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Harnessing gene therapy for liver metabolic dysfunction: An innovative approach to MASH treatment.
Unzu C, Fernández-Barrena MG
Mol Ther, S1525-0016(24)00729-9, 15 Nov 2024
Cited by: 0 articles | PMID: 39549705
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Non-mitogenic FGF19 mRNA-based therapy for the treatment of experimental metabolic dysfunction-associated steatotic liver disease (MASLD).
Lopez-Pascual A, Russo-Cabrera JS, Ardaiz N, Palmer T, Graham AR, Uriarte I, Gomar C, Ruiz-Guillamon D, Latasa MU, Arechederra M, Fontanellas A, Monte MJ, Marin JJG, Berasain C, Del Rio CL, Fernandez-Barrena MG, Martini PGV, Schultz JR, Berraondo P, Avila MA
Clin Sci (Lond), 138(20):1265-1284, 01 Oct 2024
Cited by: 0 articles | PMID: 39301694
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Comprehensive in silico CpG methylation analysis in hepatocellular carcinoma identifies tissue- and tumor-type specific marks disconnected from gene expression.
Bilbao I, Recalde M, Daian F, Herranz JM, Elizalde M, Iñarrairaegui M, Canale M, Fernández-Barrena MG, Casadei-Gardini A, Sangro B, Ávila MA, Landecho Acha MF, Berasain C, Arechederra M
J Physiol Biochem, 21 Sep 2024
Cited by: 0 articles | PMID: 39305372
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KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis.
Sigafoos AN, Tolosa EJ, Carr RM, Fernandez-Barrena MG, Almada LL, Pease DR, Hogenson TL, Raja Arul GL, Mousavi F, Sen S, Vera RE, Marks DL, Flores LF, LaRue-Nolan KC, Wu C, Bamlet WR, Vrabel AM, Sicotte H, Schenk EL, [...] Fernandez-Zapico ME
Cancer Res Commun, 4(7):1677-1689, 01 Jul 2024
Cited by: 0 articles | PMID: 38896052 | PMCID: PMC11232480
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Sweet dreams could be made of this: carbohydrate-responsive element-binding protein (ChREBP) as a target for hepatocellular carcinoma therapy.
Fernández-Barrena MG, Avila MA
Mol Oncol, 18(9):2107-2110, 04 Jun 2024
Cited by: 0 articles | PMID: 38837736 | PMCID: PMC11467787
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Caspases compromise SLU7 and UPF1 stability and NMD activity during hepatocarcinogenesis.
Rojo C, Gárate-Rascón M, Recalde M, Álava A, Elizalde M, Azkona M, Aldabe I, Guruceaga E, López-Pascual A, Latasa MU, Sangro B, Fernández-Barrena MG, Ávila MA, Arechederra M, Berasain C
JHEP Rep, 6(8):101118, 09 May 2024
Cited by: 0 articles | PMID: 39105183 | PMCID: PMC11298840
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Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH).
Alvarado-Tapias E, Maya-Miles D, Albillos A, Aller R, Ampuero J, Andrade RJ, Arechederra M, Aspichueta P, Banales JM, Blas-García A, Caparros E, Cardoso Delgado T, Carrillo-Vico A, Claria J, Cubero FJ, Díaz-Ruiz A, Fernández-Barrena MG, Fernández-Iglesias A, Fernández-Veledo S, [...] Gahete MD
Gastroenterol Hepatol, S0210-5705(24)00165-1, 08 May 2024
Cited by: 0 articles | PMID: 38723772
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New insights into the regulation of bile acids synthesis during the early stages of liver regeneration: A human and experimental study.
Uriarte I, Santamaria E, López-Pascual A, Monte MJ, Argemí J, Latasa MU, Adán-Villaescusa E, Irigaray A, Herranz JM, Arechederra M, Basualdo J, Lucena F, Corrales FJ, Rotellar F, Pardo F, Merlen G, Rainteau D, Sangro B, Tordjmann T, [...] Avila MA
Biochim Biophys Acta Mol Basis Dis, 1870(5):167166, 19 Apr 2024
Cited by: 0 articles | PMID: 38642480
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Frontiers in fatty liver: recent advances in pathogenic mechanisms, assessment of patients' prognosis and pharmacotherapy : MASLD: new pathogenic mechanisms, risk assessment tools and drug therapies.
Fernández-Barrena MG, Avila MA
J Physiol Biochem, 79(4):811-813, 21 Oct 2023
Cited by: 0 articles | PMID: 37864126
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A new FGF15/19-mediated gut-to-heart axis controls cardiac hypertrophy.
Morón-Ros S, Blasco-Roset A, Navarro-Gascon A, Rupérez C, Zamora M, Crispi F, Uriarte I, Fernández-Barrena MG, Avila M, Ferrer-Curriu G, Lupón J, Bayés-Genis A, Villarroya F, Gavaldà-Navarro A, Planavila A
J Pathol, 261(3):335-348, 31 Aug 2023
Cited by: 0 articles | PMID: 37650293
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Comprehensive analysis of epigenetic and epitranscriptomic genes' expression in human NAFLD.
Herranz JM, López-Pascual A, Clavería-Cabello A, Uriarte I, Latasa MU, Irigaray-Miramon A, Adán-Villaescusa E, Castelló-Uribe B, Sangro B, Arechederra M, Berasain C, Avila MA, Fernández-Barrena MG
J Physiol Biochem, 79(4):901-924, 25 Aug 2023
Cited by: 4 articles | PMID: 37620598 | PMCID: PMC10636027
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Identification and experimental validation of druggable epigenetic targets in hepatoblastoma.
Clavería-Cabello A, Herranz JM, Latasa MU, Arechederra M, Uriarte I, Pineda-Lucena A, Prosper F, Berraondo P, Alonso C, Sangro B, García Marin JJ, Martinez-Chantar ML, Ciordia S, Corrales FJ, Francalanci P, Alaggio R, Zucman-Rossi J, Indersie E, Cairo S, [...] Avila MA
J Hepatol, 79(4):989-1005, 10 Jun 2023
Cited by: 11 articles | PMID: 37302584
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Mapping early serum proteome signatures of liver regeneration in living donor liver transplant cases.
