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Search life-sciences literature (45,104,206 articles, preprints and more)

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Structure-Guided Discovery of <i>cis</i>-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors.
Kuhn B, Ritter M, Hornsperger B, Bell C, Kocer B, Rombach D, Lutz MDR, Gobbi L, Kuratli M, Bartelmus C, Bürkler M, Koller R, Tosatti P, Ruf I, Guerard M, Pavlovic A, Stephanus J, O'Hara F, Wetzl D, [...] Grether U
J Med Chem, 67(20):18448-18464, 03 Oct 2024
Cited by: 0 articles | PMID: 39360636
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Identification of (R)-[¹⁸F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development.
He Y, Krämer SD, Grether U, Wittwer MB, Collin L, Kuhn B, Topp A, Heer D, O'Hara F, Honer M, Pavlovic A, Richter H, Ritter M, Rombach D, Keller C, Gobbi L, Mu L
J Nucl Med, 65(2):300-305, 01 Feb 2024
Cited by: 1 article | PMID: 38164615
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Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)-[¹¹C]YH132: Application in Drug Development and Neurodegenerative Diseases.
He Y, Delparente A, Jie CVML, Keller C, Humm R, Heer D, Collin L, Schibli R, Gobbi L, Grether U, Mu L
Chembiochem, 25(7):e202300819, 05 Mar 2024
Cited by: 0 articles | PMID: 38441502
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Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization.
Butini S, Grether U, Jung KM, Ligresti A, Allarà M, Postmus AGJ, Maramai S, Brogi S, Papa A, Carullo G, Sykes D, Veprintsev D, Federico S, Grillo A, Di Guglielmo B, Ramunno A, Stevens AF, Heer D, Lamponi S, [...] Campiani G
J Med Chem, 67(3):1758-1782, 19 Jan 2024
Cited by: 0 articles | PMID: 38241614
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Discovery of Orally Available and Brain Penetrant AEP Inhibitors.
Krummenacher D, He W, Kuhn B, Schnider C, Beurier A, Brom V, Sivasothy T, Marty C, Tosstorff A, Hewings DS, Mesch S, Pinard E, Brändlin M, Hochstrasser R, Westwood P, Rothe J, Kronenberger A, Morandi F, Gutbier S, [...] Bartels B
J Med Chem, 66(24):17026-17043, 13 Dec 2023
Cited by: 1 article | PMID: 38090813
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Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct.
Gehrlein A, Udayar V, Anastasi N, Morella ML, Ruf I, Brugger D, von der Mark S, Thoma R, Rufer A, Heer D, Pfahler N, Jochner A, Niewoehner J, Wolf L, Fueth M, Ebeling M, Villaseñor R, Zhu Y, Deen MC, [...] Jagasia R
Nat Commun, 14(1):2057, 12 Apr 2023
Cited by: 12 articles | PMID: 37045813 | PMCID: PMC10097658
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A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature.
Kemble AM, Hornsperger B, Ruf I, Richter H, Benz J, Kuhn B, Heer D, Wittwer M, Engelhardt B, Grether U, Collin L
PLoS One, 17(9):e0268590, 09 Sep 2022
Cited by: 0 articles | PMID: 36084029 | PMCID: PMC9462760
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Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain.
He Y, Grether U, Taddio MF, Meier C, Keller C, Edelmann MR, Honer M, Huber S, Wittwer MB, Heer D, Richter H, Collin L, Hug MN, Hilbert M, Postmus AGJ, Stevens AF, van der Stelt M, Krämer SD, Schibli R, [...] Gobbi LC
Eur J Med Chem, 243:114750, 09 Sep 2022
Cited by: 1 article | PMID: 36137365
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A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature
Kemble A, Hornsperger B, Ruf I, Richter H, Benz J, Kuhn B, Heer D, Wittwer M, Engelhardt B, Grether U, Collin L
bioRxiv, 04 May 2022
Cited by: 0 articles | PPR: PPR489427
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Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold.
He Y, Gobbi LC, Herde AM, Rombach D, Ritter M, Kuhn B, Wittwer MB, Heer D, Hornsperger B, Bell C, O'Hara F, Benz J, Honer M, Keller C, Collin L, Richter H, Schibli R, Grether U, Mu L
Nucl Med Biol, 108-109:24-32, 23 Feb 2022
Cited by: 1 article | PMID: 35248850
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Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging.
