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The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer.
Van Emmenis L, Ku SY, Gayvert K, Branch JR, Brady NJ, Basu S, Russell M, Cyrta J, Vosoughi A, Sailer V, Alnajar H, Dardenne E, Koumis E, Puca L, Robinson BD, Feldkamp MD, Winkis A, Majewski N, Rupnow B, [...] Rickman DS
Cancer Res Commun, 3(8):1447-1459, 03 Aug 2023
Cited by: 0 articles | PMID: 37546702 | PMCID: PMC10401480
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Immune and pathologic responses in patients with localized prostate cancer who received daratumumab (anti-CD38) or edicotinib (CSF-1R inhibitor).
Siddiqui BA, Chapin BF, Jindal S, Duan F, Basu S, Yadav SS, Gu AD, Espejo AB, Kinder M, Pettaway CA, Ward JF, Tidwell RSS, Troncoso P, Corn PG, Logothetis CJ, Knoblauch R, Hutnick N, Gottardis M, Drake CG, [...] Subudhi SK
J Immunother Cancer, 11(3):e006262, 01 Mar 2023
Cited by: 4 articles | PMID: 36948506 | PMCID: PMC10040066
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The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer.
Padmakar Darne C, Velaparthi U, Saulnier M, Frennesson D, Liu P, Huang A, Tokarski J, Fura A, Spires T, Newitt J, Spires VM, Obermeier MT, Elzinga PA, Gottardis MM, Jayaraman L, Vite GD, Balog A
Bioorg Med Chem Lett, 75:128951, 27 Aug 2022
Cited by: 5 articles | PMID: 36031020
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Safety and preliminary immunogenicity of JNJ-64041809, a live-attenuated, double-deleted Listeria monocytogenes-based immunotherapy, in metastatic castration-resistant prostate cancer.
Drake CG, Pachynski RK, Subudhi SK, McNeel DG, Antonarakis ES, Bauer TM, Lauer P, Brockstedt D, Patricia D, Wade M, Zudaire E, Bandyopadhyay N, Parasrampuria DA, Girgis S, Mason GE, Knoblauch RE, Stone N, Infante JR, Gottardis MM, Fong L
Prostate Cancer Prostatic Dis, 25(2):219-228, 13 Jul 2021
Cited by: 14 articles | PMID: 34257408 | PMCID: PMC9184270
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Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer.
Branch JR, Bush TL, Pande V, Connolly PJ, Zhang Z, Hickson I, Ondrus J, Jaensch S, Bischoff JR, Habineza G, Van Hecke G, Meerpoel L, Packman K, Parrett CJ, Chong YT, Gottardis MM, Bignan G
Mol Cancer Ther, 20(5):763-774, 01 Mar 2021
Cited by: 2 articles | PMID: 33649102
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Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).
Zhang Z, Connolly PJ, Lim HK, Pande V, Meerpoel L, Teleha C, Branch JR, Ondrus J, Hickson I, Bush T, Luistro L, Packman K, Bischoff JR, Ibrahim S, Parrett C, Chong Y, Gottardis MM, Bignan G
J Med Chem, 64(2):909-924, 20 Jan 2021
Cited by: 6 articles | PMID: 33470111
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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.
Richters A, Doyle SK, Freeman DB, Lee C, Leifer BS, Jagannathan S, Kabinger F, Koren JV, Struntz NB, Urgiles J, Stagg RA, Curtin BH, Chatterjee D, Mathea S, Mikochik PJ, Hopkins TD, Gao H, Branch JR, Xin H, [...] Koehler AN
Cell Chem Biol, 28(2):134-147.e14, 20 Oct 2020
Cited by: 27 articles | PMID: 33086052
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Stereotactic Radiofrequency Ablation of an Unresectable Intrahepatic Cholangiocarcinoma (ICC): Transforming an Aggressive Disease into a Chronic Condition.
