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Search life-sciences literature (45,103,589 articles, preprints and more)

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14-3-3σ/Stratifin and p21 limit AKT-related malignant progression in skin carcinogenesis following MDM2-associated p53 loss.
McMenemy CM, Guo D, Quinn JA, Greenhalgh DA
Mol Carcinog, 63(9):1768-1782, 13 Jun 2024
Cited by: 1 article | PMID: 38869281
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Epidermal ROCK2 induces AKT1/GSK3β/β-catenin, NFκB and dermal tenascin C; but enhanced differentiation and p53/p21 inhibit papilloma.
Masre SF, Rath N, Olson MF, Greenhalgh DA
Carcinogenesis, 41(10):1409-1420, 01 Oct 2020
Cited by: 3 articles | PMID: 31907522 | PMCID: PMC7566339
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Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.
Unbekandt M, Belshaw S, Bower J, Clarke M, Cordes J, Crighton D, Croft DR, Drysdale MJ, Garnett MJ, Gill K, Gray C, Greenhalgh DA, Hall JAM, Konczal J, Lilla S, McArthur D, McConnell P, McDonald L, McGarry L, [...] Olson MF
Cancer Res, 78(8):2096-2114, 30 Jan 2018
Cited by: 21 articles | PMID: 29382705 | PMCID: PMC5901721
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Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein.
Samuel MS, Rath N, Masre SF, Boyle ST, Greenhalgh DA, Kochetkova M, Bryson S, Stevenson D, Olson MF
Genesis, 54(12):636-646, 08 Nov 2016
Cited by: 6 articles | PMID: 27775859
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ROCK2/ras^Ha co-operation induces malignant conversion via p53 loss, elevated NF-κB and tenascin C-associated rigidity, but p21 inhibits ROCK2/NF-κB-mediated progression.
Masre SF, Rath N, Olson MF, Greenhalgh DA
Oncogene, 36(18):2529-2542, 19 Dec 2016
Cited by: 8 articles | PMID: 27991921
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PTEN ablation in Ras(Ha)/Fos skin carcinogenesis invokes p53-dependent p21 to delay conversion while p53-independent p21 limits progression via cyclin D1/E2 inhibition.
Macdonald FH, Yao D, Quinn JA, Greenhalgh DA
Oncogene, 33(32):4132-4143, 16 Sep 2013
Cited by: 8 articles | PMID: 24037529
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Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity.
Yao D, Alexander CL, Quinn JA, Chan WC, Wu H, Greenhalgh DA
J Cell Sci, 121(pt 10):1758-1769, 29 Apr 2008
Cited by: 11 articles | PMID: 18445683
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PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways.
Yao D, Alexander CL, Quinn JA, Porter MJ, Wu H, Greenhalgh DA
Cancer Res, 66(3):1302-1312, 01 Feb 2006
Cited by: 24 articles | PMID: 16452183
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Flow imaging by use of femtosecond-laser-induced two-photon fluorescence.
Kelman JB, Greenhalgh DA, Ramsay E, Xiao D, Reid DT
Opt Lett, 29(16):1873-1875, 01 Aug 2004
Cited by: 3 articles | PMID: 15357344
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Amending of fluorescence sensor signal localization in human skin by matching of the refractive index.
Churmakov DY, Meglinski IV, Greenhalgh DA
J Biomed Opt, 9(2):339-346, 01 Mar 2004
Cited by: 12 articles | PMID: 15065900
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Influence of refractive index matching on the photon diffuse reflectance.
Churmakov DY, Meglinski IV, Greenhalgh DA
Phys Med Biol, 47(23):4271-4285, 01 Dec 2002
Cited by: 19 articles | PMID: 12502049
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Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis.
Wang XJ, Greenhalgh DA, Donehower LA, Roop DR
Mol Carcinog, 29(2):67-75, 01 Oct 2000
Cited by: 7 articles | PMID: 11074603
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Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation.
