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Search life-sciences literature (45,104,145 articles, preprints and more)

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Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired.
Liang W, Sagar S, Ravindran R, Najor RH, Quiles JM, Chi L, Diao RY, Woodall BP, Leon LJ, Zumaya E, Duran J, Cauvi DM, De Maio A, Adler ED, Gustafsson ÅB
Nat Commun, 14(1):5031, 18 Aug 2023
Cited by: 34 articles | PMID: 37596294 | PMCID: PMC10439183
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The Small GTPase Rab7 Regulates Release of Mitochondria in Extracellular Vesicles in Response to Lysosomal Dysfunction
Liang W, Diao RY, Quiles JM, Najor RH, Chi L, Woodall BP, Leon LJ, Duran J, Cauvi DM, De Maio A, Adler ED, Gustafsson ÅB
bioRxiv, 13 Feb 2023
Cited by: 0 articles | PPR: PPR615744
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Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy.
Zhu S, Chen Z, Zhu M, Shen Y, Leon LJ, Chi L, Spinozzi S, Tan C, Gu Y, Nguyen A, Zhou Y, Feng W, Vaz FM, Wang X, Gustafsson AB, Evans SM, Kunfu O, Fang X
Circ Heart Fail, 14(6):e008289, 15 Jun 2021
Cited by: 24 articles | PMID: 34129362 | PMCID: PMC8210459
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Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise.
Moyzis AG, Lally NS, Liang W, Leon LJ, Najor RH, Orogo AM, Gustafsson ÅB
J Mol Cell Cardiol, 146:109-120, 25 Jul 2020
Cited by: 14 articles | PMID: 32717194 | PMCID: PMC7494655
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Nuclear Parkin Activates the ERRα Transcriptional Program and Drives Widespread Changes in Gene Expression Following Hypoxia.
Shires SE, Quiles JM, Najor RH, Leon LJ, Cortez MQ, Lampert MA, Mark A, Gustafsson ÅB
Sci Rep, 10(1):8499, 22 May 2020
Cited by: 10 articles | PMID: 32444656 | PMCID: PMC7244578
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Family history of pre-eclampsia and cardiovascular disease as risk factors for pre-eclampsia: the GenPE case-control study.
Serrano NC, Quintero-Lesmes DC, Dudbridge F, Leon LJ, Hingorani AD, Williams DJ, Casas JP
Hypertens Pregnancy, 39(1):56-63, 07 Jan 2020
Cited by: 7 articles | PMID: 31910697
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Preeclampsia and Cardiovascular Disease in a Large UK Pregnancy Cohort of Linked Electronic Health Records: A CALIBER Study.
Leon LJ, McCarthy FP, Direk K, Gonzalez-Izquierdo A, Prieto-Merino D, Casas JP, Chappell L
Circulation, 140(13):1050-1060, 23 Sep 2019
Cited by: 113 articles | PMID: 31545680
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BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation.
Lampert MA, Orogo AM, Najor RH, Hammerling BC, Leon LJ, Wang BJ, Kim T, Sussman MA, Gustafsson ÅB
Autophagy, 15(7):1182-1198, 22 Feb 2019
Cited by: 150 articles | PMID: 30741592 | PMCID: PMC6613840
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Lipid profile, plasma apolipoproteins, and pre-eclampsia risk in the GenPE case-control study.
Serrano NC, Guio-Mahecha E, Quintero-Lesmes DC, Becerra-Bayona S, Paez MC, Beltran M, Herrera VM, Leon LJ, Williams D, Casas JP
Atherosclerosis, 276:189-194, 04 Jun 2018
Cited by: 24 articles | PMID: 29914672
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Enrichment of Clinically Relevant Organisms in Spontaneous Preterm-Delivered Placentas and Reagent Contamination across All Clinical Groups in a Large Pregnancy Cohort in the United Kingdom.
Leon LJ, Doyle R, Diez-Benavente E, Clark TG, Klein N, Stanier P, Moore GE
Appl Environ Microbiol, 84(14):e00483-18, 02 Jul 2018
Cited by: 40 articles | PMID: 29776928 | PMCID: PMC6029081
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Genetic Analyses in Small-for-Gestational-Age Newborns.
Stalman SE, Solanky N, Ishida M, Alemán-Charlet C, Abu-Amero S, Alders M, Alvizi L, Baird W, Demetriou C, Henneman P, James C, Knegt LC, Leon LJ, Mannens MMAM, Mul AN, Nibbering NA, Peskett E, Rezwan FI, Ris-Stalpers C, [...] Hennekam RC
J Clin Endocrinol Metab, 103(3):917-925, 01 Mar 2018
Cited by: 21 articles | PMID: 29342293
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Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin.