Laimer G, Jaschke N, Gottardis M, Schullian P, Putzer D, Sturm W, Bale R
Cardiovasc Intervent Radiol, 43(5):791-796, 11 Mar 2020
Cited by: 2 articles | PMID: 32162024 | PMCID: PMC7196948
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Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer.
Huang A, Jayaraman L, Fura A, Vite GD, Trainor GL, Gottardis MM, Spires TE, Spires VM, Rizzo CA, Obermeier MT, Elzinga PA, Todderud G, Fan Y, Newitt JA, Beyer SM, Zhu Y, Warrack BM, Goodenough AK, Tebben AJ, [...] Balog A
ACS Med Chem Lett, 7(1):40-45, 02 Dec 2015
Cited by: 3 articles | PMID: 26819663 | PMCID: PMC4716597
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Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.
Balog A, Rampulla R, Martin GS, Krystek SR, Attar R, Dell-John J, DiMarco JD, Fairfax D, Gougoutas J, Holst CL, Nation A, Rizzo C, Rossiter LM, Schweizer L, Shan W, Spergel S, Spires T, Cornelius G, Gottardis M, [...] Salvati ME
ACS Med Chem Lett, 6(8):908-912, 19 Jun 2015
Cited by: 10 articles | PMID: 26288692 | PMCID: PMC4538445
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Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport.
Talbott RL, Borzilleri RM, Chaudhry C, Fargnoli J, Shen H, Fairchild C, Barnhart B, Ortega M, McDonagh TE, Vuppugalla R, Vite GD, Hunt JT, Gottardis M, Naglich JG
Exp Cell Res, 338(2):251-260, 21 Aug 2015
Cited by: 3 articles | PMID: 26302264
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9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors.
Zimmermann K, Sang X, Mastalerz HA, Johnson WL, Zhang G, Liu Q, Batt D, Lombardo LJ, Vyas D, Trainor GL, Tokarski JS, Lorenzi MV, You D, Gottardis MM, Lippy J, Khan J, Sack JS, Purandare AV
Bioorg Med Chem Lett, 25(14):2809-2812, 11 May 2015
Cited by: 5 articles | PMID: 25987372
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Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers.
Modugno M, Banfi P, Gasparri F, Borzilleri R, Carter P, Cornelius L, Gottardis M, Lee V, Mapelli C, Naglich JG, Tebben A, Vite G, Pastori W, Albanese C, Corti E, Ballinari D, Galvani A
Exp Cell Res, 332(2):267-277, 05 Dec 2014
Cited by: 20 articles | PMID: 25486070
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Combined Inhibition of IGF-1R/IR and Src family kinases enhances antitumor effects in prostate cancer by decreasing activated survival pathways.
Dayyani F, Parikh NU, Varkaris AS, Song JH, Moorthy S, Chatterji T, Maity SN, Wolfe AR, Carboni JM, Gottardis MM, Logothetis CJ, Gallick GE
PLoS One, 7(12):e51189, 26 Dec 2012
Cited by: 25 articles | PMID: 23300537 | PMCID: PMC3530555
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IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein.
Jenkins CE, Shevchuk OO, Giambra V, Lam SH, Carboni JM, Gottardis MM, Holzenberger M, Pollak M, Humphries RK, Weng AP
Exp Hematol, 40(9):715-723.e6, 18 May 2012
Cited by: 14 articles | PMID: 22613471
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IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer.
Dool CJ, Mashhedi H, Zakikhani M, David S, Zhao Y, Birman E, Carboni JM, Gottardis M, Blouin MJ, Pollak M
Endocr Relat Cancer, 18(6):699-709, 14 Nov 2011
Cited by: 24 articles | PMID: 21946410
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IGFBP ratio confers resistance to IGF targeting and correlates with increased invasion and poor outcome in breast tumors.
Becker MA, Hou X, Harrington SC, Weroha SJ, Gonzalez SE, Jacob KA, Carboni JM, Gottardis MM, Haluska P
Clin Cancer Res, 18(6):1808-1817, 27 Jan 2012
Cited by: 23 articles | PMID: 22287600 | PMCID: PMC3306532
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Dual IGF-1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer.
