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Search life-sciences literature (45,105,671 articles, preprints and more)

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Evaluation of Alpha-Synuclein and Tau Antiaggregation Activity of Urea and Thiourea-Based Small Molecules for Neurodegenerative Disease Therapeutics.
Ganegamage SK, Ademoye TA, Patel H, Alnakhala H, Tripathi A, Nguyen CCD, Pham K, Plascencia-Villa G, Zhu X, Perry G, Tian S, Dettmer U, Lasagna-Reeves C, Fortin JS
ACS Chem Neurosci, 15(21):3915-3931, 22 Oct 2024
Cited by: 0 articles | PMID: 39436010
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TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model.
Kim J, Tadros B, Liang YH, Kim Y, Lasagna-Reeves C, Sonn JY, Chung DC, Hyman B, Holtzman DM, Zoghbi HY
Nat Neurosci, 11 Nov 2024
Cited by: 0 articles | PMID: 39528671
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Deletion of miR-33, a regulator of the ABCA1-APOE pathway, ameliorates neuropathological phenotypes in APP/PS1 mice.
Tate M, Wijeratne HRS, Kim B, Philtjens S, You Y, Lee DH, Gutierrez DA, Sharify D, Wells M, Perez-Cardelo M, Doud EH, Fernandez-Hernando C, Lasagna-Reeves C, Mosley AL, Kim J
Alzheimers Dement, 20(11):7805-7818, 30 Sep 2024
Cited by: 0 articles | PMID: 39345217 | PMCID: PMC11567857
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Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer's progression.
Codocedo JF, Mera-Reina C, Bor-Chian Lin P, Fallen PB, Puntambekar SS, Casali BT, Jury-Garfe N, Martinez P, Lasagna-Reeves CA, Landreth GE
Cell Rep, 43(7):114488, 13 Jul 2024
Cited by: 0 articles | PMID: 39002124 | PMCID: PMC11398604
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Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer's disease.
Jury-Garfe N, Redding-Ochoa J, You Y, Martínez P, Karahan H, Chimal-Juárez E, Johnson TS, Zhang J, Resnick S, Kim J, Troncoso JC, Lasagna-Reeves CA
Acta Neuropathol, 148(1):15, 05 Aug 2024
Cited by: 1 article | PMID: 39102080 | PMCID: PMC11300572
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Protocol for the isolation and proteomic analysis of pathological tau-seeds.
Martinez P, Patel H, You Y, Doud EH, Mosley AL, Lasagna-Reeves CA
STAR Protoc, 5(3):103185, 29 Jul 2024
Cited by: 0 articles | PMID: 39078738 | PMCID: PMC11333924
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Phosphorylation at serine 214 correlates with tau seeding activity in an age-dependent manner in two mouse models for tauopathies and is required for tau transsynaptic propagation
Martinez P, Jury-Garfe N, Patel H, You Y, Perkins A, You Y, Lee-Gosselin A, Vidal R, Lasagna-Reeves CA
bioRxiv, 23 Jul 2024
Cited by: 0 articles | PPR: PPR886384
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Loss of Inpp5d has disease-relevant and sex-specific effects on glial transcriptomes.
Dabin LC, Kersey H, Kim B, Acri DJ, Sharify D, Lee-Gosselin A, Lasagna-Reeves CA, Oblak AL, Lamb BT, Kim J
Alzheimers Dement, 20(8):5311-5323, 26 Jun 2024
Cited by: 1 article | PMID: 38923164 | PMCID: PMC11350029
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Therapeutic targeting of immunometabolism in Alzheimer’s disease reveals a critical reliance on Hexokinase 2 dosage on microglial activation and disease progression
Codocedo JF, Mera-Reina C, Lin PB, Puntambekar SS, Casali BT, Jury N, Martinez P, Lasagna-Reeves CA, Landreth GE
bioRxiv, 15 Nov 2023
Cited by: 0 articles | PPR: PPR759551
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Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation.
Ramirez E, Ganegamage SK, Min S, Patel H, Ogunware A, Plascencia-Villa G, Alnakhala H, Shimanaka K, Tripathi A, Wang KW, Zhu X, Rochet JC, Kuo MH, Counts SE, Perry G, Dettmer U, Lasagna-Reeves CA, Fortin JS
ACS Chem Neurosci, 14(21):3913-3927, 11 Oct 2023
Cited by: 0 articles | PMID: 37818657 | PMCID: PMC10624178
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Network analysis identifies strain-dependent response to tau and tau seeding-associated genes.
Acri DJ, You Y, Tate MD, Karahan H, Martinez P, McCord B, Sharify AD, John S, Kim B, Dabin LC, Philtjens S, Wijeratne HRS, McCray TJ, Smith DC, Bissel SJ, Lamb BT, Lasagna-Reeves CA, Kim J
J Exp Med, 220(11):e20230180, 22 Aug 2023
Cited by: 1 article | PMID: 37606887 | PMCID: PMC10443211
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Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer’s disease
Jury-Garfe N, You Y, Martínez P, Redding-Ochoa J, Karahan H, Johnson TS, Zhang J, Kim J, Troncoso JC, Lasagna-Reeves CA
bioRxiv, 28 Jul 2023
Cited by: 0 articles | PPR: PPR699030
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TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo.
