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Search life-sciences literature (45,103,589 articles, preprints and more)

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Angiopoietin-2 reverses endothelial cell dysfunction in progeria vasculature.
Vakili S, Izydore EK, Losert L, Cabral WA, Tavarez UL, Shores K, Xue H, Erdos MR, Truskey GA, Collins FS, Cao K
Aging Cell, e14375, 18 Oct 2024
Cited by: 0 articles | PMID: 39422121
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Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h.
Grenko CM, Taylor HJ, Bonnycastle LL, Xue D, Lee BN, Weiss Z, Yan T, Swift AJ, Mansell EC, Lee A, Robertson CC, Narisu N, Erdos MR, Chen S, Collins FS, Taylor DL
Diabetologia, 67(10):2246-2259, 05 Jul 2024
Cited by: 0 articles | PMID: 38967666 | PMCID: PMC11447040
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Scalable Hypothalamic Arcuate Neuron Differentiation from Human Pluripotent Stem Cells Suitable for Modeling Metabolic and Reproductive Disorders
Jovanovic VM, Narisu N, Bonnycastle LL, Tharakan R, Mesch KT, Glover HJ, Yan T, Sinha N, Sen C, Castellano D, Yang S, Blivis D, Ryu S, Bennett DF, Rosales-Soto G, Inman J, Ormanoglu P, LeClair CA, Xia M, [...] Tristan CA
bioRxiv, 02 Jul 2024
Cited by: 0 articles | PPR: PPR875568
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Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing.
Bonnycastle LL, Swift AJ, Mansell EC, Lee A, Winnicki E, Li ES, Robertson CC, Parsons VA, Huynh T, Krilow C, Mohlke KL, Erdos MR, Narisu N, Collins FS
CRISPR J, 7(1):53-67, 01 Feb 2024
Cited by: 0 articles | PMID: 38353623 | PMCID: PMC10880268
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Population-scale skeletal muscle single-nucleus multi-omic profiling reveals extensive context specific genetic regulation
Varshney A, Manickam N, Orchard P, Tovar A, Zhang Z, Feng F, Erdos MR, Narisu N, Ventresca C, Nishino K, Rai V, Stringham HM, Jackson AU, Tamsen T, Gao C, Yang M, Koues OI, Welch JD, Burant CF, [...] Parker SCJ
bioRxiv, 15 Dec 2023
Cited by: 0 articles | PPR: PPR774129
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Detecting Protein-DNA Binding in Single Molecules using Antibody Guided Methylation
Thatavarty A, Sagy N, Erdos MR, Lee I, Simpson JT, Timp W, Collins FS, Bar DZ
bioRxiv, 20 Nov 2023
Cited by: 0 articles | PPR: PPR762576
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Adipose tissue eQTL meta-analysis reveals the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits
Brotman SM, El-Sayed Moustafa JS, Guan L, Broadaway KA, Wang D, Jackson AU, Welch R, Currin KW, Tomlinson M, Vadlamudi S, Stringham HM, Roberts AL, Lakka TA, Oravilahti A, Silva LF, Narisu N, Erdos MR, Yan T, Bonnycastle LL, [...] Scott LJ
bioRxiv, 27 Oct 2023
Cited by: 0 articles | PPR: PPR748629
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Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells.
Xue D, Narisu N, Taylor DL, Zhang M, Grenko C, Taylor HJ, Yan T, Tang X, Sinha N, Zhu J, Vandana JJ, Nok Chong AC, Lee A, Mansell EC, Swift AJ, Erdos MR, Zhong A, Bonnycastle LL, Zhou T, [...] Collins FS
Cell Metab, 35(11):1897-1914.e11, 18 Oct 2023
Cited by: 7 articles | PMID: 37858332 | PMCID: PMC10841752
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Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits.
Hudaiberdiev S, Taylor DL, Song W, Narisu N, Bhuiyan RM, Taylor HJ, Tang X, Yan T, Swift AJ, Bonnycastle LL, Consortium D, Chen S, Stitzel ML, Erdos MR, Ovcharenko I, Collins FS
Proc Natl Acad Sci U S A, 120(35):e2206612120, 21 Aug 2023
Cited by: 4 articles | PMID: 37603758 | PMCID: PMC10469333
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Bone dysplasia in Hutchinson-Gilford progeria syndrome is associated with dysregulated differentiation and function of bone cell populations.
Cabral WA, Stephan C, Terajima M, Thaivalappil AA, Blanchard O, Tavarez UL, Narisu N, Yan T, Wincovitch SM, Taga Y, Yamauchi M, Kozloff KM, Erdos MR, Collins FS
Aging Cell, 22(9):e13903, 26 Jun 2023
Cited by: 3 articles | PMID: 37365004 | PMCID: PMC10497813
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Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 hours
Grenko CM, Bonnycastle LL, Taylor HJ, Yan T, Swift AJ, Robertson CC, Narisu N, Erdos MR, Collins FS, Taylor DL
bioRxiv, 08 Jun 2023
Cited by: 0 articles | PPR: PPR672743
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Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.
Williamson A, Norris DM, Yin X, Broadaway KA, Moxley AH, Vadlamudi S, Wilson EP, Jackson AU, Ahuja V, Andersen MK, Arzumanyan Z, Bonnycastle LL, Bornstein SR, Bretschneider MP, Buchanan TA, Chang YC, Chuang LM, Chung RH, Clausen TD, [...] Langenberg C
Nat Genet, 55(6):973-983, 08 Jun 2023
Cited by: 11 articles | PMID: 37291194 | PMCID: PMC7614755
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Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells
Xue D, Narisu N, Taylor DL, Zhang M, Grenko C, Taylor HJ, Yan T, Tang X, Sinha N, Zhu J, Vandana JJ, Chong ACN, Lee A, Mansell EC, Swift AJ, Erdos MR, Zhou T, Bonnycastle LL, Zhong A, [...] Collins FS
bioRxiv, 08 May 2023
Cited by: 0 articles | PPR: PPR656412
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Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis.
