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An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania.
Loh L, Saunders PM, Faoro C, Font-Porterias N, Nemat-Gorgani N, Harrison GF, Sadeeq S, Hensen L, Wong SC, Widjaja J, Clemens EB, Zhu S, Kichula KM, Tao S, Zhu F, Montero-Martin G, Fernandez-Vina M, Guethlein LA, Vivian JP, [...] Norman PJ
Cell, S0092-8674(24)01153-X, 29 Oct 2024
Cited by: 0 articles | PMID: 39476840
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Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy.
Subramanian A, Nemat-Gorgani N, Ellis-Caleo TJ, van IJzendoorn DGP, Sears TJ, Somani A, Luca BA, Zhou MY, Bradic M, Torres IA, Oladipo E, New C, Kenney DE, Avedian RS, Steffner RJ, Binkley MS, Mohler DG, Tap WD, D'Angelo SP, [...] Moding EJ
Nat Cancer, 5(4):642-658, 01 Mar 2024
Cited by: 1 article | PMID: 38429415
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Evolutionary pressures shape soft tissue sarcoma development and radiotherapy response
Blomain E, Soudi S, Somani A, Subramanian A, Oladipo E, New C, Kenney D, Nemat-Gorgani N, Avedian R, Steffner R, Mohler D, Hiniker S, Chin A, Kalbasi A, Binkley M, de Rijn Mv, Moding E
Research Square, 26 Sep 2023
Cited by: 0 articles | PPR: PPR731382
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Monitoring Sarcoma Response to Immune Checkpoint Inhibition and Local Cryotherapy with Circulating Tumor DNA Analysis.
Bui NQ, Nemat-Gorgani N, Subramanian A, Torres IA, Lohman M, Sears TJ, van de Rijn M, Charville GW, Becker HC, Wang DS, Hwang GL, Ganjoo KN, Moding EJ
Clin Cancer Res, 29(14):2612-2620, 01 Jul 2023
Cited by: 1 article | PMID: 37130154
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KIR-HLA interactions extend human CD8+ T cell lifespan in vivo.
Zhang Y, Yan AW, Boelen L, Hadcocks L, Salam A, Gispert DP, Spanos L, Bitria LM, Nemat-Gorgani N, Traherne JA, Roberts C, Koftori D, Taylor GP, Forton D, Norman PJ, Marsh SG, Busch R, Macallan DC, Asquith B
J Clin Invest, 133(12):e169496, 15 Jun 2023
Cited by: 5 articles | PMID: 37071474 | PMCID: PMC10266773
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Comparison of NK alloreactivity prediction models based on KIR-MHC interactions in haematopoietic stem cell transplantation.
Dhuyser A, Remen T, Pérès M, Chamberlain-Evans V, Nemat-Gorgani N, Campidelli A, Clément S, Rubio MT, Trowsdale J, Aarnink A, Traherne J
Front Immunol, 14:1028162, 02 Mar 2023
Cited by: 1 article | PMID: 36936953 | PMCID: PMC10017772
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KIR in Allogeneic Hematopoietic Stem Cell Transplantation: Need for a Unified Paradigm for Donor Selection.
Dhuyser A, Aarnink A, Pérès M, Jayaraman J, Nemat-Gorgani N, Rubio MT, Trowsdale J, Traherne J
Front Immunol, 13:821533, 15 Feb 2022
Cited by: 7 articles | PMID: 35242134 | PMCID: PMC8886110
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Following Transplantation for Acute Myelogenous Leukemia, Donor KIR Cen B02 Better Protects against Relapse than KIR Cen B01.
Guethlein LA, Beyzaie N, Nemat-Gorgani N, Wang T, Ramesh V, Marin WM, Hollenbach JA, Schetelig J, Spellman SR, Marsh SGE, Cooley S, Weisdorf DJ, Norman PJ, Miller JS, Parham P
J Immunol, 206(12):3064-3072, 11 Jun 2021
Cited by: 10 articles | PMID: 34117109 | PMCID: PMC8664929
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Adaptive Admixture of HLA Class I Allotypes Enhanced Genetically Determined Strength of Natural Killer Cells in East Asians.
Deng Z, Zhen J, Harrison GF, Zhang G, Chen R, Sun G, Yu Q, Nemat-Gorgani N, Guethlein LA, He L, Tang M, Gao X, Cai S, Palmer WH, Shortt JA, Gignoux CR, Carrington M, Zou H, Parham P, [...] Norman PJ
Mol Biol Evol, 38(6):2582-2596, 01 May 2021
Cited by: 16 articles | PMID: 33616658 | PMCID: PMC8136484
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High-Resolution Characterization of KIR Genes in a Large North American Cohort Reveals Novel Details of Structural and Sequence Diversity.
Amorim LM, Augusto DG, Nemat-Gorgani N, Montero-Martin G, Marin WM, Shams H, Dandekar R, Caillier S, Parham P, Fernández-Viña MA, Oksenberg JR, Norman PJ, Hollenbach JA
Front Immunol, 12:674778, 07 May 2021
Cited by: 17 articles | PMID: 34025673 | PMCID: PMC8137979
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Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease.
Anderson KM, Augusto DG, Dandekar R, Shams H, Zhao C, Yusufali T, Montero-Martín G, Marin WM, Nemat-Gorgani N, Creary LE, Caillier S, Mofrad MRK, Parham P, Fernández-Viña M, Oksenberg JR, Norman PJ, Hollenbach JA
J Immunol, 205(5):1323-1330, 24 Jul 2020
Cited by: 17 articles | PMID: 32709660 | PMCID: PMC7484130
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KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors.
Alicata C, Ashouri E, Nemat-Gorgani N, Guethlein LA, Marin WM, Tao S, Moretta L, Hollenbach JA, Trowsdale J, Traherne JA, Ghaderi A, Parham P, Norman PJ
Front Immunol, 11:556, 02 Apr 2020
Cited by: 12 articles | PMID: 32300348 | PMCID: PMC7142237