Carmona-Rodríguez L, Gajadhar AS, Blázquez-García I, Guerrero L, Fernández-Rojo MA, Uriarte I, Mamani-Huanca M, López-Gonzálvez Á, Ciordia S, Ramos A, Herrero JI, Fernández-Barrena MG, Arechederra M, Berasain C, Quiroga J, Sangro B, Argemi J, Pardo F, Rotellar F, [...] Corrales FJ
Biofactors, 49(4):912-927, 12 May 2023
Cited by: 1 article | PMID: 37171157
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Loss of liver function in chronic liver disease: An identity crisis.
Berasain C, Arechederra M, Argemí J, Fernández-Barrena MG, Avila MA
J Hepatol, 78(2):401-414, 15 Sep 2022
Cited by: 23 articles | PMID: 36115636
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SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease.
Gárate-Rascón M, Recalde M, Rojo C, Fernández-Barrena MG, Ávila MA, Arechederra M, Berasain C
Int J Mol Sci, 23(21):13411, 02 Nov 2022
Cited by: 3 articles | PMID: 36362191 | PMCID: PMC9658179
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Hepatic progenitor cells, senescence and IL-6 as the main players in combined hepatocellular-cholangiocarcinoma development.
Arechederra M, Fernández-Barrena MG
J Hepatol, 77(6):1479-1481, 21 Sep 2022
Cited by: 1 article | PMID: 36150576
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New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming.
Colyn L, Alvarez-Sola G, Latasa MU, Uriarte I, Herranz JM, Arechederra M, Vlachogiannis G, Rae C, Pineda-Lucena A, Casadei-Gardini A, Pedica F, Aldrighetti L, López-López A, López-Gonzálvez A, Barbas C, Ciordia S, Van Liempd SM, Falcón-Pérez JM, Urman J, [...] Avila MA
J Exp Clin Cancer Res, 41(1):183, 26 May 2022
Cited by: 6 articles | PMID: 35619118 | PMCID: PMC9134609
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Metabolic-associated fatty liver disease: From simple steatosis toward liver cirrhosis and potential complications. Proceedings of the Third Translational Hepatology Meeting, organized by the Spanish Association for the Study of the Liver (AEEH).
Gallego-Durán R, Albillos A, Ampuero J, Arechederra M, Bañares R, Blas-García A, Berná G, Caparrós E, Delgado TC, Falcón-Pérez JM, Francés R, Fernández-Barrena MG, Graupera I, Iruzubieta P, Nevzorova YA, Nogueiras R, Macías RIR, Martín F, Sabio G, [...] Gracia-Sancho J
Gastroenterol Hepatol, 45(9):724-734, 03 Mar 2022
Cited by: 5 articles | PMID: 35248669
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DNA Methylation Regulates a Set of Long Non-Coding RNAs Compromising Hepatic Identity during Hepatocarcinogenesis.
Recalde M, Gárate-Rascón M, Herranz JM, Elizalde M, Azkona M, Unfried JP, Boix L, Reig M, Sangro B, Fernández-Barrena MG, Fortes P, Ávila MA, Berasain C, Arechederra M
Cancers (Basel), 14(9):2048, 19 Apr 2022
Cited by: 6 articles | PMID: 35565178 | PMCID: PMC9102946
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Impact of CYLD on chromatin structure and histone methylation in malignant melanoma.
Schott M, Kappelmann-Fenzl M, Fischer S, Fernandez-Barrena MG, Pineda-Lucena A, Ávila MA, Kuphal S, Bosserhoff AK
Int J Mol Med, 49(5):66, 16 Mar 2022
Cited by: 3 articles | PMID: 35293595 | PMCID: PMC8973957
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Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models.
Olaizola P, Lee-Law PY, Fernandez-Barrena MG, Alvarez L, Cadamuro M, Azkargorta M, O'Rourke CJ, Caballero-Camino FJ, Olaizola I, Macias RIR, Marin JJG, Serrano-Maciá M, Martinez-Chantar ML, Avila MA, Aspichueta P, Calvisi DF, Evert M, Fabris L, Castro RE, [...] Banales JM
J Hepatol, 77(1):177-190, 23 Feb 2022
Cited by: 12 articles | PMID: 35217064
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Epigenetic remodelling in human hepatocellular carcinoma.
Braghini MR, Lo Re O, Romito I, Fernandez-Barrena MG, Barbaro B, Pomella S, Rota R, Vinciguerra M, Avila MA, Alisi A
J Exp Clin Cancer Res, 41(1):107, 24 Mar 2022
Cited by: 26 articles | PMID: 35331312 | PMCID: PMC8943959
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Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease.
Chen C, Wu H, Ye H, Tortajada A, Rodríguez-Perales S, Torres-Ruiz R, Vidal A, Peligros MI, Reissing J, Bruns T, Mohamed MR, Zheng K, Lujambio A, Iraburu MJ, Colyn L, Latasa MU, Arechederra M, Fernández-Barrena MG, Berasain C, [...] Cubero FJ
Cancers (Basel), 14(1):78, 24 Dec 2021
Cited by: 3 articles | PMID: 35008241 | PMCID: PMC8750579
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Correction: Current and novel therapeutic opportunities for systemic therapy in biliary cancer.
Marin JJG, Prete MG, Lamarca A, Tavolari S, Landa-Magdalena A, Brandi G, Segatto O, Vogel A, Macias RIR, Rodrigues PM, La Casta A, Mertens J, Rodrigues CMP, Fernandez-Barrena MG, Da Silva Ruivo A, Marzioni M, Mentrasti G, Acedo P, Munoz-Garrido P, [...] working group 6 of the COST-action 18122 (Euro-Cholangio-NET) as part of the European Network for the study of Cholangiocarcinoma (ENSCCA)
Br J Cancer, 125(6):904, 01 Sep 2021
Cited by: 1 article | PMID: 34226686 | PMCID: PMC8437953
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Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
Gárate-Rascón M, Recalde M, Jimenez M, Elizalde M, Azkona M, Uriarte I, Latasa MU, Urtasun R, Bilbao I, Sangro B, Garcia-Ruiz C, Fernandez-Checa JC, Corrales FJ, Esquivel A, Pineda-Lucena A, Fernández-Barrena MG, Ávila MA, Arechederra M, Berasain C
Hepatology, 74(5):2791-2807, 25 Sep 2021
Cited by: 9 articles | PMID: 34170569
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1-25 of 78 results