Taylor HJ, Hung YH, Narisu N, Erdos MR, Kanke M, Yan T, Grenko CM, Swift AJ, Bonnycastle LL, Sethupathy P, Collins FS, Taylor DL
Proc Natl Acad Sci U S A, 120(7):e2206797120, 09 Feb 2023
Cited by: 8 articles | PMID: 36757889 | PMCID: PMC9963967
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Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk.
Yin X, Bose D, Kwon A, Hanks SC, Jackson AU, Stringham HM, Welch R, Oravilahti A, Fernandes Silva L, FinnGen, Locke AE, Fuchsberger C, Service SK, Erdos MR, Bonnycastle LL, Kuusisto J, Stitziel NO, Hall IM, Morrison J, [...] Wen X
Am J Hum Genet, 109(10):1727-1741, 01 Sep 2022
Cited by: 13 articles | PMID: 36055244 | PMCID: PMC9606383
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ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19.
El-Sayed Moustafa JS, Jackson AU, Brotman SM, Guan L, Villicaña S, Roberts AL, Zito A, Bonnycastle L, Erdos MR, Narisu N, Stringham HM, Welch R, Yan T, Lakka T, Parker S, Tuomilehto J, Seow J, Graham C, Huettner I, [...] Small KS
Int J Obes (Lond), 46(8):1478-1486, 20 May 2022
Cited by: 25 articles | PMID: 35589964 | PMCID: PMC9119844
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Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis
Taylor HJ, Hung Y, Narisu N, Erdos MR, Kanke M, Yan T, Grenko CM, Swift AJ, Bonnycastle LL, Sethupathy P, Collins FS, Taylor DL
bioRxiv, 21 Apr 2022
Cited by: 0 articles | PPR: PPR493786
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Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits
Hudaiberdiev S, Taylor DL, Song W, Narisu N, Bhuiyan RM, Taylor HJ, Yan T, Swift AJ, Bonnycastle LL, DIAMANTE Consortium, Stitzel ML, Erdos MR, Ovcharenko I, Collins FS
medRxiv, 16 May 2022
Cited by: 0 articles | PPR: PPR496225
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Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.
Yin X, Chan LS, Bose D, Jackson AU, VandeHaar P, Locke AE, Fuchsberger C, Stringham HM, Welch R, Yu K, Fernandes Silva L, Service SK, Zhang D, Hector EC, Young E, Ganel L, Das I, Abel H, Erdos MR, [...] Boehnke M
Nat Commun, 13(1):1644, 28 Mar 2022
Cited by: 61 articles | PMID: 35347128 | PMCID: PMC8960770
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Genome-wide association study of 1,391 plasma metabolites in 6,136 Finnish men identifies 303 novel signals and provides biological insights into human diseases
Yin X, Chan LS, Bose D, Jackson AU, VandeHaar P, Locke AE, Fuchsberger C, Stringham HM, Yu K, Silva LF, Service SK, Zhang D, Hector EC, Young E, Ganel L, Das I, Abel H, Erdos MR, Bonnycastle LL, [...] Boehnke M
medRxiv, 20 Oct 2021
Cited by: 0 articles | PPR: PPR438916
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Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson-Gilford Progeria syndrome.
Cabral WA, Tavarez UL, Beeram I, Yeritsyan D, Boku YD, Eckhaus MA, Nazarian A, Erdos MR, Collins FS
Aging Cell, 20(9):e13457, 28 Aug 2021
Cited by: 22 articles | PMID: 34453483 | PMCID: PMC8441492
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Base editor treats progeria in mice.
Koblan LW, Erdos MR, Gordon LB, Collins FS, Brown JD, Liu DR
Nature, 18 Jun 2021
Cited by: 4 articles | PMID: 34285403
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SARS-CoV-2 infection induces beta cell transdifferentiation.
Tang X, Uhl S, Zhang T, Xue D, Li B, Vandana JJ, Acklin JA, Bonnycastle LL, Narisu N, Erdos MR, Bram Y, Chandar V, Chong ACN, Lacko LA, Min Z, Lim JK, Borczuk AC, Xiang J, Naji A, [...] Chen S
Cell Metab, 33(8):1577-1591.e7, 19 May 2021
Cited by: 103 articles | PMID: 34081913 | PMCID: PMC8133495
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Genetic effects on liver chromatin accessibility identify disease regulatory variants.
Currin KW, Erdos MR, Narisu N, Rai V, Vadlamudi S, Perrin HJ, Idol JR, Yan T, Albanus RD, Broadaway KA, Etheridge AS, Bonnycastle LL, Orchard P, Didion JP, Chaudhry AS, NISC Comparative Sequencing Program, Innocenti F, Schuetz EG, Scott LJ, [...] Mohlke KL
Am J Hum Genet, 108(7):1169-1189, 25 May 2021
Cited by: 21 articles | PMID: 34038741 | PMCID: PMC8323023
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A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures.
Varshney A, Kyono Y, Elangovan VR, Wang C, Erdos MR, Narisu N, Albanus RD, Orchard P, Stitzel ML, Collins FS, Kitzman JO, Parker SCJ
Diabetes, 70(7):1581-1591, 13 Apr 2021
Cited by: 6 articles | PMID: 33849996 | PMCID: PMC8336006
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