Lee-Gosselin A, Jury-Garfe N, You Y, Dabin L, Soni D, Dutta S, Rochet JC, Kim J, Oblak AL, Lasagna-Reeves CA
Cells, 12(12):1597, 10 Jun 2023
Cited by: 6 articles | PMID: 37371067 | PMCID: PMC10296847
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TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation.
Moutinho M, Coronel I, Tsai AP, Di Prisco GV, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, Landreth GE
Genome Med, 15(1):11, 20 Feb 2023
Cited by: 10 articles | PMID: 36805764 | PMCID: PMC9940368
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Network analysis reveals strain-dependent response to misfolded tau aggregates
Acri DJ, You Y, Tate MD, McCord B, Sharify AD, John S, Karahan H, Kim B, Dabin LC, Philtjens S, Wijeratne HS, McCray TJ, Smith DC, Bissel SJ, Lamb BT, Lasagna-Reeves CA, Kim J
bioRxiv, 30 Jan 2023
Cited by: 0 articles | PPR: PPR610033
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Bassoon contributes to tau-seed propagation and neurotoxicity.
Martinez P, Patel H, You Y, Jury N, Perkins A, Lee-Gosselin A, Taylor X, You Y, Viana Di Prisco G, Huang X, Dutta S, Wijeratne AB, Redding-Ochoa J, Shahid SS, Codocedo JF, Min S, Landreth GE, Mosley AL, Wu YC, [...] Lasagna-Reeves CA
Nat Neurosci, 25(12):1597-1607, 07 Nov 2022
Cited by: 20 articles | PMID: 36344699 | PMCID: PMC9708566
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The reduction of astrocytic tau prevents amyloid-β-induced synaptotoxicity.
Cisternas P, Taylor X, Martinez P, Maldonado O, Jury N, Lasagna-Reeves CA
Brain Commun, 4(5):fcac235, 19 Sep 2022
Cited by: 3 articles | PMID: 36196088 | PMCID: PMC9527666
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CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer's disease.
Puntambekar SS, Moutinho M, Lin PB, Jadhav V, Tumbleson-Brink D, Balaji A, Benito MA, Xu G, Oblak A, Lasagna-Reeves CA, Landreth GE, Lamb BT
Mol Neurodegener, 17(1):47, 28 Jun 2022
Cited by: 38 articles | PMID: 35764973 | PMCID: PMC9241248
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The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.
Moutinho M, Puntambekar SS, Tsai AP, Coronel I, Lin PB, Casali BT, Martinez P, Oblak AL, Lasagna-Reeves CA, Lamb BT, Landreth GE
Sci Transl Med, 14(637):eabl7634, 23 Mar 2022
Cited by: 29 articles | PMID: 35320002 | PMCID: PMC10161396
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Activated endothelial cells induce a distinct type of astrocytic reactivity.
Taylor X, Cisternas P, Jury N, Martinez P, Huang X, You Y, Redding-Ochoa J, Vidal R, Zhang J, Troncoso J, Lasagna-Reeves CA
Commun Biol, 5(1):282, 29 Mar 2022
Cited by: 18 articles | PMID: 35351973 | PMCID: PMC8964703
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Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathy.
Patel H, Martinez P, Perkins A, Taylor X, Jury N, McKinzie D, Lasagna-Reeves CA
Neurobiol Aging, 109:52-63, 20 Sep 2021
Cited by: 15 articles | PMID: 34655981 | PMCID: PMC8671336
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Vascular amyloid accumulation alters the gabaergic synapse and induces hyperactivity in a model of cerebral amyloid angiopathy.
Cisternas P, Taylor X, Perkins A, Maldonado O, Allman E, Cordova R, Marambio Y, Munoz B, Pennington T, Xiang S, Zhang J, Vidal R, Atwood B, Lasagna-Reeves CA
Aging Cell, 19(10):e13233, 10 Sep 2020
Cited by: 9 articles | PMID: 32914559 | PMCID: PMC7576303
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A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy.
Taylor X, Cisternas P, You Y, You Y, Xiang S, Marambio Y, Zhang J, Vidal R, Lasagna-Reeves CA
J Neuroinflammation, 17(1):223, 25 Jul 2020
Cited by: 29 articles | PMID: 32711525 | PMCID: PMC7382050
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The Amyloid-Tau-Neuroinflammation Axis in the Context of Cerebral Amyloid Angiopathy.
Cisternas P, Taylor X, Lasagna-Reeves CA
Int J Mol Sci, 20(24):E6319, 14 Dec 2019
Cited by: 20 articles | PMID: 31847365 | PMCID: PMC6941131
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Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy.
You Y, Perkins A, Cisternas P, Muñoz B, Taylor X, You Y, Garringer HJ, Oblak AL, Atwood BK, Vidal R, Lasagna-Reeves CA
Acta Neuropathol Commun, 7(1):26, 26 Feb 2019
Cited by: 21 articles | PMID: 30808415 | PMCID: PMC6390363
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