Hou X, Huang F, Macedo LF, Harrington SC, Reeves KA, Greer A, Finckenstein FG, Brodie A, Gottardis MM, Carboni JM, Haluska P
Cancer Res, 71(24):7597-7607, 31 Oct 2011
Cited by: 48 articles | PMID: 22042792 | PMCID: PMC4004036
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Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2.
Purandare AV, McDevitt TM, Wan H, You D, Penhallow B, Han X, Vuppugalla R, Zhang Y, Ruepp SU, Trainor GL, Lombardo L, Pedicord D, Gottardis MM, Ross-Macdonald P, de Silva H, Hosbach J, Emanuel SL, Blat Y, Fitzpatrick E, [...] Lorenzi MV
Leukemia, 26(2):280-288, 21 Oct 2011
Cited by: 45 articles | PMID: 22015772
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High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.
Medyouf H, Gusscott S, Wang H, Tseng JC, Wai C, Nemirovsky O, Trumpp A, Pflumio F, Carboni J, Gottardis M, Pollak M, Kung AL, Aster JC, Holzenberger M, Weng AP
J Exp Med, 208(9):1809-1822, 01 Aug 2011
Cited by: 109 articles | PMID: 21807868 | PMCID: PMC3171095
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Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors.
Ross-Macdonald P, de Silva H, Patel V, Truong A, He A, Neuhaus I, Tilford C, Ji R, Siemers N, Greer A, Carboni J, Gottardis M, Menard K, Lee F, Dodier M, Frennesson D, Sampognaro A, Saulnier M, Trainor G, [...] Wittman M
Bioorg Med Chem, 20(6):1961-1972, 06 Nov 2011
Cited by: 1 article | PMID: 22137930
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A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation.
Tognon CE, Martin MJ, Moradian A, Trigo G, Rotblat B, Cheng SW, Pollard M, Uy E, Chow C, Carboni JM, Gottardis MM, Pollak M, Morin GB, Sorensen PH
Oncogene, 31(10):1334-1340, 01 Aug 2011
Cited by: 14 articles | PMID: 21804605
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High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy.
Litzenburger BC, Creighton CJ, Tsimelzon A, Chan BT, Hilsenbeck SG, Wang T, Carboni JM, Gottardis MM, Huang F, Chang JC, Lewis MT, Rimawi MF, Lee AV
Clin Cancer Res, 17(8):2314-2327, 22 Dec 2010
Cited by: 84 articles | PMID: 21177763 | PMCID: PMC3073089
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Pyrrolo[1,2-f]triazines as JAK2 inhibitors: achieving potency and selectivity for JAK2 over JAK3.
Harikrishnan LS, Kamau MG, Wan H, Inghrim JA, Zimmermann K, Sang X, Mastalerz HA, Johnson WL, Zhang G, Lombardo LJ, Poss MA, Trainor GL, Tokarski JS, Lorenzi MV, You D, Gottardis MM, Baldwin KF, Lippy J, Nirschl DS, [...] Purandare AV
Bioorg Med Chem Lett, 21(5):1425-1428, 11 Jan 2011
Cited by: 10 articles | PMID: 21282055
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Phase I dose-escalation study of the novel antiandrogen BMS-641988 in patients with castration-resistant prostate cancer.
Rathkopf D, Liu G, Carducci MA, Eisenberger MA, Anand A, Morris MJ, Slovin SF, Sasaki Y, Takahashi S, Ozono S, Fung NK, Cheng S, Gan J, Gottardis M, Obermeier MT, Reddy J, Zhang S, Vakkalagadda BJ, Alland L, [...] Prostate Cancer Clinical Trials Consortium
Clin Cancer Res, 17(4):880-887, 03 Dec 2010
Cited by: 21 articles | PMID: 21131556 | PMCID: PMC3070382
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