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Search life-sciences literature (45,103,589 articles, preprints and more)

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Is there a single porcine protegrin gene?
Lehrer RI
FEBS J, 281(24):5418-5419, 26 Nov 2014
Cited by: 0 articles | PMID: 25387882
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Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.
Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL
Science, 337(6093):477-481, 21 Jun 2012
Cited by: 220 articles | PMID: 22722251 | PMCID: PMC4332406
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θ-Defensins: cyclic peptides with endless potential.
Lehrer RI, Cole AM, Selsted ME
J Biol Chem, 287(32):27014-27019, 14 Jun 2012
Cited by: 86 articles | PMID: 22700960 | PMCID: PMC3411038
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Hapivirins and diprovirins: novel θ-defensin analogs with potent activity against influenza A virus.
Doss M, Ruchala P, Tecle T, Gantz D, Verma A, Hartshorn A, Crouch EC, Luong H, Micewicz ED, Lehrer RI, Hartshorn KL
J Immunol, 188(6):2759-2768, 15 Feb 2012
Cited by: 25 articles | PMID: 22345650 | PMCID: PMC3294087
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α-Defensins in human innate immunity.
Lehrer RI, Lu W
Immunol Rev, 245(1):84-112, 01 Jan 2012
Cited by: 239 articles | PMID: 22168415
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Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide.
Pazgier M, Wei G, Ericksen B, Jung G, Wu Z, de Leeuw E, Yuan W, Szmacinski H, Lu WY, Lubkowski J, Lehrer RI, Lu W
J Biol Chem, 287(12):8944-8953, 23 Jan 2012
Cited by: 36 articles | PMID: 22270360 | PMCID: PMC3308808
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Humanized theta-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections.
Welkos S, Cote CK, Hahn U, Shastak O, Jedermann J, Bozue J, Jung G, Ruchala P, Pratikhya P, Tang T, Lehrer RI, Beyer W
Antimicrob Agents Chemother, 55(9):4238-4250, 18 Jul 2011
Cited by: 41 articles | PMID: 21768520 | PMCID: PMC3165295
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The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques.
Cole AM, Patton DL, Rohan LC, Cole AL, Cosgrove-Sweeney Y, Rogers NA, Ratner D, Sassi AB, Lackman-Smith C, Tarwater P, Ramratnam B, Ruchala P, Lehrer RI, Waring AJ, Gupta P
PLoS One, 5(11):e15111, 29 Nov 2010
Cited by: 35 articles | PMID: 21124745 | PMCID: PMC2993972
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Immunology: Peptide gets in shape for self-defence.
Lehrer RI
Nature, 469(7330):309-310, 01 Jan 2011
Cited by: 12 articles | PMID: 21248835
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Defensins enable macrophages to inhibit the intracellular proliferation of Listeria monocytogenes.
Arnett E, Lehrer RI, Pratikhya P, Lu W, Seveau S
Cell Microbiol, 13(4):635-651, 13 Jan 2011
Cited by: 39 articles | PMID: 21143570
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Inerolysin, a cholesterol-dependent cytolysin produced by Lactobacillus iners.
Rampersaud R, Planet PJ, Randis TM, Kulkarni R, Aguilar JL, Lehrer RI, Ratner AJ
J Bacteriol, 193(5):1034-1041, 17 Dec 2010
Cited by: 92 articles | PMID: 21169489 | PMCID: PMC3067590
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Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids.
Ruchala P, Navab M, Jung CL, Hama-Levy S, Micewicz ED, Luong H, Reyles JE, Sharma S, Waring AJ, Fogelman AM, Lehrer RI
PLoS One, 5(4):e10181, 14 Apr 2010
Cited by: 5 articles | PMID: 20418958 | PMCID: PMC2854715
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Trp-26 imparts functional versatility to human alpha-defensin HNP1.
Wei G, Pazgier M, de Leeuw E, Rajabi M, Li J, Zou G, Jung G, Yuan W, Lu WY, Lehrer RI, Lu W
J Biol Chem, 285(21):16275-16285, 10 Mar 2010
Cited by: 40 articles | PMID: 20220136 | PMCID: PMC2871495
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De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry.
Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R
Rapid Commun Mass Spectrom, 24(5):599-604, 01 Mar 2010
Cited by: 9 articles | PMID: 20155756
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Antimicrobial mechanism of pore-forming protegrin peptides: 100 pores to kill E. coli.
Bolintineanu D, Hazrati E, Davis HT, Lehrer RI, Kaznessis YN
Peptides, 31(1):1-8, 30 Nov 2009
Cited by: 42 articles | PMID: 19931583 | PMCID: PMC2825693
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Through the looking glass, mechanistic insights from enantiomeric human defensins.
Wei G, de Leeuw E, Pazgier M, Yuan W, Zou G, Wang J, Ericksen B, Lu WY, Lehrer RI, Lu W
J Biol Chem, 284(42):29180-29192, 29 Jul 2009
Cited by: 74 articles | PMID: 19640840 | PMCID: PMC2781462
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Antimicrobial host defense peptides in an arteriviral infection: differential peptide expression and virus inactivation.
Sang Y, Ruchala P, Lehrer RI, Ross CR, Rowland RR, Blecha F
Viral Immunol, 22(4):235-242, 01 Jul 2009
Cited by: 16 articles | PMID: 19594394
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Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins.
Lehrer RI, Jung G, Ruchala P, Wang W, Micewicz ED, Waring AJ, Gillespie EJ, Bradley KA, Ratner AJ, Rest RF, Lu W
Infect Immun, 77(9):4028-4040, 06 Jul 2009
Cited by: 32 articles | PMID: 19581399 | PMCID: PMC2738040
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Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D.
Doss M, White MR, Tecle T, Gantz D, Crouch EC, Jung G, Ruchala P, Waring AJ, Lehrer RI, Hartshorn KL
J Immunol, 182(12):7878-7887, 01 Jun 2009
Cited by: 90 articles | PMID: 19494312
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Multivalent binding of carbohydrates by the human alpha-defensin, HD5.
Lehrer RI, Jung G, Ruchala P, Andre S, Gabius HJ, Lu W
J Immunol, 183(1):480-490, 01 Jul 2009
Cited by: 58 articles | PMID: 19542459
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Retrocyclin-2: a potent anti-HIV theta-defensin that forms a cyclic cystine ladder structural motif.
Daly NL, Chen YK, Rosengren KJ, Marx UC, Phillips ML, Waring AJ, Wang W, Lehrer RI, Craik DJ
Adv Exp Med Biol, 611:577-578, 01 Jan 2009
Cited by: 3 articles | PMID: 19400321
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Reawakening retrocyclins: ancestral human defensins active against HIV-1.
Venkataraman N, Cole AL, Ruchala P, Waring AJ, Lehrer RI, Stuchlik O, Pohl J, Cole AM
PLoS Biol, 7(4):e95, 01 Apr 2009
Cited by: 56 articles | PMID: 19402752 | PMCID: PMC2672613
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A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.
Navab M, Ruchala P, Waring AJ, Lehrer RI, Hama S, Hough G, Palgunachari MN, Anantharamaiah GM, Fogelman AM
J Lipid Res, 50(8):1538-1547, 18 Feb 2009
Cited by: 43 articles | PMID: 19225094 | PMCID: PMC2724044
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Induction of group A Streptococcus virulence by a human antimicrobial peptide.
Gryllos I, Tran-Winkler HJ, Cheng MF, Chung H, Bolcome R, Lu W, Lehrer RI, Wessels MR
Proc Natl Acad Sci U S A, 105(43):16755-16760, 20 Oct 2008
Cited by: 89 articles | PMID: 18936485 | PMCID: PMC2575492
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Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I.
Van Lenten BJ, Wagner AC, Jung CL, Ruchala P, Waring AJ, Lehrer RI, Watson AD, Hama S, Navab M, Anantharamaiah GM, Fogelman AM
J Lipid Res, 49(11):2302-2311, 11 Jul 2008
Cited by: 131 articles | PMID: 18621920 | PMCID: PMC2563211
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