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Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians
Deng Z, Zhen J, Harrison GF, Zhang G, Chen R, Sun G, Yu Q, Nemat-Gorgani N, Guethlein LA, He L, Tang M, Gao X, Cai S, Shortt JA, Gignoux CR, Carrington M, Zou H, Parham P, Hong W, Norman PJ
bioRxiv, 30 Jul 2020
Cited by: 0 articles | PPR: PPR193870
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In vitro education of human natural killer cells by KIR3DL1.
Pugh J, Pugh J, Nemat-Gorgani N, Djaoud Z, Guethlein LA, Norman PJ, Parham P
Life Sci Alliance, 2(6):e201900434, 13 Nov 2019
Cited by: 6 articles | PMID: 31723004 | PMCID: PMC6856763
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A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson's disease.
Hollenbach JA, Norman PJ, Creary LE, Damotte V, Montero-Martin G, Caillier S, Anderson KM, Misra MK, Nemat-Gorgani N, Osoegawa K, Santaniello A, Renschen A, Marin WM, Dandekar R, Parham P, Tanner CM, Hauser SL, Fernandez-Viña M, Oksenberg JR
Proc Natl Acad Sci U S A, 116(15):7419-7424, 25 Mar 2019
Cited by: 42 articles | PMID: 30910980 | PMCID: PMC6462083
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Conservation, Extensive Heterozygosity, and Convergence of Signaling Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates.
Leaton LA, Shortt J, Kichula KM, Tao S, Nemat-Gorgani N, Mentzer AJ, Oppenheimer SJ, Deng Z, Hollenbach JA, Gignoux CR, Guethlein LA, Parham P, Carrington M, Norman PJ
Front Immunol, 10:24, 28 Jan 2019
Cited by: 18 articles | PMID: 30745901 | PMCID: PMC6360152
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Diversity of KIR, HLA Class I, and Their Interactions in Seven Populations of Sub-Saharan Africans.
Nemat-Gorgani N, Guethlein LA, Henn BM, Norberg SJ, Chiaroni J, Sikora M, Quintana-Murci L, Mountain JL, Norman PJ, Parham P
J Immunol, 202(9):2636-2647, 27 Mar 2019
Cited by: 15 articles | PMID: 30918042 | PMCID: PMC6690726
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Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop.
Misra MK, Augusto DG, Martin GM, Nemat-Gorgani N, Sauter J, Hofmann JA, Traherne JA, González-Quezada B, Gorodezky C, Bultitude WP, Marin W, Vierra-Green C, Anderson KM, Balas A, Caro-Oleas JL, Cisneros E, Colucci F, Dandekar R, Elfishawi SM, [...] Hollenbach JA
Hum Immunol, 79(12):825-833, 12 Oct 2018
Cited by: 14 articles | PMID: 30321631 | PMCID: PMC6322681
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Different Selected Mechanisms Attenuated the Inhibitory Interaction of KIR2DL1 with C2⁺ HLA-C in Two Indigenous Human Populations in Southern Africa.
Nemat-Gorgani N, Hilton HG, Henn BM, Lin M, Gignoux CR, Myrick JW, Werely CJ, Granka JM, Möller M, Hoal EG, Yawata M, Yawata N, Boelen L, Asquith B, Parham P, Norman PJ
J Immunol, 200(8):2640-2655, 16 Mar 2018
Cited by: 21 articles | PMID: 29549179 | PMCID: PMC5990024
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KIR2DS5 allotypes that recognize the C2 epitope of HLA-C are common among Africans and absent from Europeans.
Blokhuis JH, Hilton HG, Guethlein LA, Norman PJ, Nemat-Gorgani N, Nakimuli A, Chazara O, Moffett A, Parham P
Immun Inflamm Dis, 5(4):461-468, 06 Jul 2017
Cited by: 34 articles | PMID: 28685972 | PMCID: PMC5691316
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Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage.
Pugh JL, Nemat-Gorgani N, Norman PJ, Guethlein LA, Parham P
J Immunol, 200(3):1146-1158, 20 Dec 2017
Cited by: 10 articles | PMID: 29263215 | PMCID: PMC5780205
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Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells.
Djaoud Z, Guethlein LA, Horowitz A, Azzi T, Nemat-Gorgani N, Olive D, Nadal D, Norman PJ, Münz C, Parham P
J Exp Med, 214(6):1827-1841, 03 May 2017
Cited by: 41 articles | PMID: 28468758 | PMCID: PMC5460997
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HLA class I variation in Iranian Lur and Kurd populations: high haplotype and allotype diversity with an abundance of KIR ligands.
Ashouri E, Norman PJ, Guethlein LA, Han AS, Nemat-Gorgani N, Norberg SJ, Ghaderi A, Parham P
HLA, 88(3):87-99, 24 Aug 2016
Cited by: 7 articles | PMID: 27558013 | PMCID: PMC5063635
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Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.
Norman PJ, Norberg SJ, Guethlein LA, Nemat-Gorgani N, Royce T, Wroblewski EE, Dunn T, Mann T, Alicata C, Hollenbach JA, Chang W, Shults Won M, Gunderson KL, Abi-Rached L, Ronaghi M, Parham P
Genome Res, 27(5):813-823, 30 Mar 2017
Cited by: 54 articles | PMID: 28360230 | PMCID: PMC5411776
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Class I HLA haplotypes form two schools that educate NK cells in different ways.
Horowitz A, Djaoud Z, Nemat-Gorgani N, Blokhuis J, Hilton HG, Béziat V, Malmberg KJ, Norman PJ, Guethlein LA, Parham P
Sci Immunol, 1(3):eaag1672, 09 Sep 2016
Cited by: 115 articles | PMID: 27868107 | PMCID: PMC5110269
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1-25 of 38 results

