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Search life-sciences literature (45,103,589 articles, preprints and more)

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Meige syndrome in the spectrum of Lewy body disease.
Mark MH, Sage JI, Dickson DW, Heikkila RE, Manzino L, Schwarz KO, Duvoisin RC
Neurology, 44(8):1432-1436, 01 Aug 1994
Cited by: 18 articles | PMID: 8058144
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Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 1: Systemic administration.
Giovanni A, Sieber BA, Heikkila RE, Sonsalla PK
J Pharmacol Exp Ther, 270(3):1000-1007, 01 Sep 1994
Cited by: 71 articles | PMID: 7932147
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Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 2: Central administration of 1-methyl-4-phenylpyridinium.
Giovanni A, Sonsalla PK, Heikkila RE
J Pharmacol Exp Ther, 270(3):1008-1014, 01 Sep 1994
Cited by: 54 articles | PMID: 7932148
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Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration.
Saporito MS, Heikkila RE, Youngster SK, Nicklas WJ, Geller HM
J Pharmacol Exp Ther, 260(3):1400-1409, 01 Mar 1992
Cited by: 22 articles | PMID: 1312170
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Biochemical mechanisms underlying MPTP-induced and idiopathic parkinsonism. New vistas.
Singer TP, Ramsay RR, Sonsalla PK, Nicklas WJ, Heikkila RE
Adv Neurol, 60:300-305, 01 Jan 1993
Cited by: 8 articles | PMID: 8380523
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Mitochondrial mechanisms of neurotoxicity.
Nicklas WJ, Saporito M, Basma A, Geller HM, Heikkila RE
Ann N Y Acad Sci, 648:28-36, 01 May 1992
Cited by: 11 articles | PMID: 1637057
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In vivo and in vitro pharmacologic profile of two new irreversible MAO-B inhibitors: MDL 72,974A and fluorodeprenyl.
Terleckyj IA, Heikkila RE
Ann N Y Acad Sci, 648:365-367, 01 May 1992
Cited by: 2 articles | PMID: 1637071
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Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice.
Sonsalla PK, Riordan DE, Heikkila RE
J Pharmacol Exp Ther, 256(2):506-512, 01 Feb 1991
Cited by: 117 articles | PMID: 1671596
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The MPTP-treated mouse as a model of parkinsonism: how good is it?
Heikkila RE, Sonsalla PK
Neurochem Int, 20 Suppl:299S-303S, 01 Mar 1992
Cited by: 41 articles | PMID: 1365446
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1-Methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells is enhanced by preventing glycolysis.
Basma AN, Heikkila RE, Saporito MS, Philbert M, Geller HM, Nicklas WJ
J Neurochem, 58(3):1052-1059, 01 Mar 1992
Cited by: 28 articles | PMID: 1737983
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Potentiation by the tetraphenylboron anion of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its pyridinium metabolite.
Heikkila RE, Hwang J, Ofori S, Geller HM, Nicklas WJ
J Neurochem, 54(3):743-750, 01 Mar 1990
Cited by: 19 articles | PMID: 2303810
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Monoamine oxidase and the bioactivation of MPTP and related neurotoxins: relevance to DATATOP.
Heikkila RE, Terleckyj I, Sieber BA
J Neural Transm Suppl, 32:217-227, 01 Jan 1990
Cited by: 6 articles | PMID: 2128498
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Correlation between the neostriatal content of the 1-methyl-4-phenylpyridinium species and dopaminergic neurotoxicity following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to several strains of mice.
Giovanni A, Sieber BA, Heikkila RE, Sonsalla PK
J Pharmacol Exp Ther, 257(2):691-697, 01 May 1991
Cited by: 69 articles | PMID: 2033514
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells: role of monoamine oxidase A.
Basma AN, Heikkila RE, Nicklas WJ, Giovanni A, Geller HM
J Neurochem, 55(3):870-877, 01 Sep 1990
Cited by: 13 articles | PMID: 2384758
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4'-alkylated analogs of 1-methyl-4-phenylpyridinium ion are potent inhibitors of mitochondrial respiration.
Youngster SK, Gluck MR, Heikkila RE, Nicklas WJ
Biochem Biophys Res Commun, 169(2):758-764, 01 Jun 1990
Cited by: 13 articles | PMID: 2357232
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Experience with continuous enteral levodopa infusions in the treatment of 9 patients with advanced Parkinson's disease.
Sage JI, Trooskin S, Sonsalla PK, Heikkila RE
Neurology, 39(11 suppl 2):60-3; discussion 72-3, 01 Nov 1989
Cited by: 7 articles | PMID: 2586763
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Steady plasma levodopa concentrations required for good clinical response to CR-4 in patients with 'on-off'.
McHale DM, Sage JI, Sonsalla PK, Heikkila RE, Duvoisin RC
Eur Neurol, 30(2):90-92, 01 Jan 1990
Cited by: 1 article | PMID: 2340841
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Structural dependence of the inhibition of mitochondrial respiration and of NADH oxidase by 1-methyl-4-phenylpyridinium (MPP+) analogs and their energized accumulation by mitochondria.
Ramsay RR, Youngster SK, Nicklas WJ, McKeown KA, Jin YZ, Heikkila RE, Singer TP
Proc Natl Acad Sci U S A, 86(23):9168-9172, 01 Dec 1989
Cited by: 33 articles | PMID: 2594758 | PMCID: PMC298455
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Oxidation of analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by monoamine oxidases A and B and the inhibition of monoamine oxidases by the oxidation products.
Youngster SK, McKeown KA, Jin YZ, Ramsay RR, Heikkila RE, Singer TP
J Neurochem, 53(6):1837-1842, 01 Dec 1989
Cited by: 33 articles | PMID: 2809594
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Clinical experience with duodenal infusions of levodopa for the treatment of motor fluctuations in Parkinson's disease.
Sage JI, Sonsalla PK, McHale DM, Heikkila RE, Duvoisin RC
Adv Neurol, 53:383-386, 01 Jan 1990
Cited by: 12 articles | PMID: 2122646
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Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.
Heikkila RE, Sieber BA, Manzino L, Sonsalla PK
Mol Chem Neuropathol, 10(3):171-183, 01 Jun 1989
Cited by: 90 articles | PMID: 2669769
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Structure-activity study of the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. II. Evaluation of the biological activity of the pyridinium metabolites formed from the monoamine oxidase-catalyzed oxidation of MPTP analogs.
Youngster SK, Nicklas WJ, Heikkila RE
J Pharmacol Exp Ther, 249(3):829-835, 01 Jun 1989
Cited by: 22 articles | PMID: 2786565
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Continuous levodopa infusions to treat complex dystonia in Parkinson's disease.
Sage JI, McHale DM, Sonsalla P, Vitagliano D, Heikkila RE
Neurology, 39(7):888-891, 01 Jul 1989
Cited by: 20 articles | PMID: 2472582
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Attenuation by dopamine uptake blockers of the inhibitory effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and some of its analogs on NADH-linked metabolism in mouse neostriatal slices.
Ofori S, Heikkila RE, Nicklas WJ
J Pharmacol Exp Ther, 251(1):258-266, 01 Oct 1989
Cited by: 5 articles | PMID: 2571719
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Isolated jejunal pouches for levodopa delivery in parkinsonian patients with "on-off". Successful experimental model in dogs.
Sage JI, Trooskin S, Schuh L, Duncsak P, Sonsalla PK, Heikkila RE, Manzino L, Reddell M, Duvoisin RC
Clin Neuropharmacol, 11(3):212-220, 01 Jun 1988
Cited by: 0 articles | PMID: 3401857
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