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Search life-sciences literature (45,103,589 articles, preprints and more)

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Generation and characterization of B7-H4/B7S1/B7x-deficient mice.
Suh WK, Wang S, Duncan GS, Miyazaki Y, Cates E, Walker T, Gajewska BU, Deenick E, Dawicki W, Okada H, Wakeham A, Itie A, Watts TH, Ohashi PS, Jordana M, Yoshida H, Mak TW
Mol Cell Biol, 26(17):6403-6411, 01 Sep 2006
Cited by: 50 articles | PMID: 16914726 | PMCID: PMC1592821
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The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.
Suh WK, Gajewska BU, Okada H, Gronski MA, Bertram EM, Dawicki W, Duncan GS, Bukczynski J, Plyte S, Elia A, Wakeham A, Itie A, Chung S, Da Costa J, Arya S, Horan T, Campbell P, Gaida K, Ohashi PS, [...] Mak TW
Nat Immunol, 4(9):899-906, 17 Aug 2003
Cited by: 363 articles | PMID: 12925852
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Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).
Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK
Proc Natl Acad Sci U S A, 100(9):5431-5436, 17 Apr 2003
Cited by: 54 articles | PMID: 12702766 | PMCID: PMC154362
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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.
Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, Mirtsos C, Takada H, Wakeham A, Itie A, Li S, Penninger JM, Wesche H, Ohashi PS, Mak TW, Yeh WC
Nature, 416(6882):750-756, 31 Mar 2002
Cited by: 463 articles | PMID: 11923871
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Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo.
Liu Y, Snow BE, Hande MP, Baerlocher G, Kickhoefer VA, Yeung D, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L
Mol Cell Biol, 20(21):8178-8184, 01 Nov 2000
Cited by: 49 articles | PMID: 11027287 | PMCID: PMC86427
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The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.
Hara H, Takeda A, Takeuchi M, Wakeham AC, Itié A, Sasaki M, Mak TW, Yoshimura A, Nomoto K, Yoshida H
J Immunol, 168(5):2288-2295, 01 Mar 2002
Cited by: 31 articles | PMID: 11859117
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Generation and characterization of Smac/DIABLO-deficient mice.
Okada H, Suh WK, Jin J, Woo M, Du C, Elia A, Duncan GS, Wakeham A, Itie A, Lowe SW, Wang X, Mak TW
Mol Cell Biol, 22(10):3509-3517, 01 May 2002
Cited by: 116 articles | PMID: 11971981 | PMCID: PMC133802
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Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.
Yeh WC, Itie A, Elia AJ, Ng M, Shu HB, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel DV, Mak TW
Immunity, 12(6):633-642, 01 Jun 2000
Cited by: 327 articles | PMID: 10894163
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ICOS is essential for effective T-helper-cell responses.
Tafuri A, Shahinian A, Bladt F, Yoshinaga SK, Jordana M, Wakeham A, Boucher LM, Bouchard D, Chan VS, Duncan G, Odermatt B, Ho A, Itie A, Horan T, Whoriskey JS, Pawson T, Penninger JM, Ohashi PS, Mak TW
Nature, 409(6816):105-109, 01 Jan 2001
Cited by: 424 articles | PMID: 11343123
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The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.
Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L
Curr Biol, 10(22):1459-1462, 01 Nov 2000
Cited by: 169 articles | PMID: 11102810
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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.
Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM
Nature, 397(6717):315-323, 01 Jan 1999
Cited by: 1990 articles | PMID: 9950424
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Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.
Bonnard M, Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, Itié A, Wakeham A, Shahinian A, Henzel WJ, Elia AJ, Shillinglaw W, Mak TW, Cao Z, Yeh WC
EMBO J, 19(18):4976-4985, 01 Sep 2000
Cited by: 233 articles | PMID: 10990461 | PMCID: PMC314216
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Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma.
Elchebly M, Wagner J, Kennedy TE, Lanctôt C, Michaliszyn E, Itié A, Drouin J, Tremblay ML
Nat Genet, 21(3):330-333, 01 Mar 1999
Cited by: 112 articles | PMID: 10080191
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Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.
Sirard C, Kim S, Mirtsos C, Tadich P, Hoodless PA, Itié A, Maxson R, Wrana JL, Mak TW
J Biol Chem, 275(3):2063-2070, 01 Jan 2000
Cited by: 94 articles | PMID: 10636910
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Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM
Science, 287(5455):1040-1046, 01 Feb 2000
Cited by: 676 articles | PMID: 10669416
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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.
Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, Oliveira-dos-Santos A, Mariathasan S, Bouchard D, Wakeham A, Itie A, Le J, Ohashi PS, Sarosi I, Nishina H, Lipkowitz S, Penninger JM
Nature, 403(6766):211-216, 01 Jan 2000
Cited by: 449 articles | PMID: 10646608
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SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival.
Liu Q, Sasaki T, Kozieradzki I, Wakeham A, Itie A, Dumont DJ, Penninger JM
Genes Dev, 13(7):786-791, 01 Apr 1999
Cited by: 206 articles | PMID: 10197978 | PMCID: PMC316591
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Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells.
Kapp U, Yeh WC, Patterson B, Elia AJ, Kägi D, Ho A, Hessel A, Tipsword M, Williams A, Mirtsos C, Itie A, Moyle M, Mak TW
J Exp Med, 189(12):1939-1946, 01 Jun 1999
Cited by: 147 articles | PMID: 10377189 | PMCID: PMC2192965
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, Morony S, Capparelli C, Van G, Kaufman S, van der Heiden A, Itie A, Wakeham A, Khoo W, Sasaki T, Cao Z, Penninger JM, Paige CJ, Lacey DL, [...] Mak TW
Genes Dev, 13(8):1015-1024, 01 Apr 1999
Cited by: 780 articles | PMID: 10215628 | PMCID: PMC316636
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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M, Mak TW
Curr Biol, 8(21):1169-1178, 01 Oct 1998
Cited by: 505 articles | PMID: 9799734
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The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.
Sirard C, de la Pompa JL, Elia A, Itie A, Mirtsos C, Cheung A, Hahn S, Wakeham A, Schwartz L, Kern SE, Rossant J, Mak TW
Genes Dev, 12(1):107-119, 01 Jan 1998
Cited by: 311 articles | PMID: 9420335 | PMCID: PMC316400
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Increased expression of proopiomelanocortin (POMC) mRNA in adrenal glands of mice undergoing graft-versus-host disease (GVHD): association with persistent elevated plasma corticosterone levels.
You-Ten KE, Itié A, Seemayer TA, Palfree RG, Lapp WS
Clin Exp Immunol, 102(3):596-602, 01 Dec 1995
Cited by: 4 articles | PMID: 8536378
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Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice.
You-Ten KE, Muise ES, Itié A, Michaliszyn E, Wagner J, Jothy S, Lapp WS, Tremblay ML
J Exp Med, 186(5):683-693, 01 Aug 1997
Cited by: 219 articles | PMID: 9271584 | PMCID: PMC2199020
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Brca2 is required for embryonic cellular proliferation in the mouse.
Suzuki A, de la Pompa JL, Hakem R, Elia A, Yoshida R, Mo R, Nishina H, Chuang T, Wakeham A, Itie A, Koo W, Billia P, Ho A, Fukumoto M, Hui CC, Mak TW
Genes Dev, 11(10):1242-1252, 01 May 1997
Cited by: 181 articles | PMID: 9171369
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