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Search life-sciences literature (45,103,589 articles, preprints and more)

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Targeting the tumour vasculature: from vessel destruction to promotion.
Guelfi S, Hodivala-Dilke K, Bergers G
Nat Rev Cancer, 24(10):655-675, 29 Aug 2024
Cited by: 0 articles | PMID: 39210063
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Treatment with αvβ3-integrin-specific 29P attenuates pressure-overload induced cardiac remodelling after transverse aortic constriction in mice.
Njegić A, Laid L, Zi M, Maniati E, Wang J, Chelu A, Wisniewski L, Hunter J, Prehar S, Stafford N, Gilon C, Hoffman A, Weinmüller M, Kessler H, Cartwright EJ, Hodivala-Dilke K
J Mol Cell Cardiol Plus, 8:100069, 01 Jun 2024
Cited by: 0 articles | PMID: 38933087 | PMCID: PMC11196926
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Effects of senescence on the tumour microenvironment and response to therapy.
Reynolds LE, Maallin S, Haston S, Martinez-Barbera JP, Hodivala-Dilke KM, Pedrosa AR
FEBS J, 291(11):2306-2319, 01 Nov 2023
Cited by: 3 articles | PMID: 37873605
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Author Correction: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.
Lechertier T, Reynolds LE, Kim H, Pedrosa AR, Gómez-Escudero J, Muñoz-Félix JM, Batista S, Dukinfield M, Demircioglu F, Wong PP, Matchett KP, Henderson NC, D'Amico G, Parsons M, Harwood C, Meier P, Hodivala-Dilke KM
Nat Commun, 14(1):5446, 06 Sep 2023
Cited by: 1 article | PMID: 37673931 | PMCID: PMC10482969
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Primary tumor-derived systemic nANGPTL4 inhibits metastasis.
Hübers C, Abdul Pari AA, Grieshober D, Petkov M, Schmidt A, Messmer T, Heyer CM, Schölch S, Kapel SS, Gengenbacher N, Singhal M, Schieb B, Fricke C, Will R, Remans K, Utikal JS, Reissfelder C, Schlesner M, Hodivala-Dilke KM, [...] Felcht M
J Exp Med, 220(1):e20202595, 21 Oct 2022
Cited by: 11 articles | PMID: 36269299 | PMCID: PMC9595206
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ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning.
D'Amico G, Fernandez I, Gómez-Escudero J, Kim H, Maniati E, Azman MS, Mardakheh FK, Serrels B, Serrels A, Parsons M, Squire A, Birdsey GM, Randi AM, Bolado-Carrancio A, Gangeswaran R, Reynolds LE, Bodrug N, Wang Y, Wang J, [...] Hodivala-Dilke KM
Development, 149(13):dev200528, 12 Jul 2022
Cited by: 2 articles | PMID: 35723257 | PMCID: PMC9340553
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Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment.
Roy-Luzarraga M, Reynolds LE, de Luxán-Delgado B, Maiques O, Wisniewski L, Newport E, Rajeeve V, Drake RJG, Gómez-Escudero J, Richards FM, Weller C, Dormann C, Meng YM, Vermeulen PB, Saur D, Sanz-Moreno V, Wong PP, Géraud C, Cutillas PR, Hodivala-Dilke K
Cancer Res, 82(10):1909-1925, 01 May 2022
Cited by: 12 articles | PMID: 35350066 | PMCID: PMC9381116
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Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion.
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A, Marshall JJT, Rosewell I, Tatari M, Rajeeve V, Khan F, Wang J, Kotantaki P, Tyler EJ, Singh N, Reader CS, Carter EP, [...] Cameron AJM
Cell Rep, 38(4):110227, 01 Jan 2022
Cited by: 30 articles | PMID: 35081338 | PMCID: PMC8810397
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Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth.
Newport E, Pedrosa AR, Lees D, Dukinfield M, Carter E, Gomez-Escudero J, Casado P, Rajeeve V, Reynolds LE, R Cutillas P, Duffy SW, De Luxán Delgado B, Hodivala-Dilke K
J Pathol, 256(2):235-247, 20 Dec 2021
Cited by: 7 articles | PMID: 34743335
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Improved Immunotherapy Efficacy by Vascular Modulation.
Newport EL, Pedrosa AR, Njegic A, Hodivala-Dilke KM, Muñoz-Félix JM
Cancers (Basel), 13(20):5207, 17 Oct 2021
Cited by: 9 articles | PMID: 34680355 | PMCID: PMC8533721
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Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice.
Delvecchio FR, Fincham REA, Spear S, Clear A, Roy-Luzarraga M, Balkwill FR, Gribben JG, Bombardieri M, Hodivala-Dilke K, Capasso M, Kocher HM
Cell Mol Gastroenterol Hepatol, 12(5):1543-1565, 09 Jul 2021
Cited by: 43 articles | PMID: 34252585 | PMCID: PMC8529396
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Correction to: Phosphorylation of pericyte FAK‑Y861 affects tumour cell apoptosis and tumour blood vessel regression.
Lees DM, Reynolds LE, Pedrosa AR, Roy-Luzarraga M, Hodivala-Dilke KM
Angiogenesis, 24(3):483-487, 01 Aug 2021
Cited by: 0 articles | PMID: 34218398 | PMCID: PMC8292262
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Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression.
