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Search life-sciences literature (45,104,206 articles, preprints and more)

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The Ashkenazi-Centric G334R Variant of <i>TP53</i> is Severely Impaired for Transactivation but Retains Tumor Suppressor Function in a Mouse Model.
Stieg DC, Casey K, Karisetty BC, Leu JI, Larkin F, Vogel P, Madzo J, Murphy ME
Mol Cell Biol, 1-15, 08 Nov 2024
Cited by: 0 articles | PMID: 39520074
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Deciphering the impact of genomic variation on function.
IGVF Consortium
Nature, 633(8028):47-57, 04 Sep 2024
Cited by: 3 articles | PMID: 39232149
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An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Indeglia A, Leung JC, Miller SA, Leu JI, Dougherty JF, Clarke NL, Kirven NA, Shao C, Ke L, Lovell S, Barnoud T, Lu DY, Lin C, Kannan T, Battaile KP, Yang THL, Batista Oliva I, Claiborne DT, Vogel P, [...] Murphy ME
Cancer Discov, 13(7):1696-1719, 01 Jul 2023
Cited by: 6 articles | PMID: 37140445 | PMCID: PMC10326602
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Common activities and predictive gene signature identified for genetic hypomorphs of TP53.
Leung JC, Leu JI, Indeglia A, Kannan T, Clarke NL, Kirven NA, Dweep H, Garlick D, Barnoud T, Kossenkov AV, George DL, Murphy ME
Proc Natl Acad Sci U S A, 120(7):e2212940120, 07 Feb 2023
Cited by: 5 articles | PMID: 36749725 | PMCID: PMC9962931
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Targeting ErbB3 and Cellular NADPH/NADP⁺ Abundance Sensitizes Cutaneous Melanomas to Ferroptosis Inducers.
Leu JI, Murphy ME, George DL
ACS Chem Biol, 17(5):1038-1044, 14 Apr 2022
Cited by: 5 articles | PMID: 35420772 | PMCID: PMC9208338
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HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS-mutant melanoma.
Parris JLD, Barnoud T, Leu JI, Leung JC, Ma W, Kirven NA, Poli ANR, Kossenkov AV, Liu Q, Salvino JM, George DL, Weeraratna AT, Chen Q, Murphy ME
Cancer Res Commun, 1(1):17-29, 01 Oct 2021
Cited by: 2 articles | PMID: 35187538 | PMCID: PMC8849551
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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser.
Gnanapradeepan K, Leu JI, Basu S, Barnoud T, Good M, Lee JV, Quinn WJ, Kung CP, Ahima R, Baur JA, Wellen KE, Liu Q, Schug ZT, George DL, Murphy ME
Elife, 9:e55994, 10 Nov 2020
Cited by: 10 articles | PMID: 33170774 | PMCID: PMC7661039
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P53 regulates cellular redox state, ferroptosis and metabolism.
Leu JI, Murphy ME, George DL
Mol Cell Oncol, 8(2):1877076, 08 Feb 2021
Cited by: 1 article | PMID: 33860080 | PMCID: PMC8018455
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Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53.
Leu JI, Murphy ME, George DL
Proc Natl Acad Sci U S A, 117(43):26804-26811, 14 Oct 2020
Cited by: 29 articles | PMID: 33055209 | PMCID: PMC7604449
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A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors.
Barnoud T, Leung JC, Leu JI, Basu S, Poli ANR, Parris JLD, Indeglia A, Martynyuk T, Good M, Gnanapradeepan K, Sanseviero E, Moeller R, Tang HY, Cassel J, Kossenkov AV, Liu Q, Speicher DW, Gabrilovich DI, Salvino JM, [...] Murphy ME
Cancer Res, 80(23):5270-5281, 06 Oct 2020
Cited by: 12 articles | PMID: 33023943 | PMCID: PMC7718317
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Author Correction: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.
Singh KS, Leu JI, Barnoud T, Vonteddu P, Gnanapradeepan K, Lin C, Liu Q, Barton JC, Kossenkov AV, George DL, Murphy ME, Dotiwala F
Nat Commun, 11(1):1541, 19 Mar 2020
Cited by: 2 articles | PMID: 32193389 | PMCID: PMC7081187
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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
Gnanapradeepan K, Basu S, Barnoud T, Leu JI, Good M, Lee JV, Quinn WJ, Kung C, Ahima RS, Baur JA, Wellen KE, Liu Q, Schug ZT, George DL, Murphy ME
bioRxiv, 15 Feb 2020
Cited by: 0 articles | PPR: PPR113279
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African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.
Singh KS, Leu JI, Barnoud T, Vonteddu P, Gnanapradeepan K, Lin C, Liu Q, Barton JC, Kossenkov AV, George DL, Murphy ME, Dotiwala F
Nat Commun, 11(1):473, 24 Jan 2020
Cited by: 25 articles | PMID: 31980600 | PMCID: PMC6981190
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Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53.
Leu JI, Murphy ME, George DL
Proc Natl Acad Sci U S A, 116(17):8390-8396, 08 Apr 2019
Cited by: 64 articles | PMID: 30962386 | PMCID: PMC6486733
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Tailoring Chemotherapy for the African-Centric S47 Variant of TP53.
