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Search life-sciences literature (45,104,206 articles, preprints and more)

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CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation.
Chüeh AC, Advani G, Foroutan M, Smith J, Ng N, Nandurkar H, Lio DS, Zhu HJ, Chong YP, Verkade H, Fujita DJ, Bjorge J, Basheer F, Lim JP, Luk I, Dhillon A, Sakthianandeswaren A, Mouradov D, Sieber O, [...] Cheng HC
Oncogene, 40(17):3015-3029, 25 Mar 2021
Cited by: 12 articles | PMID: 33767439
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Delivery of gene targeting siRNAs to breast cancer cells using a multifunctional peptide complex that promotes both targeted delivery and endosomal release.
Bjorge JD, Pang A, Fujita DJ
PLoS One, 12(6):e0180578, 30 Jun 2017
Cited by: 10 articles | PMID: 28666009 | PMCID: PMC5493434
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A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.
Hossain MI, Roulston CL, Kamaruddin MA, Chu PWY, Ng DCH, Dusting GJ, Bjorge JD, Williamson NA, Fujita DJ, Cheung SN, Chan TO, Hill AF, Cheng HC
J Biol Chem, 288(14):9696-9709, 11 Feb 2013
Cited by: 28 articles | PMID: 23400779 | PMCID: PMC3617272
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Src regulates the activity of the ING1 tumor suppressor.
Yu L, Thakur S, Leong-Quong RY, Suzuki K, Pang A, Bjorge JD, Riabowol K, Fujita DJ
PLoS One, 8(4):e60943, 09 Apr 2013
Cited by: 18 articles | PMID: 23585863 | PMCID: PMC3621671
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SRC is dephosphorylated at tyrosine 530 in human colon carcinomas.
Zhu S, Bjorge JD, Fujita DJ
Chin J Cancer Res, 23(3):229-231, 01 Sep 2011
Cited by: 3 articles | PMID: 23467908 | PMCID: PMC3587553
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Inhibition of Lck: evidence for a novel natural Src family kinase inhibitor.
Zhu S, Fujita DJ, Wang JH
J Enzyme Inhib Med Chem, 27(4):546-552, 10 Aug 2011
Cited by: 0 articles | PMID: 21827365
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Simultaneous siRNA targeting of Src and downstream signaling molecules inhibit tumor formation and metastasis of a human model breast cancer cell line.
Bjorge JD, Pang AS, Funnell M, Chen KY, Diaz R, Magliocco AM, Fujita DJ
PLoS One, 6(4):e19309, 26 Apr 2011
Cited by: 31 articles | PMID: 21541295 | PMCID: PMC3082570
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REAP: A two minute cell fractionation method.
Suzuki K, Bose P, Leong-Quong RY, Fujita DJ, Riabowol K
BMC Res Notes, 3:294, 10 Nov 2010
Cited by: 299 articles | PMID: 21067583 | PMCID: PMC2993727
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The von Hippel-Lindau Tumor Suppressor Protein Is Destabilized by Src: Implications for Tumor Angiogenesis and Progression.
Chou MT, Anthony J, Bjorge JD, Fujita DJ
Genes Cancer, 1(3):225-238, 01 Mar 2010
Cited by: 22 articles | PMID: 21212839 | PMCID: PMC3014987
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Decreased CHK protein levels are associated with Src activation in colon cancer cells.
Zhu S, Bjorge JD, Cheng HC, Fujita DJ
Oncogene, 27(14):2027-2034, 15 Oct 2007
Cited by: 15 articles | PMID: 17934522
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PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation.
Zhu S, Bjorge JD, Fujita DJ
Cancer Res, 67(21):10129-10137, 01 Nov 2007
Cited by: 105 articles | PMID: 17974954
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C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.
Chong YP, Chan AS, Chan KC, Williamson NA, Lerner EC, Smithgall TE, Bjorge JD, Fujita DJ, Purcell AW, Scholz G, Mulhern TD, Cheng HC
J Biol Chem, 281(44):32988-32999, 07 Sep 2006
Cited by: 27 articles | PMID: 16959780
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SUMO modification of Sam68 enhances its ability to repress cyclin D1 expression and inhibits its ability to induce apoptosis.
Babic I, Cherry E, Fujita DJ
Oncogene, 25(36):4955-4964, 27 Mar 2006
Cited by: 53 articles | PMID: 16568089
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A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity.
Chong YP, Mulhern TD, Zhu HJ, Fujita DJ, Bjorge JD, Tantiongco JP, Sotirellis N, Lio DS, Scholz G, Cheng HC
J Biol Chem, 279(20):20752-20766, 25 Feb 2004
Cited by: 36 articles | PMID: 14985335
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The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity.
Babic I, Jakymiw A, Fujita DJ
Oncogene, 23(21):3781-3789, 01 May 2004
Cited by: 55 articles | PMID: 15021911
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Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells.
Chou MT, Wang J, Fujita DJ
BMC Biochem, 3:32, 31 Dec 2002
Cited by: 66 articles | PMID: 12509223 | PMCID: PMC140315
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Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines.
Bjorge JD, Pang A, Fujita DJ
J Biol Chem, 275(52):41439-41446, 01 Dec 2000
Cited by: 186 articles | PMID: 11007774
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Identification and characterization of a novel Golgi protein, golgin-67.
Jakymiw A, Raharjo E, Rattner JB, Eystathioy T, Chan EK, Fujita DJ
J Biol Chem, 275(6):4137-4144, 01 Feb 2000
Cited by: 30 articles | PMID: 10660574
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Selected glimpses into the activation and function of Src kinase.
Bjorge JD, Jakymiw A, Fujita DJ
Oncogene, 19(49):5620-5635, 01 Nov 2000
Cited by: 264 articles | PMID: 11114743
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cSrc is a major cytosolic tyrosine kinase in vascular tissue.
Oda Y, Renaux B, Bjorge J, Saifeddine M, Fujita DJ, Hollenberg MD
Can J Physiol Pharmacol, 77(8):606-617, 01 Aug 1999
Cited by: 60 articles | PMID: 10543724
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Activating SRC mutation in a subset of advanced human colon cancers.
Irby RB, Mao W, Coppola D, Kang J, Loubeau JM, Trudeau W, Karl R, Fujita DJ, Jove R, Yeatman TJ
Nat Genet, 21(2):187-190, 01 Feb 1999
Cited by: 299 articles | PMID: 9988270
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Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen.
Eystathioy T, Jakymiw A, Fujita DJ, Fritzler MJ, Chan EK
J Autoimmun, 14(2):179-187, 01 Mar 2000
Cited by: 20 articles | PMID: 10677249
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Common in vitro substrate specificity and differential Src homology 2 domain accessibility displayed by two members of the Src family of protein-tyrosine kinases, c-Src and Hck.
Sicilia RJ, Hibbs ML, Bello PA, Bjorge JD, Fujita DJ, Stanley IJ, Dunn AR, Cheng HC
J Biol Chem, 273(27):16756-16763, 01 Jul 1998
Cited by: 9 articles | PMID: 9642231
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Association of neurofilament proteins with neuronal Cdk5 activator.
Qi Z, Tang D, Zhu X, Fujita DJ, Wang JH
J Biol Chem, 273(4):2329-2335, 01 Jan 1998
Cited by: 24 articles | PMID: 9442078
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Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential.
Irby R, Mao W, Coppola D, Jove R, Gamero A, Cuthbertson D, Fujita DJ, Yeatman TJ
Cell Growth Differ, 8(12):1287-1295, 01 Dec 1997
Cited by: 22 articles | PMID: 9419417
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