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Search life-sciences literature (45,103,589 articles, preprints and more)

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A novel loss-of-function <i>KCNB1</i> gene variant in a twin with global developmental delay and seizures.
Manville RW, Illeck CL, Santos C, Sidlow R, Abbott GW
Front Cell Neurosci, 18:1477989, 14 Oct 2024
Cited by: 0 articles | PMID: 39469306 | PMCID: PMC11513283
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Discovery of a potent, Kv7.3-selective potassium channel opener from a Polynesian traditional botanical anticonvulsant.
Abbott GW, Manville RW
Commun Chem, 7(1):233, 10 Oct 2024
Cited by: 0 articles | PMID: 39390220 | PMCID: PMC11467302
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Polymodal K⁺ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines.
Manville RW, Yoshimura RF, Yeromin AV, Hogenkamp D, van der Horst J, Zavala A, Chinedu S, Arena G, Lasky E, Fisher M, Tracy CR, Othy S, Jepps TA, Cahalan MD, Abbott GW
Commun Biol, 7(1):1059, 28 Aug 2024
Cited by: 1 article | PMID: 39198706 | PMCID: PMC11358443
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Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity.
Tian G, Bartas K, Hui M, Chen L, Vasquez JJ, Azouz G, Derdeyn P, Manville RW, Ho EL, Fang AS, Li Y, Tyler I, Setola V, Aoto J, Abbott GW, Beier KT
Neuron, 112(20):3470-3485.e12, 16 Aug 2024
Cited by: 1 article | PMID: 39153478
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A novel autism-associated KCNB1 mutation dramatically slows Kv2.1 potassium channel activation, deactivation and inactivation.
Manville RW, Block SD, Illeck CL, Kottmeier J, Sidlow R, Abbott GW
Front Cell Neurosci, 18:1438101, 29 Jul 2024
Cited by: 1 article | PMID: 39135902 | PMCID: PMC11317242
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Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity
Tian G, Bartas K, Hui M, Chen L, Vasquez JJ, Azouz G, Derdeyn P, Manville RW, Ho EL, Fang AS, Li Y, Tyler I, Setola V, Aoto J, Abbott GW, Beier KT
bioRxiv, 31 May 2024
Cited by: 0 articles | PPR: PPR859953
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Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels.
Manville RW, Baldwin SN, Eriksen EØ, Jepps TA, Abbott GW
FASEB J, 37(9):e23125, 01 Sep 2023
Cited by: 0 articles | PMID: 37535015 | PMCID: PMC10437472
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The plant-derived alkaloid aloperine prevents ischemia/reperfusion injury-induced sudden cardiac death.
Hu Z, Li J, Liu Q, Manville RW, Abbott GW
FASEB J, 37(7):e22999, 01 Jul 2023
Cited by: 2 articles | PMID: 37249366
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Ancient medicinal plant rosemary contains a highly efficacious and isoform-selective KCNQ potassium channel opener.
Manville RW, Hogenkamp D, Abbott GW
Commun Biol, 6(1):644, 15 Jun 2023
Cited by: 5 articles | PMID: 37322081 | PMCID: PMC10272180
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Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain.
Manville RW, Alfredo Freites J, Sidlow R, Tobias DJ, Abbott GW
Nat Commun, 14(1):3281, 06 Jun 2023
Cited by: 5 articles | PMID: 37280215 | PMCID: PMC10244465
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KCNQ5 activation by tannins mediates vasorelaxant effects of barks used in Native American botanical medicine.
Manville RW, Redford KE, van der Horst J, Hogenkamp DJ, Jepps TA, Abbott GW
FASEB J, 36(9):e22457, 01 Sep 2022
Cited by: 5 articles | PMID: 35997997 | PMCID: PMC9404676
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Case report: A novel loss-of-function pathogenic variant in the KCNA1 cytoplasmic N-terminus causing carbamazepine-responsive type 1 episodic ataxia.
Manville RW, Sidlow R, Abbott GW
Front Neurol, 13:975849, 09 Aug 2022
Cited by: 3 articles | PMID: 36016548 | PMCID: PMC9397541
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Divergent effects of HIV reverse transcriptase inhibitors on pancreatic beta-cell function and survival: Potential role of oxidative stress and mitochondrial dysfunction.
Maandi SC, Maandi MT, Patel A, Manville RW, Mabley JG
Life Sci, 294:120329, 26 Jan 2022
Cited by: 5 articles | PMID: 35090905
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KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics.
Abbott GW, Redford KE, Yoshimura RF, Manville RW, Moreira L, Tran K, Arena G, Kookootsedes A, Lasky E, Gunnison E
Front Physiol, 12:777057, 11 Nov 2021
Cited by: 8 articles | PMID: 34858215 | PMCID: PMC8632246
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Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations.
Martin-Batista E, Manville RW, Rivero-Pérez B, Bartolomé-Martín D, Alvarez de la Rosa D, Abbott GW, Giraldez T
Front Mol Neurosci, 14:798261, 26 Nov 2021
Cited by: 0 articles | PMID: 34899186 | PMCID: PMC8662703
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Activation of SGK1.1 up-regulates the M-current in the presence of epilepsy mutations
Martin-Batista E, Manville RW, Rivero-Pérez B, Bartolomé-Martín D, de la Rosa DA, Abbott GW, Giraldez T
bioRxiv, 20 Oct 2021
Cited by: 0 articles | PPR: PPR409009
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The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels.
Manville RW, Abbott GW
Cell Physiol Biochem, 55(s3):157-170, 01 Jul 2021
Cited by: 9 articles | PMID: 34318654 | PMCID: PMC8610427
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Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion.
Lisewski U, Köhncke C, Schleussner L, Purfürst B, Lee SM, De Silva A, Manville RW, Abbott GW, Roepke TK
FASEB J, 34(8):10699-10719, 25 Jun 2020
Cited by: 3 articles | PMID: 32584506 | PMCID: PMC8638375
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Author Correction: Allosteric regulation of mammalian Na⁺/I^- symporter activity by perchlorate.
Llorente-Esteban A, Manville RW, Reyna-Neyra A, Abbott GW, Amzel LM, Carrasco N
Nat Struct Mol Biol, 27(7):683, 01 Jul 2020
Cited by: 0 articles | PMID: 32472109
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Potassium channels act as chemosensors for solute transporters.
Manville RW, Abbott GW
Commun Biol, 3(1):90, 28 Feb 2020
Cited by: 11 articles | PMID: 32111967 | PMCID: PMC7048750
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TOK channels use the two gates in classical K⁺ channels to achieve outward rectification.
Lewis A, McCrossan ZA, Manville RW, Popa MO, Cuello LG, Goldstein SAN
FASEB J, 34(7):8902-8919, 10 Jun 2020
Cited by: 2 articles | PMID: 32519783 | PMCID: PMC7501187
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Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly.
van der Horst J, Manville RW, Hayes K, Thomsen MB, Abbott GW, Jepps TA
Arterioscler Thromb Vasc Biol, 40(5):1207-1219, 19 Mar 2020
Cited by: 9 articles | PMID: 32188278 | PMCID: PMC7180128
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Allosteric regulation of mammalian Na⁺/I^- symporter activity by perchlorate.
Llorente-Esteban A, Manville RW, Reyna-Neyra A, Abbott GW, Amzel LM, Carrasco N
Nat Struct Mol Biol, 27(6):533-539, 25 May 2020
Cited by: 12 articles | PMID: 32451489 | PMCID: PMC10158964
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Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine.
Manville RW, Abbott GW
J Pharmacol Exp Ther, 373(3):391-401, 26 Mar 2020
Cited by: 12 articles | PMID: 32217768 | PMCID: PMC7228494
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In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner.
Manville RW, Abbott GW
Commun Biol, 2:401, 01 Nov 2019
Cited by: 5 articles | PMID: 31701029 | PMCID: PMC6825221
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1-25 of 34 results