Barnoud T, Budina-Kolomets A, Basu S, Leu JI, Good M, Kung CP, Liu J, Liu Q, Villanueva J, Zhang R, George DL, Murphy ME
Cancer Res, 78(19):5694-5705, 16 Aug 2018
Cited by: 7 articles | PMID: 30115697 | PMCID: PMC6168343
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Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function.
Leu JI, Barnoud T, Zhang G, Tian T, Wei Z, Herlyn M, Murphy ME, George DL
Oncotarget, 8(28):45656-45669, 01 Jul 2017
Cited by: 18 articles | PMID: 28484090 | PMCID: PMC5542216
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The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction.
Kung CP, Leu JI, Basu S, Khaku S, Anokye-Danso F, Liu Q, George DL, Ahima RS, Murphy ME
Cell Rep, 14(10):2413-2425, 03 Mar 2016
Cited by: 73 articles | PMID: 26947067 | PMCID: PMC4926645
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HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.
Budina-Kolomets A, Webster MR, Leu JI, Jennis M, Krepler C, Guerrini A, Kossenkov AV, Xu W, Karakousis G, Schuchter L, Amaravadi RK, Wu H, Yin X, Liu Q, Lu Y, Mills GB, Xu X, George DL, Weeraratna AT, Murphy ME
Cancer Res, 76(9):2720-2730, 16 Mar 2016
Cited by: 24 articles | PMID: 26984758 | PMCID: PMC4939897
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An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model.
Jennis M, Kung CP, Basu S, Budina-Kolomets A, Leu JI, Khaku S, Scott JP, Cai KQ, Campbell MR, Porter DK, Wang X, Bell DA, Li X, Garlick DS, Liu Q, Hollstein M, George DL, Murphy ME
Genes Dev, 30(8):918-930, 31 Mar 2016
Cited by: 233 articles | PMID: 27034505 | PMCID: PMC4840298
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, [...] Zughaier SM
Autophagy, 12(1):1-222, 01 Jan 2016
Cited by: 3223 articles | PMID: 26799652 | PMCID: PMC4835977
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Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate.
Zhang P, Leu JI, Murphy ME, George DL, Marmorstein R
PLoS One, 9(7):e103518, 24 Jul 2014
Cited by: 63 articles | PMID: 25058147 | PMCID: PMC4110032
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Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket.
Leu JI, Zhang P, Murphy ME, Marmorstein R, George DL
ACS Chem Biol, 9(11):2508-2516, 28 Aug 2014
Cited by: 34 articles | PMID: 25148104 | PMCID: PMC4241170
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A modified HSP70 inhibitor shows broad activity as an anticancer agent.
Balaburski GM, Leu JI, Beeharry N, Hayik S, Andrake MD, Zhang G, Herlyn M, Villanueva J, Dunbrack RL, Yen T, George DL, Murphy ME
Mol Cancer Res, 11(3):219-229, 09 Jan 2013
Cited by: 62 articles | PMID: 23303345 | PMCID: PMC3606282
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The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver.
Leu JI, Murphy ME, George DL
J Liver, 2(1):117, 01 Jan 2013
Cited by: 8 articles | PMID: 23991369 | PMCID: PMC3753047
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HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.
Leu JI, Pimkina J, Pandey P, Murphy ME, George DL
Mol Cancer Res, 9(7):936-947, 02 Jun 2011
Cited by: 83 articles | PMID: 21636681 | PMCID: PMC3140602
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1-25 of 39 results

1 2

Search life-sciences literature (45,104,206 articles, preprints and more)

Search results

The Ashkenazi-Centric G334R Variant of <i>TP53</i> is Severely Impaired for Transactivation but Retains Tumor Suppressor Function in a Mouse Model.

Deciphering the impact of genomic variation on function.

An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.

Common activities and predictive gene signature identified for genetic hypomorphs of TP53.

Targeting ErbB3 and Cellular NADPH/NADP⁺ Abundance Sensitizes Cutaneous Melanomas to Ferroptosis Inducers.

HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS-mutant melanoma.

Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser.

P53 regulates cellular redox state, ferroptosis and metabolism.

Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53.

A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors.

Author Correction: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.

Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53.

Tailoring Chemotherapy for the African-Centric S47 Variant of TP53.

Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function.

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction.

HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate.

Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket.

A modified HSP70 inhibitor shows broad activity as an anticancer agent.

The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver.

HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.

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