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Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant Non-Small Cell Lung Cancer.
Araujo HA, Pechuan-Jorge X, Zhou T, Do MT, Hu X, Rojas Alvarez FR, Salvatierra ME, Ibarguen HP, Lee R, Raghulan R, Shah H, Moreno Ayala MA, Chen K, Tovbis Shifrin N, Wu S, Solis Soto LM, Negrao MV, Gibbons DL, Hong DS, [...] Skoulidis F
Cancer Discov, 14(11):2183-2208, 01 Nov 2024
Cited by: 0 articles | PMID: 38975897
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Impact of select actionable genomic alterations on efficacy of neoadjuvant immunotherapy in resectable non-small cell lung cancer.
Zhou N, Leung CH, William WN, Weissferdt A, Pataer A, Godoy MCB, Carter BW, Fossella FV, Tsao AS, Blumenschein GR, Le X, Zhang J, Skoulidis F, Kurie JM, Altan M, Lu C, Glisson BS, Byers LA, Elamin YY, [...] Cascone T
J Immunother Cancer, 12(10):e009677, 23 Oct 2024
Cited by: 0 articles | PMID: 39448200 | PMCID: PMC11499765
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Multiregional transcriptomic profiling provides improved prognostic insight in localized non-small cell lung cancer.
Li C, Nguyen TT, Li JR, Song X, Fujimoto J, Little L, Gumb C, Chow CB, Wistuba II, Futreal AP, Zhang J, Hubert SM, Heymach JV, Wu J, Amos CI, Zhang J, Cheng C
NPJ Precis Oncol, 8(1):225, 05 Oct 2024
Cited by: 0 articles | PMID: 39369068 | PMCID: PMC11455871
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CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.
Skoulidis F, Araujo HA, Do MT, Qian Y, Sun X, Cobo AG, Le JT, Montesion M, Palmer R, Jahchan N, Juan JM, Min C, Yu Y, Pan X, Arbour KC, Vokes N, Schmidt ST, Molkentine D, Owen DH, [...] Heymach JV
Nature, 635(8038):462-471, 09 Oct 2024
Cited by: 0 articles | PMID: 39385035 | PMCID: PMC11560846
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Molecular landscape of ERBB2 alterations in 3000 advanced NSCLC patients.
Hong L, Patel S, Drusbosky LM, Xiong Y, Chen R, Geng R, Heeke S, Nilsson M, Wu J, Heymach JV, Wang Y, Zhang J, Le X
NPJ Precis Oncol, 8(1):217, 01 Oct 2024
Cited by: 0 articles | PMID: 39354054 | PMCID: PMC11445497
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A Multicenter Open-Label Randomized Phase II Study of Osimertinib With and Without Ramucirumab in Tyrosine Kinase Inhibitor-Naïve <i>EGFR</i>-Mutant Metastatic Non-Small Cell Lung Cancer (RAMOSE trial).
Le X, Patel JD, Shum E, Baik C, Sanborn RE, Shu CA, Kim C, Fidler MJ, Hall R, Elamin YY, Tu J, Blumenschein G, Zhang J, Gibbons D, Gay C, Mohindra NA, Chae Y, Boumber Y, Sabari J, [...] Heymach JV
J Clin Oncol, JCO2400533, 08 Oct 2024
Cited by: 0 articles | PMID: 39378386
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Non-small-cell lung cancer.
Hendriks LEL, Remon J, Faivre-Finn C, Garassino MC, Heymach JV, Kerr KM, Tan DSW, Veronesi G, Reck M
Nat Rev Dis Primers, 10(1):71, 26 Sep 2024
Cited by: 0 articles | PMID: 39327441
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YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities.
Stewart CA, Diao L, Xi Y, Wang R, Ramkumar K, Serrano AG, Tanimoto A, Rodriguez BL, Morris BB, Shen L, Zhang B, Yang Y, Hamad SH, Cardnell RJ, Duarte A, Sahu M, Novegil VY, Weissman BE, Frumovitz M, [...] Gay CM
Clin Cancer Res, 30(20):4743-4754, 01 Oct 2024
Cited by: 0 articles | PMID: 39150543
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Zongertinib (BI 1810631), an irreversible HER2 TKI, spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers.