1 2

Search life-sciences literature (45,103,589 articles, preprints and more)

Search results

A novel loss-of-function <i>KCNB1</i> gene variant in a twin with global developmental delay and seizures.

Discovery of a potent, Kv7.3-selective potassium channel opener from a Polynesian traditional botanical anticonvulsant.

Polymodal K⁺ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines.

Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity.

A novel autism-associated KCNB1 mutation dramatically slows Kv2.1 potassium channel activation, deactivation and inactivation.

Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity

Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels.

The plant-derived alkaloid aloperine prevents ischemia/reperfusion injury-induced sudden cardiac death.

Ancient medicinal plant rosemary contains a highly efficacious and isoform-selective KCNQ potassium channel opener.

Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain.

KCNQ5 activation by tannins mediates vasorelaxant effects of barks used in Native American botanical medicine.

Case report: A novel loss-of-function pathogenic variant in the KCNA1 cytoplasmic N-terminus causing carbamazepine-responsive type 1 episodic ataxia.

Divergent effects of HIV reverse transcriptase inhibitors on pancreatic beta-cell function and survival: Potential role of oxidative stress and mitochondrial dysfunction.

KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics.

Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations.

Activation of SGK1.1 up-regulates the M-current in the presence of epilepsy mutations

The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels.

Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion.

Author Correction: Allosteric regulation of mammalian Na⁺/I^- symporter activity by perchlorate.

Potassium channels act as chemosensors for solute transporters.

TOK channels use the two gates in classical K⁺ channels to achieve outward rectification.

Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly.

Allosteric regulation of mammalian Na⁺/I^- symporter activity by perchlorate.

Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine.

In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner.

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