cited by: 2 articles | PMID: 29795765 | PMCID: PMC5949727
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Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.
Altmann E, Erbel P, Renatus M, Schaefer M, Schlierf A, Druet A, Kieffer L, Sorge M, Pfister K, Hassiepen U, Jones M, Ruedisser S, Ostermeier D, Martoglio B, Jefferson AB, Quancard J
Angew Chem Int Ed Engl, 56(5):1294-1297, 16 Dec 2016
Cited by: 15 articles | PMID: 27981705
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Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.
Vulpetti A, Randl S, Rüdisser S, Ostermann N, Erbel P, Mac Sweeney A, Zoller T, Salem B, Gerhartz B, Cumin F, Hommel U, Dalvit C, Lorthiois E, Maibaum J
J Med Chem, 60(5):1946-1958, 20 Feb 2017
Cited by: 5 articles | PMID: 28157311
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Small-molecule factor D inhibitors targeting the alternative complement pathway.
Maibaum J, Liao SM, Vulpetti A, Ostermann N, Randl S, Rüdisser S, Lorthiois E, Erbel P, Kinzel B, Kolb FA, Barbieri S, Wagner J, Durand C, Fettis K, Dussauge S, Hughes N, Delgado O, Hommel U, Gould T, [...] Anderson K
Nat Chem Biol, 12(12):1105-1110, 24 Oct 2016
Cited by: 37 articles | PMID: 27775713
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Structure-based design and optimization of potent inhibitors of the adenoviral protease.
Grosche P, Sirockin F, Mac Sweeney A, Ramage P, Erbel P, Melkko S, Bernardi A, Hughes N, Ellis D, Combrink KD, Jarousse N, Altmann E
Bioorg Med Chem Lett, 25(3):438-443, 24 Dec 2014
Cited by: 12 articles | PMID: 25571794
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Discovery and structure-based optimization of adenain inhibitors.
Mac Sweeney A, Grosche P, Ellis D, Combrink K, Erbel P, Hughes N, Sirockin F, Melkko S, Bernardi A, Ramage P, Jarousse N, Altmann E
ACS Med Chem Lett, 5(8):937-941, 20 Jun 2014
Cited by: 9 articles | PMID: 25147618 | PMCID: PMC4137446
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Structural determinants of MALT1 protease activity.
Wiesmann C, Leder L, Blank J, Bernardi A, Melkko S, Decock A, D'Arcy A, Villard F, Erbel P, Hughes N, Freuler F, Nikolay R, Alves J, Bornancin F, Renatus M
J Mol Biol, 419(1-2):4-21, 23 Feb 2012
Cited by: 43 articles | PMID: 22366302
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Fragment-based screening by biochemical assays: Systematic feasibility studies with trypsin and MMP12.
Boettcher A, Ruedisser S, Erbel P, Vinzenz D, Schiering N, Hassiepen U, Rigollier P, Mayr LM, Woelcke J
J Biomol Screen, 15(9):1029-1041, 20 Sep 2010
Cited by: 18 articles | PMID: 20855559
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Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.
Mac Sweeney A, Gil-Parrado S, Vinzenz D, Bernardi A, Hein A, Bodendorf U, Erbel P, Logel C, Gerhartz B
J Mol Biol, 384(1):228-239, 19 Sep 2008
Cited by: 30 articles | PMID: 18824173
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Mechanism of substrate specificity in Bacillus subtilis ResA, a thioredoxin-like protein involved in cytochrome c maturation.
Colbert CL, Wu Q, Erbel PJ, Gardner KH, Deisenhofer J
Proc Natl Acad Sci U S A, 103(12):4410-4415, 13 Mar 2006
Cited by: 26 articles | PMID: 16537372 | PMCID: PMC1400588
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Purification and crystallization of dengue and West Nile virus NS2B-NS3 complexes.
D'Arcy A, Chaillet M, Schiering N, Villard F, Lim SP, Lefeuvre P, Erbel P
Acta Crystallogr Sect F Struct Biol Cryst Commun, 62(pt 2):157-162, 27 Jan 2006
Cited by: 9 articles | PMID: 16511290 | PMCID: PMC2150946
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Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U
Nat Struct Mol Biol, 13(4):372-373, 12 Mar 2006
Cited by: 291 articles | PMID: 16532006
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Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor.
Yang J, Zhang L, Erbel PJ, Gardner KH, Ding K, Garcia JA, Bruick RK
J Biol Chem, 280(43):36047-36054, 29 Aug 2005
Cited by: 48 articles | PMID: 16129688
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Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.
Card PB, Erbel PJ, Gardner KH
J Mol Biol, 353(3):664-677, 06 Sep 2005
Cited by: 90 articles | PMID: 16181639
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Identification and Biosynthesis of Cyclic Enterobacterial Common Antigen in Escherichia coli
Erbel P, Barr K, Gao N, Gerwig G, Rick P, Gardner K
J Bacteriol, 186(4):1220-1220, 01 Feb 2004
Cited by: 0 articles | PMCID: PMC387291
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Cyclic enterobacterial common antigen: potential contaminant of bacterially expressed protein preparations.
Erbel PJ, Seidel R, Macintosh SE, Gentile LN, Amor JC, Kahn RA, Prestegard JH, McIntosh LP, Gardner KH
J Biomol NMR, 29(2):199-204, 01 Jun 2004
Cited by: 8 articles | PMID: 15014233
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Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.
Erbel PJ, Card PB, Karakuzu O, Bruick RK, Gardner KH
Proc Natl Acad Sci U S A, 100(26):15504-15509, 10 Dec 2003
Cited by: 139 articles | PMID: 14668441 | PMCID: PMC307597
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Search life-sciences literature (45,105,671 articles, preprints and more)

Suggested authors matching "AUTH:Erbel P" with an ORCID

Search results

Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition.

Pharmacological inhibition of IKKβ dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1.

Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.

Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.

Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.

N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.

Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.

Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.

Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.

Small-molecule factor D inhibitors targeting the alternative complement pathway.

Structure-based design and optimization of potent inhibitors of the adenoviral protease.

Discovery and structure-based optimization of adenain inhibitors.

Structural determinants of MALT1 protease activity.

Fragment-based screening by biochemical assays: Systematic feasibility studies with trypsin and MMP12.

Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.

Mechanism of substrate specificity in Bacillus subtilis ResA, a thioredoxin-like protein involved in cytochrome c maturation.

Purification and crystallization of dengue and West Nile virus NS2B-NS3 complexes.

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor.

Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.

Identification and Biosynthesis of Cyclic Enterobacterial Common Antigen in Escherichia coli

Cyclic enterobacterial common antigen: potential contaminant of bacterially expressed protein preparations.

Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.

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Suggested authors matching "AUTH:Erbel P" with an ORCID