Wilding B, Woelflingseder L, Baum A, Chylinski K, Vainorius G, Gibson N, Waizenegger IC, Gerlach D, Augsten M, Spreitzer F, Shirai Y, Ikegami M, Tilandyova S, Scharn D, Pearson MA, Popow J, Obenauf AC, Yamamoto N, Kondo S, [...] Neumuller RA
Cancer Discov, 09 Sep 2024
Cited by: 0 articles | PMID: 39248702
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Author Correction: Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer.
Robichaux JP, Elamin YY, Tan Z, Carter BW, Zhang S, Liu S, Li S, Chen T, Poteete A, Estrada-Bernal A, Le AT, Truini A, Nilsson MB, Sun H, Roarty E, Goldberg SB, Brahmer JR, Altan M, Lu C, [...] Heymach JV
Nat Med, 30(9):2694-2695, 01 Sep 2024
Cited by: 0 articles | PMID: 39164519
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A Phase I Open-Label Study of Cediranib Plus Etoposide and Cisplatin as First-Line Therapy for Patients With Extensive-Stage Small-Cell Lung Cancer or Metastatic Neuroendocrine Non-Small-Cell Lung Cancer.
Concannon KF, Glisson BS, Doebele RC, Huang C, Marotti M, Camidge DR, Heymach JV
Clin Lung Cancer, 25(7):601-611, 01 Sep 2024
Cited by: 0 articles | PMID: 39307607
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Long-Term Clinical, Radiological, and Mortality Outcomes Following Pneumonitis in Nonsmall Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors: A Retrospective Analysis.
Soto-Lanza F, Glick L, Chan C, Zhong L, Wilson N, Faiz S, Gandhi S, Naing A, Heymach JV, Shannon VR, Franco-Vega M, Liao Z, Lin SH, Palaskas NL, Wu J, Shroff GS, Altan M, Sheshadri A
Clin Lung Cancer, 25(7):624-633.e2, 03 Aug 2024
Cited by: 0 articles | PMID: 39183094
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DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer
Morris BB, Heeke S, Xi Y, Diao L, Wang Q, Rocha P, Arriola E, Lee MC, Tyson DR, Concannon K, Ramkumar K, Stewart CA, Cardnell RJ, Wang R, Quaranta V, Wang J, Heymach JV, Nabet BY, Shames DS, [...] Byers LA
bioRxiv, 30 Jul 2024
Cited by: 0 articles | PPR: PPR888492
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Stereotactic ablative radiotherapy and immunotherapy for early-stage lung cancer - Authors' reply.
Chang JY, Verma V, Heymach JV
Lancet, 404(10449):241-242, 01 Jul 2024
Cited by: 0 articles | PMID: 39033005
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Mutational Characteristics and Clinical Outcomes for Lung Adenocarcinoma With EGFR Germline Mutations.
Pan K, Owens J, Elamin Y, Lu C, Routbort M, Zhang J, Fossella F, Negrao MV, Altan M, Pozadzides J, Skoulidis F, Tsao A, Cascone T, Heymach JV, Ostrin E, Le X
J Thorac Oncol, 19(10):1438-1448, 10 Jun 2024
Cited by: 1 article | PMID: 38866326
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Molecular classification and biomarkers of outcome with immunotherapy in extensive-stage small-cell lung cancer: analyses of the CASPIAN phase 3 study.
Xie M, Vuko M, Rodriguez-Canales J, Zimmermann J, Schick M, O'Brien C, Paz-Ares L, Goldman JW, Garassino MC, Gay CM, Heymach JV, Jiang H, Barrett JC, Stewart RA, Lai Z, Byers LA, Rudin CM, Shrestha Y
Mol Cancer, 23(1):115, 30 May 2024
Cited by: 1 article | PMID: 38811992 | PMCID: PMC11137956
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Three-Year Overall Survival Outcomes and Correlative Analyses in Patients With NSCLC and High (50%-89%) Versus Very High (≥90%) Programmed Death-Ligand 1 Expression Treated With First-Line Pembrolizumab or Cemiplimab.
Ricciuti B, Elkrief A, Lin J, Zhang J, Alessi JV, Lamberti G, Gandhi M, Di Federico A, Pecci F, Wang X, Makarem M, Murilo Hidalgo Filho C, Gorria T, Saini A, Pabon C, Lindsay J, Pfaff KL, Welsh EL, Nishino M, [...] Awad MM
JTO Clin Res Rep, 5(9):100675, 12 Apr 2024
Cited by: 0 articles | PMID: 39399157 | PMCID: PMC11471150
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Th2 Cells Are Associated with Tumor Recurrence Following Radiation.