He Y, Schild M, Grether U, Benz J, Leibrock L, Heer D, Topp A, Collin L, Kuhn B, Wittwer M, Keller C, Gobbi LC, Schibli R, Mu L
J Med Chem, 65(3):2191-2207, 28 Jan 2022
Cited by: 4 articles | PMID: 35089028
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6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects.
Imamura Y, Tsuruya Y, Damme K, Heer D, Kumagai Y, Maeda K, Murayama N, Okudaira N, Kurihara A, Izumi T, Sugiyama Y, Kusuhara H
Drug Metab Dispos, 42(4):685-694, 31 Jan 2014
Cited by: 34 articles | PMID: 24487120
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Dynamic metabolomics differentiates between carbon and energy starvation in recombinant Saccharomyces cerevisiae fermenting xylose.
Bergdahl B, Heer D, Sauer U, Hahn-Hägerdal B, van Niel EW
Biotechnol Biofuels, 5(1):34, 15 May 2012
Cited by: 35 articles | PMID: 22587303 | PMCID: PMC3462113
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High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry.
Fuhrer T, Heer D, Begemann B, Zamboni N
Anal Chem, 83(18):7074-7080, 18 Aug 2011
Cited by: 218 articles | PMID: 21830798
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Source-pathway separation of multiple contaminants during a rainfall-runoff event in an artificially drained agricultural watershed.
Tomer MD, Wilson CG, Moorman TB, Cole KJ, Heer D, Isenhart TM
J Environ Qual, 39(3):882-895, 13 Apr 2010
Cited by: 9 articles | PMID: 20400584
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Resistance of Saccharomyces cerevisiae to high concentrations of furfural is based on NADPH-dependent reduction by at least two oxireductases.
Heer D, Heine D, Sauer U
Appl Environ Microbiol, 75(24):7631-7638, 23 Oct 2009
Cited by: 85 articles | PMID: 19854918 | PMCID: PMC2794096
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Identification of furfural as a key toxin in lignocellulosic hydrolysates and evolution of a tolerant yeast strain.
Heer D, Sauer U
Microb Biotechnol, 1(6):497-506, 04 Aug 2008
Cited by: 114 articles | PMID: 21261870 | PMCID: PMC3815291
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Reliability of a measurement of neck flexor muscle endurance.
Harris KD, Heer DM, Roy TC, Santos DM, Whitman JM, Wainner RS
Phys Ther, 85(12):1349-1355, 01 Dec 2005
Cited by: 104 articles | PMID: 16305273
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Amphotericin B as a potential probe of the physical state of vesicle membranes.
Zumbuehl A, Stano P, Heer D, Walde P, Carreira EM
Org Lett, 6(21):3683-3686, 01 Oct 2004
Cited by: 18 articles | PMID: 15469323
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The unauthorized Mexican immigrant population and welfare in Los Angeles County: a comparative statistical analysis.
Marcelli EA, Heer DM
Sociol Perspect, 41(2):279-302, 01 Jan 1998
Cited by: 1 article | PMID: 12294132
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Unauthorized Mexican workers in the 1990 Los Angeles County labour force.
Marcelli EA, Heer DM
Int Migr, 35(1):59-83, 01 Jan 1997
Cited by: 8 articles | PMID: 12292469
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Variations in fertility and earning patterns among immigrants in the United States, 1970-1980: assimilation or disruption?
Gorwaney N, Van Arsdol MD, Heer DM, Schuerman LA
Int Migr, 28(4):451-475, 01 Dec 1990
Cited by: 2 articles | PMID: 12159560
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Does choice make a difference to contraceptive use? Evidence from east Java.
Pariani S, Heer DM, Van Arsdol MD
Stud Fam Plann, 22(6):384-390, 01 Nov 1991
Cited by: 55 articles | PMID: 1792678
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Migration from Latin American countries to the United States: the economic, social and reproductive lives of Hispanic female immigrants, 1980.
Gorwaney N, Van Arsdol MD, Heer DM, Schuerman LA
Int Migr, 29(4):573-599, 01 Dec 1991
Cited by: 2 articles | PMID: 12159612
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Comparison of two methods for estimating the number of undocumented Mexican adults in Los Angeles County.
Heer DM, Passel JF
Int Migr Rev, 21(4):1446-1473, 01 Jan 1987
Cited by: 6 articles | PMID: 12280920
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