Lees DM, Reynolds LE, Pedrosa AR, Roy-Luzarraga M, Hodivala-Dilke KM
Angiogenesis, 24(3):471-482, 17 Mar 2021
Cited by: 13 articles | PMID: 33730293 | PMCID: PMC8292267
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Association of Low Tumor Endothelial Cell pY397-Focal Adhesion Kinase Expression With Survival in Patients With Neoadjuvant-Treated Locally Advanced Breast Cancer.
Roy-Luzarraga M, Abdel-Fatah T, Reynolds LE, Clear A, Taylor JG, Gribben JG, Chan S, Jones L, Hodivala-Dilke K
JAMA Netw Open, 3(10):e2019304, 01 Oct 2020
Cited by: 5 articles | PMID: 33107920 | PMCID: PMC7592032
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Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.
Lechertier T, Reynolds LE, Kim H, Pedrosa AR, Gómez-Escudero J, Muñoz-Félix JM, Batista S, Dukinfield M, Demircioglu F, Wong PP, Matchett KP, Henderson NC, D'Amico G, Parsons M, Harwood C, Meier P, Hodivala-Dilke KM
Nat Commun, 11(1):2810, 04 Jun 2020
Cited by: 27 articles | PMID: 32499572 | PMCID: PMC7272651
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Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression
Lees DM, Reynolds LE, Pedrosa AR, Roy-Luzarraga M, Hodivala-Dilke KM
bioRxiv, 18 Jun 2020
Cited by: 0 articles | PPR: PPR177843
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Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells.
Wong PP, Muñoz-Félix JM, Hijazi M, Kim H, Robinson SD, De Luxán-Delgado B, Rodríguez-Hernández I, Maiques O, Meng YM, Meng Q, Bodrug N, Dukinfield MS, Reynolds LE, Elia G, Clear A, Harwood C, Wang Y, Campbell JJ, Singh R, [...] Hodivala-Dilke KM
Cell, 181(6):1346-1363.e21, 29 May 2020
Cited by: 43 articles | PMID: 32473126
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C-type natriuretic peptide co-ordinates cardiac structure and function.
Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS, Hobbs AJ
Eur Heart J, 41(9):1006-1020, 01 Mar 2020
Cited by: 41 articles | PMID: 30903134 | PMCID: PMC7068173
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Tumor Cell-Derived Angiopoietin-2 Promotes Metastasis in Melanoma.
Abdul Pari AA, Singhal M, Hübers C, Mogler C, Schieb B, Gampp A, Gengenbacher N, Reynolds LE, Terhardt D, Géraud C, Utikal J, Thomas M, Goerdt S, Hodivala-Dilke KM, Augustin HG, Felcht M
Cancer Res, 80(12):2586-2598, 17 Apr 2020
Cited by: 21 articles | PMID: 32303578 | PMCID: PMC7611175
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"Splitting the matrix": intussusceptive angiogenesis meets MT1-MMP.
D'Amico G, Muñoz-Félix JM, Pedrosa AR, Hodivala-Dilke KM
EMBO Mol Med, 12(2):e11663, 20 Dec 2019
Cited by: 11 articles | PMID: 31858727 | PMCID: PMC7005529
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Cancer associated fibroblast FAK regulates malignant cell metabolism.
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J, Newport E, Rajeeve V, Baker AM, Roy-Luzarraga M, Graham TA, Foster J, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, [...] Hodivala-Dilke K
Nat Commun, 11(1):1290, 10 Mar 2020
Cited by: 76 articles | PMID: 32157087 | PMCID: PMC7064590
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Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway.
Wilcz-Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Moreno Béjar R, Uhlik L, Bentham RB, Godinho SA, Dalli J, Grose R, Szabadkai G, Jones L, Hodivala-Dilke K, Bianchi K
EMBO Mol Med, 12(2):e10491, 13 Jan 2020
Cited by: 6 articles | PMID: 31930708 | PMCID: PMC7005540
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Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations.
Li J, Fukase Y, Shang Y, Zou W, Muñoz-Félix JM, Buitrago L, van Agthoven J, Zhang Y, Hara R, Tanaka Y, Okamoto R, Yasui T, Nakahata T, Imaeda T, Aso K, Zhou Y, Locuson C, Nesic D, Duggan M, [...] Coller BS
ACS Pharmacol Transl Sci, 2(6):387-401, 02 Aug 2019
Cited by: 18 articles | PMID: 32259072 | PMCID: PMC7088984
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Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease.
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J, Bedi KC, Margulies KB, Sanz-Moreno V, Hobbs A, Hodivala-Dilke K
J Pathol, 249(4):523-535, 30 Oct 2019
Cited by: 2 articles | PMID: 31424556 | PMCID: PMC6900130
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Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction.
Li Z, Solomonidis EG, Meloni M, Taylor RS, Duffin R, Dobie R, Magalhaes MS, Henderson BEP, Louwe PA, D'Amico G, Hodivala-Dilke KM, Shah AM, Mills NL, Simons BD, Gray GA, Henderson NC, Baker AH, Brittan M
Eur Heart J, 40(30):2507-2520, 01 Aug 2019
Cited by: 118 articles | PMID: 31162546 | PMCID: PMC6685329
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