Abdelhakiem MK, Bao R, Pifer PM, Molkentine D, Molkentine J, Hefner A, Beadle B, Heymach JV, Luke JJ, Ferris RL, Pickering CR, Wang JH, Patel RB, Skinner HD
Cancers (Basel), 16(8):1586, 20 Apr 2024
Cited by: 0 articles | PMID: 38672668 | PMCID: PMC11049347
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Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes.
Seth S, Chen R, Liu Y, Fujimoto J, Hong L, Reuben A, Varghese S, Behrens C, McDowell T, Soto LS, Haymaker C, Weissferdt A, Kalhor N, Wu J, Le X, Vokes NI, Cheng C, Heymach JV, Gibbons DL, [...] Zhang J
Cancer Innov, 3(3):e112, 15 Apr 2024
Cited by: 0 articles | PMID: 38947760
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Author Correction: An atlas of epithelial cell states and plasticity in lung adenocarcinoma.
Han G, Sinjab A, Rahal Z, Lynch AM, Treekitkarnmongkol W, Liu Y, Serrano AG, Feng J, Liang K, Khan K, Lu W, Hernandez SD, Liu Y, Cao X, Dai E, Pei G, Hu J, Abaya C, Gomez-Bolanos LI, [...] Kadara H
Nature, 628(8006):E1, 01 Apr 2024
Cited by: 0 articles | PMID: 38499683 | PMCID: PMC10990920
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Case report: Molecular profiling facilitates the diagnosis of a challenging case of lung cancer with choriocarcinoma features.
Li H, Hu X, Ning MS, Fuller GN, Stewart JM, Gilliam JC, Wu J, Le X, Vaporciyan AA, Lee JJ, Gibbons DL, Heymach JV, Futreal A, Zhang J
Front Oncol, 14:1324057, 25 Mar 2024
Cited by: 0 articles | PMID: 38590653 | PMCID: PMC10999639
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Comprehensive analysis of transcription factor-based molecular subtypes and their correlation to clinical outcomes in small-cell lung cancer.
Park S, Hong TH, Hwang S, Heeke S, Gay CM, Kim J, Jung HA, Sun JM, Ahn JS, Ahn MJ, Cho JH, Choi YS, Kim J, Shim YM, Kim HK, Byers LA, Heymach JV, Choi YL, Lee SH, Park K
EBioMedicine, 102:105062, 15 Mar 2024
Cited by: 2 articles | PMID: 38492534 | PMCID: PMC10959651
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An atlas of epithelial cell states and plasticity in lung adenocarcinoma.
Han G, Sinjab A, Rahal Z, Lynch AM, Treekitkarnmongkol W, Liu Y, Serrano AG, Feng J, Liang K, Khan K, Lu W, Hernandez SD, Liu Y, Cao X, Dai E, Pei G, Hu J, Abaya C, Gomez-Bolanos LI, [...] Kadara H
Nature, 627(8004):656-663, 28 Feb 2024
Cited by: 12 articles | PMID: 38418883 | PMCID: PMC10954546
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Synthetic PET from CT improves diagnosis and prognosis for lung cancer: Proof of concept.
Salehjahromi M, Karpinets TV, Sujit SJ, Qayati M, Chen P, Aminu M, Saad MB, Bandyopadhyay R, Hong L, Sheshadri A, Lin J, Antonoff MB, Sepesi B, Ostrin EJ, Toumazis I, Huang P, Cheng C, Cascone T, Vokes NI, [...] Wu J
Cell Rep Med, 5(3):101463, 11 Mar 2024
Cited by: 2 articles | PMID: 38471502 | PMCID: PMC10983039
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Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial.
Besse B, Pons-Tostivint E, Park K, Hartl S, Forde PM, Hochmair MJ, Awad MM, Thomas M, Goss G, Wheatley-Price P, Shepherd FA, Florescu M, Cheema P, Chu QSC, Kim SW, Morgensztern D, Johnson ML, Cousin S, Kim DW, [...] Heymach JV
Nat Med, 30(3):716-729, 13 Feb 2024
Cited by: 3 articles | PMID: 38351187 | PMCID: PMC10957481
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