Wang XJ, Greenhalgh DA, Roop DR
Mol Carcinog, 27(3):200-209, 01 Mar 2000
Cited by: 12 articles | PMID: 10708482
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Patent protection for protein structures and databases.
Meyers TC, Turano TA, Greenhalgh DA, Waller PR
Nat Struct Biol, 7 Suppl:950-952, 01 Nov 2000
Cited by: 4 articles | PMID: 11103996
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12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation.
Wang XJ, Liefer KM, Greenhalgh DA, Roop DR
Mol Carcinog, 26(4):305-311, 01 Dec 1999
Cited by: 11 articles | PMID: 10569807
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Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis.
Wang XJ, Greenhalgh DA, Jiang A, He D, Zhong L, Medina D, Brinkley BR, Roop DR
Oncogene, 17(1):35-45, 01 Jul 1998
Cited by: 50 articles | PMID: 9671312
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Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function.
Wang XJ, Greenhalgh DA, Jiang A, He D, Zhong L, Brinkley BR, Roop DR
Mol Carcinog, 23(3):185-192, 01 Nov 1998
Cited by: 31 articles | PMID: 9833779
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Ex vivo and in vivo adenovirus-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model.
Bonnekoh B, Greenhalgh DA, Chen SH, Block A, Rich SS, Krieg T, Woo SL, Roop DR
J Invest Dermatol, 110(6):867-871, 01 Jun 1998
Cited by: 19 articles | PMID: 9620291
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Adenovirus-mediated ex vivo immunogene and in vivo combination gene therapy strategies induce a systemic anti-tumor immune defense in the mouse B16 melanoma model.
Bonnekoh B, Greenhalgh DA, Chen SH, Bickenbach J, Block A, Rich SS, Krieg T, Woo SL, Roop DR
Adv Exp Med Biol, 451:335-343, 01 Jan 1998
Cited by: 2 articles | PMID: 10026893
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Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition.
Wang XJ, Greenhalgh DA, Bickenbach JR, Jiang A, Bundman DS, Krieg T, Derynck R, Roop DR
Proc Natl Acad Sci U S A, 94(6):2386-2391, 01 Mar 1997
Cited by: 90 articles | PMID: 9122204 | PMCID: PMC20097
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Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha.
Greenhalgh DA, Wang XJ, Donehower LA, Roop DR
Cancer Res, 56(19):4413-4423, 01 Oct 1996
Cited by: 33 articles | PMID: 8813135
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Adenoviral-mediated herpes simplex virus-thymidine kinase gene transfer in vivo for treatment of experimental human melanoma.
Bonnekoh B, Greenhalgh DA, Bundman DS, Kosai K, Chen SH, Finegold MJ, Krieg T, Woo SL, Roop R
J Invest Dermatol, 106(6):1163-1168, 01 Jun 1996
Cited by: 10 articles | PMID: 8752651
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Epidermal expression of transforming growth factor-alpha in transgenic mice: induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression.
Wang XJ, Greenhalgh DA, Eckhardt JN, Rothnagel JA, Roop DR
Mol Carcinog, 10(1):15-22, 01 May 1994
Cited by: 28 articles | PMID: 8185825
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A collision gradient method to determine the immersion depth of nitroxides in lipid bilayers: application to spin-labeled mutants of bacteriorhodopsin.
Altenbach C, Greenhalgh DA, Khorana HG, Hubbell WL
Proc Natl Acad Sci U S A, 91(5):1667-1671, 01 Mar 1994
Cited by: 238 articles | PMID: 8127863 | PMCID: PMC43224
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Multistage epidermal carcinogenesis in transgenic mice: cooperativity and paradox.
Greenhalgh DA, Wang XJ, Roop DR
J Investig Dermatol Symp Proc, 1(2):162-176, 01 Apr 1996
Cited by: 2 articles | PMID: 9627712
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