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Search life-sciences literature (45,100,050 articles, preprints and more)

Search results

An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania.

Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy.

Evolutionary pressures shape soft tissue sarcoma development and radiotherapy response

Monitoring Sarcoma Response to Immune Checkpoint Inhibition and Local Cryotherapy with Circulating Tumor DNA Analysis.

KIR-HLA interactions extend human CD8+ T cell lifespan in vivo.

Comparison of NK alloreactivity prediction models based on KIR-MHC interactions in haematopoietic stem cell transplantation.

KIR in Allogeneic Hematopoietic Stem Cell Transplantation: Need for a Unified Paradigm for Donor Selection.

Following Transplantation for Acute Myelogenous Leukemia, Donor KIR Cen B02 Better Protects against Relapse than KIR Cen B01.

Adaptive Admixture of HLA Class I Allotypes Enhanced Genetically Determined Strength of Natural Killer Cells in East Asians.

High-Resolution Characterization of KIR Genes in a Large North American Cohort Reveals Novel Details of Structural and Sequence Diversity.

Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease.

KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors.

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

In vitro education of human natural killer cells by KIR3DL1.

A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson's disease.

Conservation, Extensive Heterozygosity, and Convergence of Signaling Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates.

Diversity of KIR, HLA Class I, and Their Interactions in Seven Populations of Sub-Saharan Africans.

Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop.

Different Selected Mechanisms Attenuated the Inhibitory Interaction of KIR2DL1 with C2⁺ HLA-C in Two Indigenous Human Populations in Southern Africa.

KIR2DS5 allotypes that recognize the C2 epitope of HLA-C are common among Africans and absent from Europeans.

Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage.

Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells.

HLA class I variation in Iranian Lur and Kurd populations: high haplotype and allotype diversity with an abundance of KIR ligands.

Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.

Class I HLA haplotypes form two schools that educate NK cells in different ways.

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