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Reciprocal regulation of p21 and Chk1 controls the cyclin D1-RB pathway to mediate senescence onset after G2 arrest.
Lossaint G, Horvat A, Gire V, Bačević K, Mrouj K, Charrier-Savournin F, Georget V, Fisher D, Dulić V
J Cell Sci, 135(8):jcs259114, 28 Apr 2022
Cited by: 10 articles | PMID: 35343565
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Mechanisms and Regulation of Cellular Senescence.
Roger L, Tomas F, Gire V
Int J Mol Sci, 22(23):13173, 06 Dec 2021
Cited by: 96 articles | PMID: 34884978 | PMCID: PMC8658264
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Reciprocal regulation of p21 and Chk1 controls the Cyclin D1-RB pathway to mediate senescence onset after DNA damage-induced G2 arrest
Lossaint G, Horvat A, Gire V, Bacevic K, Mrouj K, Charrier-Savournin F, Georget V, Fisher D, Dulic V
bioRxiv, 17 Aug 2021
Cited by: 0 articles | PPR: PPR383906
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Greatwall promotes cell transformation by hyperactivating AKT in human malignancies.
Vera J, Lartigue L, Vigneron S, Gadea G, Gire V, Del Rio M, Soubeyran I, Chibon F, Lorca T, Castro A
Elife, 4:e10115, 27 Nov 2015
Cited by: 38 articles | PMID: 26613407 | PMCID: PMC4733044
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The p53 isoform Δ133p53β promotes cancer stem cell potential.
Arsic N, Gadea G, Lagerqvist EL, Busson M, Cahuzac N, Brock C, Hollande F, Gire V, Pannequin J, Roux P
Stem Cell Reports, 4(4):531-540, 05 Mar 2015
Cited by: 46 articles | PMID: 25754205 | PMCID: PMC4400643
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Senescence from G2 arrest, revisited.
Gire V, Dulic V
Cell Cycle, 14(3):297-304, 01 Jan 2015
Cited by: 139 articles | PMID: 25564883 | PMCID: PMC4353294
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Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response.
Jullien L, Mestre M, Roux P, Gire V
Nucleic Acids Res, 41(2):900-911, 27 Nov 2012
Cited by: 18 articles | PMID: 23193277 | PMCID: PMC3553962
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Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells.
Roger L, Jullien L, Gire V, Roux P
J Cell Sci, 123(pt 8):1295-1305, 23 Mar 2010
Cited by: 71 articles | PMID: 20332115
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[Senescence: a telomeric limit to immortality or a cellular response to physiologic stresses?].
Gire V
Med Sci (Paris), 21(5):491-497, 01 May 2005
Cited by: 7 articles | PMID: 15885198
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Dysfunctional telomeres at senescence signal cell cycle arrest via Chk2.
Gire V
Cell Cycle, 3(10):1217-1220, 13 Oct 2004
Cited by: 13 articles | PMID: 15467458
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p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress.
Charrier-Savournin FB, Château MT, Gire V, Sedivy J, Piette J, Dulic V
Mol Biol Cell, 15(9):3965-3976, 04 Jun 2004
Cited by: 116 articles | PMID: 15181148 | PMCID: PMC515331
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DNA damage checkpoint kinase Chk2 triggers replicative senescence.
Gire V, Roux P, Wynford-Thomas D, Brondello JM, Dulic V
EMBO J, 23(13):2554-2563, 10 Jun 2004
Cited by: 116 articles | PMID: 15192702 | PMCID: PMC449769
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TNFalpha induces sequential activation of Cdc42- and p38/p53-dependent pathways that antagonistically regulate filopodia formation.
Gadea G, Roger L, Anguille C, de Toledo M, Gire V, Roux P
J Cell Sci, 117(pt 26):6355-6364, 23 Nov 2004
Cited by: 31 articles | PMID: 15561766
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Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts.
Baus F, Gire V, Fisher D, Piette J, Dulić V
EMBO J, 22(15):3992-4002, 01 Aug 2003
Cited by: 101 articles | PMID: 12881433 | PMCID: PMC169060
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PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS.
Gire V, Marshall C, Wynford-Thomas D
Oncogene, 19(19):2269-2276, 01 May 2000
Cited by: 37 articles | PMID: 10822377
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RAS oncogene activation induces proliferation in normal human thyroid epithelial cells without loss of differentiation.
Gire V, Wynford-Thomas D
Oncogene, 19(6):737-744, 01 Feb 2000
Cited by: 27 articles | PMID: 10698491
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Contrasting effects of activating mutations of GalphaS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells.
Ludgate M, Gire V, Crisp M, Ajjan R, Weetman A, Ivan M, Wynford-Thomas D
Oncogene, 18(34):4798-4807, 01 Aug 1999
Cited by: 13 articles | PMID: 10490813
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Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras.
Gire V, Marshall CJ, Wynford-Thomas D
Oncogene, 18(34):4819-4832, 01 Aug 1999
Cited by: 26 articles | PMID: 10490815
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Multiple connexin expression in peripheral nerve, Schwann cells, and Schwannoma cells.
Mambetisaeva ET, Gire V, Evans WH
J Neurosci Res, 57(2):166-175, 01 Jul 1999
Cited by: 29 articles | PMID: 10398294
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Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis.
Bond JA, Haughton MF, Rowson JM, Smith PJ, Gire V, Wynford-Thomas D, Wyllie FS
Mol Cell Biol, 19(4):3103-3114, 01 Apr 1999
Cited by: 66 articles | PMID: 10082577 | PMCID: PMC84104
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Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies.
Gire V, Wynford-Thomas D
Mol Cell Biol, 18(3):1611-1621, 01 Mar 1998
Cited by: 83 articles | PMID: 9488478 | PMCID: PMC108876
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[Origin and progression of thyroid epithelial tumors: molecular and cellular mechanisms].
Gire V, Wynford-Thomas D
Arch Anat Cytol Pathol, 46(1-2):11-18, 01 Jan 1998
Cited by: 0 articles | PMID: 9754356
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Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.
Bond J, Haughton M, Blaydes J, Gire V, Wynford-Thomas D, Wyllie F
Oncogene, 13(10):2097-2104, 01 Nov 1996
Cited by: 76 articles | PMID: 8950976
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Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.
Blaydes JP, Gire V, Rowson JM, Wynford-Thomas D
Oncogene, 14(15):1859-1868, 01 Apr 1997
Cited by: 38 articles | PMID: 9150392
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Calcium is transported into the lumen of pig thyroid follicles by fluid phase basolateral to apical transcytosis.
Fonlupt P, Audebet C, Gire V, Bernier-Valentin F, Rousset B
J Cell Physiol, 171(1):43-51, 01 Apr 1997
Cited by: 1 article | PMID: 9119891
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