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Search life-sciences literature (45,100,050 articles, preprints and more)

Search results

Harnessing gene therapy for liver metabolic dysfunction: An innovative approach to MASH treatment.

Non-mitogenic FGF19 mRNA-based therapy for the treatment of experimental metabolic dysfunction-associated steatotic liver disease (MASLD).

Comprehensive in silico CpG methylation analysis in hepatocellular carcinoma identifies tissue- and tumor-type specific marks disconnected from gene expression.

KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis.

Sweet dreams could be made of this: carbohydrate-responsive element-binding protein (ChREBP) as a target for hepatocellular carcinoma therapy.

Caspases compromise SLU7 and UPF1 stability and NMD activity during hepatocarcinogenesis.

Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH).

New insights into the regulation of bile acids synthesis during the early stages of liver regeneration: A human and experimental study.

Frontiers in fatty liver: recent advances in pathogenic mechanisms, assessment of patients' prognosis and pharmacotherapy : MASLD: new pathogenic mechanisms, risk assessment tools and drug therapies.

A new FGF15/19-mediated gut-to-heart axis controls cardiac hypertrophy.

Comprehensive analysis of epigenetic and epitranscriptomic genes' expression in human NAFLD.

Identification and experimental validation of druggable epigenetic targets in hepatoblastoma.

Mapping early serum proteome signatures of liver regeneration in living donor liver transplant cases.

Loss of liver function in chronic liver disease: An identity crisis.

SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease.

Hepatic progenitor cells, senescence and IL-6 as the main players in combined hepatocellular-cholangiocarcinoma development.

New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming.

Metabolic-associated fatty liver disease: From simple steatosis toward liver cirrhosis and potential complications. Proceedings of the Third Translational Hepatology Meeting, organized by the Spanish Association for the Study of the Liver (AEEH).

DNA Methylation Regulates a Set of Long Non-Coding RNAs Compromising Hepatic Identity during Hepatocarcinogenesis.

Impact of CYLD on chromatin structure and histone methylation in malignant melanoma.

Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models.

Epigenetic remodelling in human hepatocellular carcinoma.

Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease.

Correction: Current and novel therapeutic opportunities for systemic therapy in biliary cancer.

Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.

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