Hammerling BC, Shires SE, Leon LJ, Cortez MQ, Gustafsson ÅB
Small GTPases, 11(1):69-76, 18 Sep 2017
Cited by: 20 articles | PMID: 28696827 | PMCID: PMC6959301
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A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance.
Hammerling BC, Najor RH, Cortez MQ, Shires SE, Leon LJ, Gonzalez ER, Boassa D, Phan S, Thor A, Jimenez RE, Li H, Kitsis RN, Dorn GW, Sadoshima J, Ellisman MH, Gustafsson ÅB
Nat Commun, 8:14050, 30 Jan 2017
Cited by: 100 articles | PMID: 28134239 | PMCID: PMC5290275
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Placental infection and maternal immunity in the Baby Bio Bank
Leon LJ
University College London (University of London), 01 Jan 2017
Cited by: 0 articles | ETH: 790798
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Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening.
Wu CY, Wang DH, Wang X, Dixon SM, Meng L, Ahadi S, Enter DH, Chen CY, Kato J, Leon LJ, Ramirez LM, Maeda Y, Reis CF, Ribeiro B, Weems B, Kung HJ, Lam KS
ACS Comb Sci, 18(6):320-329, 03 May 2016
Cited by: 6 articles | PMID: 27053324 | PMCID: PMC4908505
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Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells.
Rowson-Hodel AR, Berg AL, Wald JH, Hatakeyama J, VanderVorst K, Curiel DA, Leon LJ, Sweeney C, Carraway KL
Cancer Lett, 375(1):62-72, 02 Mar 2016
Cited by: 20 articles | PMID: 26944316 | PMCID: PMC5554595
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A new biological and clinical resource for research into pregnancy complications: The Baby Bio Bank.
Leon LJ, Solanky N, Stalman SE, Demetriou C, Abu-Amero S, Stanier P, Regan L, Moore GE
Placenta, 46:31-37, 24 Aug 2016
Cited by: 8 articles | PMID: 27697219 | PMCID: PMC5062948
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The role and interaction of imprinted genes in human fetal growth.
Moore GE, Ishida M, Demetriou C, Al-Olabi L, Leon LJ, Thomas AC, Abu-Amero S, Frost JM, Stafford JL, Chaoqun Y, Duncan AJ, Baigel R, Brimioulle M, Iglesias-Platas I, Apostolidou S, Aggarwal R, Whittaker JC, Syngelaki A, Nicolaides KH, [...] Stanier P
Philos Trans R Soc Lond B Biol Sci, 370(1663):20140074, 01 Mar 2015
Cited by: 81 articles | PMID: 25602077 | PMCID: PMC4305174
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Staying young at heart: autophagy and adaptation to cardiac aging.
Leon LJ, Gustafsson ÅB
J Mol Cell Cardiol, 95:78-85, 05 Nov 2015
Cited by: 25 articles | PMID: 26549356 | PMCID: PMC4860161
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Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB.
Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD
Anticancer Drugs, 25(4):433-446, 01 Apr 2014
Cited by: 1 article | PMID: 24525589 | PMCID: PMC3947856
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Paternally expressed, imprinted insulin-like growth factor-2 in chorionic villi correlates significantly with birth weight.
Demetriou C, Abu-Amero S, Thomas AC, Ishida M, Aggarwal R, Al-Olabi L, Leon LJ, Stafford JL, Syngelaki A, Peebles D, Nicolaides KH, Regan L, Stanier P, Moore GE
PLoS One, 9(1):e85454, 15 Jan 2014
Cited by: 27 articles | PMID: 24454871 | PMCID: PMC3893199
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Defibrillation success is not associated with near field electrogram complexity or shock timing.
Vigmond EJ, Kimber S, Suzuki G, Faris P, Leon LJ
Can J Cardiol, 29(9):1126-1133, 21 Feb 2013
Cited by: 1 article | PMID: 23434053
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A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells.
Leon LJ, Pasupuleti N, Gorin F, Carraway KL
PLoS One, 8(4):e63038, 30 Apr 2013
Cited by: 18 articles | PMID: 23646172 | PMCID: PMC3639988
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Selective attachment of F-actin with controlled length for developing an intelligent nanodevice.
Wei MY, Leon LJ, Lee Y, Parks D, Carroll L, Famouri P
J Colloid Interface Sci, 356(1):182-189, 03 Jan 2011
Cited by: 3 articles | PMID: 21269638
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Predicting defibrillation outcome based on phase of ventricular activity during ICD implantation.
Suzuki G, Leon LJ, Kimber S, Vigmond EJ
Annu Int Conf IEEE Eng Med Biol Soc, 2009:4759-4762, 01 Jan 2009
Cited by: 0 articles | PMID: 19964845
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